Results 81 to 90 of about 3,808,718 (357)

Anthropogenic nitrogen autotrophy and heterotrophy of the world's watersheds: Past, present, and future trends [PDF]

open access: yes, 2010
Anthropogenic nitrogen autotrophy of a territory is defined as the nitrogen flux associated with local production of harvested crops and grass consumed by livestock grazing (in kg N/km(2)/yr).
Beusen, A.   +3 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Nitrogen fixing shade trees in coffee agroforestry: Quantification of nitrogen transfer to the coffee plant [PDF]

open access: yes, 2019
Nitrogen-fixing shade trees in coffee agroforestry systems are assumed to provide an alternative nitrogen source for the coffee crop when fertilizer applications are low, but the transfer of nitrogen from shade trees to the coffee crop has not yet been ...
Blanchart, Eric   +3 more
core  

Agroecosystems, Nitrogen-use Efficiency, and Nitrogen Management

open access: yesAMBIO: A Journal of the Human Environment, 2002
The global challenge of meeting increased food demand and protecting environmental quality will be won or lost in cropping systems that produce maize, rice, and wheat. Achieving synchrony between N supply and crop demand without excess or deficiency is the key to optimizing trade-offs amongst yield, profit, and environmental protection in both large ...
Cassman, Kenneth G   +2 more
openaire   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

NPBS Atlas: a comprehensive data resource for exploring the biological sources of natural products

open access: yesJournal of Cheminformatics
Natural products continue to play a pioneering role in drug discovery due to their extraordinary chemical and biological diversity. However, their full therapeutic potential remains largely underutilized, hindered by the fragmented documentation of ...
Tingjun Xu   +6 more
doaj   +1 more source

Effects of Nitrogen Fertilization on Monoterpenes of Jack Pine Seedlings and Weight Gain of Jack Pine Budworm (Lepidoptera: Tortricidae) [PDF]

open access: yes, 2017
Nine-month old jack pine (Pinus banksiana) seedlings were grown in a greenhouse under four nitrogen fertilization regimes. Levels of total nitrogen and five monoterpenes in new foliage were measured. Fertilization resulted in four significantly different
Kulman, Herbert M   +2 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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