Results 21 to 30 of about 2,873,864 (246)
Insertion of ammonia into alkenes to build aromatic N-heterocycles
Nature Communications, 2022 Aromatic heterocycles containing nitrogen are ubiquitous in biologically relevant small molecules. Here the authors show an unorthodox methodology for their synthesis, by inserting the nitrogen atom into a carbon ring, with ammonia in electrochemical ...
Shuai Liu, Xu Cheng
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Synthesis of unprotected nitrogen-containing heterocycles via Aza Heck reactions
, 2022 Watson, Donald A.The main objective of this thesis is centered around the identification of novel amide electrophiles for the development of aza-Heck-type reactions.
Shuler, Scott Adam
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Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry. [PDF]
RSC Adv, 2020 Nitrogen containing heterocycles are of immense research interest because they are often found as naturally occurring bioactive compounds. The prominence of N-heterocycles makes it vital to develop methods to increase their synthetic efficiencies and ...
Henary M +5 more
europepmc +2 more sources
Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles. [PDF]
Adv Sci (Weinh)We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Zhu Y +9 more
europepmc +2 more sources
Synthesis of six membered heterocycles containing nitrogen or oxygen [PDF]
, 2017 Six-membered heterocycles containing nitrogen and oxygen are prevalent in natural products and pharmaceutical drugs; hence efficient synthesis of these motifs is of great benefit.
Turner, Peter G.
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Synthesis and Reactivity of 3H-1,2-dithiole-3-thiones
Molecules, 2021 3H-1,2-Dithiole-3-thiones are among the best studied classes of polysulfur-containing heterocycles due to the almost explosive recent interest in these compounds as sources of hydrogen sulfide as an endogenously produced gaseous signaling molecule.
Oleg A. Rakitin
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Nature Communications, 2022 Methods to assemble axially chiral biaryl molecules with nitrogen-containing heterocycles can have implications in ligand development for homogeneous catalysis. Here the authors report enantioselective syntheses of axially chiral arylquinolizones, via an
Xiao-Long Min +3 more
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Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles
Molecules, 2022 Betulinic acid (BA) was used as starting building block to create a library of novel BA-derived compounds containing O- and N-heterocycles. Firstly, BA was converted into methyl betulonate (BoOMe), which was used as intermediate in the developed ...
Joana L. C. Sousa +3 more
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Proceedings, 2019 Nitrogen-containing heterocycles such as quinazolines and benzofurans have received a great amount of interest in targeted therapies as antitumor drugs [1]. [...]
Marole Maria Maluleka +1 more
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, 2008 Cu2O was found to be a simple and efficient catalyst for the N-arylation of a variety of nitrogen-containing heterocycles with aryl and heteroaryl chlorides, bromides and iodides to give the products in excellent yields.
Huang, Yi-Zheng +5 more
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