Results 181 to 190 of about 1,403,091 (264)
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N-Atom Deletion in Nitrogen Heterocycles.
Angewandte Chemie, 2021Excising the nitrogen in secondary amines, and coupling the two residual fragments is a skeletal editing strategy that can be used to construct molecules with new skeletons, but which has been largely unexplored.
Haitao Qin +5 more
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Organic Letters, 2021
A method for regioselective ring openings of 3,4- and 2,3-epoxy alcohols with ambident nitrogen heterocycles is described. Using a diarylborinic acid catalyst, a single regioisomer is favored in couplings of nucleophile and electrophile partners that ...
Shrey Desai, M. Taylor
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A method for regioselective ring openings of 3,4- and 2,3-epoxy alcohols with ambident nitrogen heterocycles is described. Using a diarylborinic acid catalyst, a single regioisomer is favored in couplings of nucleophile and electrophile partners that ...
Shrey Desai, M. Taylor
semanticscholar +1 more source
Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles
Synthesis, 2020A convenient oxidative cyclodesulfurization method toward the synthesis of benzofused nitrogen heterocycles using inexpensive and readily available potassium periodate as an oxidant was developed.
Chuthamat Duangkamol +2 more
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Isocyanides in the Synthesis of Nitrogen Heterocycles
Angewandte Chemie International Edition, 2010AbstractIsocyanides have long proved themselves to be irreplaceable building blocks in modern organic chemistry. The unique features of the isocyano group make isocyanides particularly useful for the synthesis of a number of important classes of nitrogen heterocycles, such as pyrroles, indoles, and quinolines.
Alexander V, Lygin, Armin, de Meijere
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2021
Much of central nitrogen biology occurs via the biosynthesis and chemical functionality of nitrogen heterocycles. This is the first of three consecutive chapters that examine common forms of nitrogen heterocyclic metabolites and the biological roles enabled.
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Much of central nitrogen biology occurs via the biosynthesis and chemical functionality of nitrogen heterocycles. This is the first of three consecutive chapters that examine common forms of nitrogen heterocyclic metabolites and the biological roles enabled.
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Current organic chemistry, 2022
The fused Nitrogen heterocyclic compounds and their derivatives have grown in prominence over the past several decades as a result of their significant medical value.
T. Lambat +8 more
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The fused Nitrogen heterocyclic compounds and their derivatives have grown in prominence over the past several decades as a result of their significant medical value.
T. Lambat +8 more
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Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N-heterocycles.
ScienceGiven the prevalence of nitrogen-containing heterocycles in commercial drugs, selectively incorporating a single nitrogen atom is a promising scaffold hopping approach to enhance chemical diversity in drug discovery libraries.
Bidhan Ghosh +7 more
semanticscholar +1 more source
Construction of Oxygen‐ and Nitrogen‐based Heterocycles from p‐Quinone Methides
The chemical record, 2021In the last few years, there has been an explosive growth in the area of para‐quinone methide (p‐QM) chemistry. This boom is actually due to the unique reactivity pattern of p‐QMs, and also their remarkable synthetic applications. In fact, p‐QMs serve as
Gurdeep Singh +4 more
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Application and challenges of nitrogen heterocycles in PROTAC linker.
European journal of medicinal chemistryThe absence of effective active pockets makes traditional molecularly targeted drug strategies ineffective against 80 % of human disease-related proteins.
Yang Li +7 more
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