Results 21 to 30 of about 2,356,861 (215)

Table1_3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma.DOCX

, 2023
Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.Objective: 2D- and 3D-QSAR (structure ...
Wenkun Zhuo (14853163), Wenzhe Bai (14853166), Yanrong Chen (2611009), Huanling Xia (14853169), Zheng Lian (1410199)   +4 more
core   +1 more source

DataSheet1_3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma.ZIP

, 2023
Background: The dipeptide-alkylated nitrogen-mustard compound is a new kind of nitrogen-mustard derivative with a strong anti-tumor activity, which can be used as a potential anti-osteosarcoma chemotherapy drug.Objective: 2D- and 3D-QSAR (structure ...
Wenkun Zhuo (14853163), Wenzhe Bai (14853166), Yanrong Chen (2611009), Huanling Xia (14853169), Zheng Lian (1410199)   +4 more
core   +1 more source

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +2 more sources

ESTUDOS BIOFÍSICOS ENTRE BENDAMUSTINA, UM AGENTE ANTITUMORAL ALQUILANTE, E O DNA: CONTRIBUIÇÕES PARA O ENTENDIMENTO DO PROCESSO DE INTERAÇÃO [PDF]

Química Nova
Understanding the interactions between small ligands and (bio)macromolecules is essential for the development of bioactive compounds. This study investigated the interaction between CT-DNA (calf thymus-deoxyribonucleic acid) and bendamustine (BE), a ...
Victorya G. Silva Medeiros, Carla de A. Vital, Ari S. Guimarães, Isis M. Figueiredo, Josué Carinhanha C. Santos   +4 more
doaj   +1 more source

Glutathione S-conjugates as prodrugs to target drug-resistant tumors

Frontiers in Pharmacology, 2014
Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic detoxification in many species is the conjugation of activated xenobiotics to reduced glutathione (GSH) catalyzed by the glutathione-S-transferase (GST).
Emma E. Ramsay, Pierre J. Dilda
doaj   +1 more source

Isolation and Identification of Gas-Producing Spoilage Bacteria in Wasabi Sauce and Effective Methods for Controlling Their Growth. [PDF]

Food Sci Nutr
Food package bulging, a prevalent spoilage issue in dairy products, beverages, and condiments, is predominantly attributed to gas‐producing spoilage bacteria. These contaminants originate from multiple pathways: raw material contamination, processing cross‐contamination, packaging material leaching, airborne microbial ingress, and inadequate control of
Liu X, Li H, Xu QG, Wu W, Han QD, Liu YG.   +5 more
europepmc   +2 more sources

Macrocyclic nitrogen mustard prodrugs as hypoxia selective anti-cancer agents [PDF]

, 2003
The low selectivity of chemotherapy is an ongoing problem in the treatment of cancer. Prodrugs that are activated in vivo provide a therapeutic advantage for selective cytotoxicity.
Parker, Laura Louise
core   +6 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Shifts in Soil Bacterial Communities as a Function of Carbon Source Used During Anaerobic Soil Disinfestation

Frontiers in Environmental Science, 2019
Anaerobic soil disinfestation (ASD) is an organic amendment-based management practice for controlling soil-borne plant pathogens. Pathogen suppression appears to be carbon source-dependent and mediated by bacteria that proliferate and produce volatile ...
Amisha T. Poret-Peterson, Sebastian Albu, Ali E. McClean, Daniel A. Kluepfel   +3 more
doaj   +1 more source

Dynamics of biotic resistance to plant invasions

Biological Reviews, EarlyView.
ABSTRACT Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long‐term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of ...
Christine S. Sheppard, Joshua I. Brian, Wayne Dawson, Petr Dostál, Franz Essl, Michal Gruntman, Tina Heger, Mark van Kleunen, Mialy Razanajatovo, Lena C. Reimann, Frank M. Schurr, Montserrat Vilà, Florencia A. Yannelli, Marina Golivets   +13 more
wiley   +1 more source