Results 1 to 10 of about 10,547 (176)

3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma [PDF]

Frontiers in Molecular Biosciences, 2023
Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.Objective: 2D- and 3D-QSAR (structure ...
Wenkun Zhuo, Zheng Lian, Wenzhe Bai, Yanrong Chen, Huanling Xia   +4 more
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Amino alkyl-alkyl/aryl sulphides (DRDE-07 and analogues) as promising cytoprotectants for sulphur and nitrogen mustards – A review [PDF]

Toxicology Reports
Several antidotes and medical countermeasures were experimented for the protection of one of the notorious chemical warfare agents, the mustard gas, also known as sulphur mustard (SM).
R. Vijayaraghavan, M. Sharma
doaj   +2 more sources

In Situ Evaluation of the GSH Depletion Ability of Various Alkylating Agents and the Protective Effect of Several Active Thiol Compounds Based on High-Content Cell Analysis [PDF]

Toxics
The depletion degree of reduced glutathione is a critical indicator for assessing the toxicity of alkylating agents. In the present research, we have developed a novel method to evaluate the glutathione (GSH) depletion induced by a series of alkylating ...
Jing Guo, Zhi Li, Jiao Wang, Bo Ma, Liang Zhang, Hairui Wang, Jianfeng Wu, Jianwei Xie   +7 more
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Study on the Reaction Kinetics of Sulfur Mustard, Nitrogen Mustard and Their Chosen Analogues with Sodium Ethoxide [PDF]

Molecules
The course and kinetics of the reactions of sulfur mustard, nitrogen mustard and their selected analogues with sodium ethoxide were studied using a gas chromatograph coupled with a mass spectrometer.
Klaudia Kozon, Jakub Nawała, Paweł Sura, Stanisław Popiel   +3 more
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Synthesis, Clastogenic and Cytotoxic Potential, and In Vivo Antitumor Activity of a Novel N-Mustard Based on Indole-3-carboxylic Acid Derivative [PDF]

Molecules
Compound T1089—a novel nitrogen mustard based on an indole-3-carboxylic acid derivative (ICAD)—has been synthesized. The ICAD used as the basis for T1089 is a TLR agonist capable of activating an antitumor immune response.
Marina Filimonova, Olga Soldatova, Anna Shitova, Valentina Surinova, Vitaly Rybachuk, Alexander Kosachenko, Kirill Nikolaev, Daria Filatova, Ekaterina Prosovskaya, Sergey Ivanov, Petr Shegay, Andrey Kaprin, Alexander Filimonov   +12 more
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Synthesis of nitrogen mustard-based fluorophores for cell imaging and cytotoxicity studies

Journal of Advanced Pharmaceutical Technology & Research, 2023
Nitrogen mustards are important alkylating anticancer drugs used for neoplasms treatment. However, little research about the integration of luminophore into nitrogen mustard-based compounds for both imaging and therapeutic application was reported.
Yuanwei Liang, Maojun Liang, Cuiyu Li, Daini Wang, Xiaoxuan Gong, Kaiji Zheng   +5 more
doaj   +1 more source

Degradation of Chemical Warfare Agent Nitrogen Mustard Using Ferrate (VI)

Toxics, 2023
Chemical warfare agents (CWAs) are one of the most toxic compounds. Degradation of CWAs using decontamination agents is one of the few ways to protect human health against the harmful effects of CWAs. A ferrate (VI)-based potential chemical warfare agent
Miroslav Labaška, Miroslav Gál, Tomáš Mackuľak   +2 more
doaj   +1 more source

The Effect of Sinapis alba Mustard Seed Meal Extract on Potato Tuber Quality in Organic Potato Production

Agronomy, 2022
Utilizing innovative agricultural practices that enhance the nutritional quality of staple foods such as potatoes provides farmers with tools to successfully meet the challenges of feeding a rising global population while sustaining organic food ...
Daniel Temmen, John Randall, Inna Popova
doaj   +1 more source

Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids

Pharmaceuticals, 2022
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug ...
Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Pankaj Sonawane, Harshali Paliwal, Suresh Thareja, Prateek Pathak, Maria Grishina, Mariusz Jaremko, Abdul-Hamid Emwas, Jagat Pal Yadav, Amita Verma, Habibullah Khalilullah, Pradeep Kumar   +13 more
doaj   +1 more source

Discovery of a potent olaparib–chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer

Frontiers in Pharmacology, 2023
Introduction: Development of Poly (ADP-ribose) polymerase (PARP) inhibitors has been extensively studied in cancer treatment. Olaparib, the first approved PARP inhibitor, showed potency in the inhibition of both BRCA (breast cancer associated)-mutated ...
Hongyu Qin, Jian Zhang, Yilu Zhao, Lihui Zhang, Jinhong Feng, Lei Zhang   +5 more
doaj   +1 more source