Results 21 to 30 of about 10,807 (177)

ESTUDOS BIOFÍSICOS ENTRE BENDAMUSTINA, UM AGENTE ANTITUMORAL ALQUILANTE, E O DNA: CONTRIBUIÇÕES PARA O ENTENDIMENTO DO PROCESSO DE INTERAÇÃO [PDF]

Química Nova
Understanding the interactions between small ligands and (bio)macromolecules is essential for the development of bioactive compounds. This study investigated the interaction between CT-DNA (calf thymus-deoxyribonucleic acid) and bendamustine (BE), a ...
Victorya G. Silva Medeiros, Carla de A. Vital, Ari S. Guimarães, Isis M. Figueiredo, Josué Carinhanha C. Santos   +4 more
doaj   +1 more source

Glutathione S-conjugates as prodrugs to target drug-resistant tumors

Frontiers in Pharmacology, 2014
Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic detoxification in many species is the conjugation of activated xenobiotics to reduced glutathione (GSH) catalyzed by the glutathione-S-transferase (GST).
Emma E. Ramsay, Pierre J. Dilda
doaj   +1 more source

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

Shifts in Soil Bacterial Communities as a Function of Carbon Source Used During Anaerobic Soil Disinfestation

Frontiers in Environmental Science, 2019
Anaerobic soil disinfestation (ASD) is an organic amendment-based management practice for controlling soil-borne plant pathogens. Pathogen suppression appears to be carbon source-dependent and mediated by bacteria that proliferate and produce volatile ...
Amisha T. Poret-Peterson, Sebastian Albu, Ali E. McClean, Daniel A. Kluepfel   +3 more
doaj   +1 more source

Stabilization of PUFA‐Rich Mayonnaise Against Lipid Oxidation: A Review of the Last Three Decades of Research

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Mayonnaise, a widely consumed oil‐in‐water emulsion, is highly susceptible to lipid oxidation due to its high content of polyunsaturated fatty acids (PUFAs) and the presence of pro‐oxidant factors such as low pH and iron from egg yolk. Over the past three decades, extensive research has focused on understanding oxidation mechanisms, analytical
Sakhi Ghelichi, Betül Yesiltas, Charlotte Jacobsen   +2 more
wiley   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Dynamics of biotic resistance to plant invasions

Biological Reviews, EarlyView.
ABSTRACT Biotic resistance, the reduction in invasion success caused by native communities, plays an important role in the long‐term dynamics of biological invasions. A large body of empirical research on biotic resistance has accumulated since the last comprehensive review on the subject 20 years ago, enabling us to achieve a refined understanding of ...
Christine S. Sheppard, Joshua I. Brian, Wayne Dawson, Petr Dostál, Franz Essl, Michal Gruntman, Tina Heger, Mark van Kleunen, Mialy Razanajatovo, Lena C. Reimann, Frank M. Schurr, Montserrat Vilà, Florencia A. Yannelli, Marina Golivets   +13 more
wiley   +1 more source

Strategies for Identification and Mitigation of Sanguinarine in Mustard Oil Adulterated by Argemone—A Comprehensive Review

Food Chemistry International, EarlyView.
Sanguinarine, a toxic alkaloid present in argemone, can lead to epidemic dropsy or chronic diseases through DNA intercalation and immune system suppression. Regulatory efforts face challenges due to economic motivations for adulteration as well as technical, social, and infrastructure barriers.
Gururaj Pejavara Narayana, Subhangi Panigrahi, Suresh Kumar Kalakandan, Hema Vincent, Ashish Rawson   +4 more
wiley   +1 more source

The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways

Heliyon
In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects.
Arij Fouzat Hassan, Ola Hussein, Tara Al-Barazenji, Asma Allouch, Layla Kamareddine, Ahmed Malki, Ala‐Eddin Al Moustafa, Ashraf Khalil   +7 more
doaj   +1 more source

Optimization of Ultrasound‐Assisted Extraction of Seabuckthorn (Hippophae salicifolia) Seed Oil With the Use of Response Surface Methodology

Future Postharvest and Food, EarlyView.
Ultrasound‐assisted extraction (UAE) of seabuckthorn seed oil enhanced yield (17.95%), antioxidant activity (IC50: 5.25 μg/mL), and carotenoid content (266.63 mg/100 g). The oil, rich in unsaturated fatty acids (83.15%), exhibited superior quality, thermal stability, and potential applications in food, cosmetics, and pharmaceuticals, making UAE a ...
Mrityunjoy Das, Baikuntha Jyoti Gogoi, Ajitabh Bora, D. V. Kamboj, N. L. Raju   +4 more
wiley   +1 more source