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Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents [PDF]
Molecules, 2022 Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence
Tuyen N. Tran, Maged Henary
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Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective [PDF]
Pharmaceuticals, 2023 Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance.
Adarsh Kumar +14 more
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N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles [PDF]
Beilstein Journal of Organic Chemistry, 2021 The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other compounds presenting different types of biological activities have proved to be successful employing chiral sulfinyl imines derived from tert-butanesulfinamide ...
Joseane A. Mendes +4 more
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Recent advances in metal catalyst- and oxidant-free electrochemical C-H bond functionalization of nitrogen-containing heterocycles [PDF]
Frontiers in Chemistry, 2022 The C-H functionalization of nitrogen-containing heterocycles has emerged as a powerful strategy for the construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds.
Ya-Nan Li +4 more
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Recent advances in synthesizing and utilizing nitrogen-containing heterocycles [PDF]
Frontiers in Chemistry, 2023 The use of organocatalysts and a pot economy has strengthened recent organic syntheses. Synthetic methodologies may be applicable in laboratory preparation or in the industrial production of valuable organic compounds. In most cases, synthetic challenges
Hyun-Joon Ha
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Molecules, 2023 Nitrogen-containing heterocycles are ubiquitous in natural products and drugs. Various organic small molecules with nitrogen-containing heterocycles, such as nitrogen-containing boron compounds, cyanine, pyridine derivatives, indole derivatives ...
Yanan Li, Tao Liu, Jianan Sun
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Pharmaceutics, 2023 Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial drug.
Aura Rusu +3 more
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Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023 Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic.
Rogov, Danila A. +1 more
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A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications
Molecules, 2020 The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing ...
Nagaraju Kerru +4 more
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Insertion of ammonia into alkenes to build aromatic N-heterocycles
Nature Communications, 2022 Aromatic heterocycles containing nitrogen are ubiquitous in biologically relevant small molecules. Here the authors show an unorthodox methodology for their synthesis, by inserting the nitrogen atom into a carbon ring, with ammonia in electrochemical ...
Shuai Liu, Xu Cheng
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