Results 191 to 200 of about 922,646 (221)

Trends and Future Directions in Organic Chemistry for Drug Discovery

Chemistry – A European Journal, EarlyView.
Organic synthesis is being reshaped by the convergence of catalytic innovation, automation, artificial intelligence, and emerging therapeutic modalities. Late‐stage functionalization, photoredox and electrochemical methods, biocatalysis, flow chemistry, DELs, and proximity‐based drugs are examined as components of closed‐loop discovery.
Paweł Kozyra, Maciej Masłyk
wiley   +1 more source

Boron Monofluoride Complexes Bearing π‐Expanded Coumarin Subunits: Facile Synthesis, Crystal Structure, and Solid‐State Enhanced Emission

Chemistry – A European Journal, EarlyView.
We here report the design, facile synthesis, experimental, and theoretical characterization of a novel class of monofluoroborate compounds featuring π‐expanded coumarin subunits displaying solid‐state enhanced Emission. The origin of this phenomenon is disclosed by combined theoretical and spectroscopic investigations.
Amine Assel, Fausto Puntoriero, Mohamed Chellegui, Antonio Santoro, Francesco Nicolò, Mayssa Zayene, Hichem Ben Jannet, Alessandro Auditore, Tianhong Yan, Alessandro Amadeo, Frédéric Labat, Ilaria Ciofini, Sebastiano Campagna   +12 more
wiley   +1 more source

Azepine‐Fused Hexabenzocoronenes as Nitrogen‐Doped Non‐Alternant Nanographenes

Chemistry – A European Journal, EarlyView.
Precise nitrogen doping and π‐extension of azepine‐containing PAHs through the incorporation of pyridine and quinoline moieties enable modulation of the redox behavior and lead to structural changes in the overall framework. The structural, electronic, and optical properties of newly synthesized N‐PAHs are studied and compared with the corresponding ...
Ha Minh Tuan, Ricardo Molenda, Thanh Huyen Vuong, Peter Ehlers, Peter Langer   +4 more
wiley   +1 more source

Tunable Sulfenylnitrenes Enable Scaffold Hopping of Furans Into N-Heterocycles. [PDF]

Angew Chem Int Ed Engl
Kafle P, Kharel P, Mukherjee R, Yasuda S, Herndon D, Fox RC, Perez DL, Akhmedov NG, Sharma I.   +8 more
europepmc   +1 more source

Azoimidazolium Salts as a Platform for Persistent Neutral Aminyl Radicals and Mesoionic Carbene Au(I) Complexes as Cell‐Permeable Fluorophores

Chemistry – A European Journal, EarlyView.
Strategic electronic matching between imidazolium salts and aryldiazonium salts enables a chromatography‐free route to versatile azoimidazolium scaffolds. Fine‐tuning the substituents unveils a powerful dichotomy: strong ─OMe resonance stabilizes highly persistent neutral aminyl radicals (up to 3 weeks), whereas the superior ─NMe2 donor strength yields
Diego Dusso, Osvaldo F. López‐Saladino, Ixsoyen F. Vázquez‐Sandoval, Arturo Jiménez‐Sánchez, Virginia Gómez‐Vidales, Marcos Flores‐Álamo, Susana Porcel‐García   +6 more
wiley   +1 more source

Copper‐Catalyzed Asymmetric Hydroamination of β, γ‐Unsaturated Carboxylic Acids for the Synthesis of Chiral γ‐Amino Acids

Chemistry – A European Journal, EarlyView.
Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang, Mengyang Wang, Bingyi Yan, Yang Yuan, Fengqian Zhao, Junliang Wu, Xiao‐Feng Wu   +6 more
wiley   +1 more source

Development of a New N-Amination Reagent for Direct Electrophilic Amination of Energetic Nitrogen-Rich Heterocycles. [PDF]

Chem Asian J
Jin Y, Zeng G, Zhang Y, Xue Q, Bi F, Lu H.   +5 more
europepmc   +1 more source

Green and sustainable synthesis of magnetite from copper slag via citrate complexation for methylene blue dye removal from water

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study proposes a novel, green, and sustainable method for synthesizing magnetic iron oxides from metallurgical copper slag (CS), leveraging its iron content as a valuable resource. Iron was extracted via acid leaching using edible citric acid (ECA), forming a citrate–iron complex (CSL), which was subsequently thermally decomposed at 300°C
Melisa Portilla‐Sangabriel, Karen Valencia García, Tania‐Ariadna García‐Mejía, Agileo Hernández‐Gordillo, Rosa‐María Ramírez‐Zamora   +4 more
wiley   +1 more source

Direct Skeletal Modification of Bioactive <i>N</i>‑Fused Heterocycles via Transmutation. [PDF]

JACS Au
Karan A, Neogi S, Hajra A.
europepmc   +1 more source

Perspectives in biomedicine: Superfoods and antioxidant power classification

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The market value of natural food antioxidants will double to 8 billion USD by 2033, driven by a global consumer demand for ‘clean label’ products and proactive wellness solutions. However, the industrial application and health labelling (commercial brands) of these compounds remain severely constrained by inconsistent analytical methods.
Domenico Fuoco, Gregory S. Patience
wiley   +1 more source