Results 1 to 10 of about 117,443 (105)
Frontiers in Molecular Biosciences, 2023 Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.Objective: 2D- and 3D-QSAR (structure ...
Wenkun Zhuo +4 more
doaj +4 more sources
Synthesis of nitrogen mustard-based fluorophores for cell imaging and cytotoxicity studies
Journal of Advanced Pharmaceutical Technology & Research, 2023 Nitrogen mustards are important alkylating anticancer drugs used for neoplasms treatment. However, little research about the integration of luminophore into nitrogen mustard-based compounds for both imaging and therapeutic application was reported.
Yuanwei Liang +5 more
doaj +2 more sources
Degradation of Chemical Warfare Agent Nitrogen Mustard Using Ferrate (VI)
Toxics, 2023 Chemical warfare agents (CWAs) are one of the most toxic compounds. Degradation of CWAs using decontamination agents is one of the few ways to protect human health against the harmful effects of CWAs. A ferrate (VI)-based potential chemical warfare agent
Miroslav Labaška +2 more
doaj +2 more sources
Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules
Frontiers in Pharmacology, 2018 As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of ...
Yiming Chen +3 more
doaj +2 more sources
Clinical studies on triethylenephosphoramide and diethylenephosphoramide, compounds with nitrogen-mustard-like activity [PDF]
Cancer, 1953 RIETHYLENEMELAMINE (2,4,6-triethylenimi-T no-s ...
David A. Karnofsky +3 more
openaire +3 more sources
MoleculesThe course and kinetics of the reactions of sulfur mustard, nitrogen mustard and their selected analogues with sodium ethoxide were studied using a gas chromatograph coupled with a mass spectrometer.
Klaudia Kozon +3 more
doaj +2 more sources
Acta Radiologica, 1958 Investigations into the protective action of cyeteamine against nitrogen mustard (HN2) are described. A selective protection upon the bone marrow as compared with the small intestine and spleen was observed. The comparative protective action of related agents is discussed in detail and an explanation is put forward for the variation in the toxicity of ...
Aage Juhl Therkelsen
openaire +4 more sources
Agronomy, 2022 Utilizing innovative agricultural practices that enhance the nutritional quality of staple foods such as potatoes provides farmers with tools to successfully meet the challenges of feeding a rising global population while sustaining organic food ...
Daniel Temmen, John Randall, Inna Popova
doaj +1 more source
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
Pharmaceuticals, 2022 Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug ...
Ankit Kumar Singh +13 more
doaj +1 more source
Discovery of a potent olaparib–chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer
Frontiers in Pharmacology, 2023 Introduction: Development of Poly (ADP-ribose) polymerase (PARP) inhibitors has been extensively studied in cancer treatment. Olaparib, the first approved PARP inhibitor, showed potency in the inhibition of both BRCA (breast cancer associated)-mutated ...
Hongyu Qin +5 more
doaj +1 more source