Results 121 to 130 of about 10,547 (176)
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The influence of some sulfur-containing compounds on the toxicity of nitrogen mustards
Toxicology and Applied Pharmacology, 1963Abstract Measurements of the effect of nitrogen mustards on the cholinesterase activity of the small intestine of rats indicated that HN1 and HN2 cause a decrease in enzyme activity of the intestine that is maximal at 2–4 days after administration and is reversible after sublethal doses of the nitrogen mustards.
B E, HIETBRINK, A B, RAYMUND
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A chlorine-35 nuclear quadrupole resonance study of some nitrogen mustard compounds
Journal of Magnetic Resonance (1969), 1977Abstract A linear relationship has been established between the 35Cl nuclear quadrupole resonance frequency and the sum of the Hammet δ parameters for several aromatic nitrogen mustard compounds. This relationship is given by f q =1.024 ∑ i=1 n where fq is the quadrupole resonance frequency in megahertz, δ1 is the Hammett δ ...
David W Sheppard, Philip J Bray
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Carbohydrates and nitrogenous compounds in the honeydew of the mustard aphid, Lipaphis erysimi
Journal of Insect Physiology, 1970Abstract The chemical composition of the leaf sap of the radish, a host plant for the mustard aphid, Lipaphis erysimi , is compared with the composition of the honeydew that is excreted. The results indicate that the aphid utilizes sugars in a descending order of glucose, pentose sugars, fructose, and dextrins.
Harcharn Singh Sidhu, R.L. Patton
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Biochemical Pharmacology, 1960
Abstract The azo-mustard 4-di-2″-chloroethylaminoazobenzene-2′-carboxylic acid was found to be mutagenic in Drosophila melanogaster males. The mutagenic effect was found only in pre-meiotic germ cell stages and, of these, late spermatids were the most sensitive. Sterility or egg unhatchability was found to be due to aspermia.
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Abstract The azo-mustard 4-di-2″-chloroethylaminoazobenzene-2′-carboxylic acid was found to be mutagenic in Drosophila melanogaster males. The mutagenic effect was found only in pre-meiotic germ cell stages and, of these, late spermatids were the most sensitive. Sterility or egg unhatchability was found to be due to aspermia.
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International Journal of Radiation Oncology*Biology*Physics, 1986
Fifteen sulfur-containing compounds were examined for their ability to both protect normal hematopoietic stem cells (NCFU) from the cytotoxic effect of nitrogen mustard (HN2), and potentiate the cytotoxicity of HN2 to AKR leukemia cells (LCFU). All except four agents demonstrated some protection of NCFU with WR-2721 being most active.
F, Valeriote, H E, Grates
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Fifteen sulfur-containing compounds were examined for their ability to both protect normal hematopoietic stem cells (NCFU) from the cytotoxic effect of nitrogen mustard (HN2), and potentiate the cytotoxicity of HN2 to AKR leukemia cells (LCFU). All except four agents demonstrated some protection of NCFU with WR-2721 being most active.
F, Valeriote, H E, Grates
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Mutagenicity of heterocyclic nitrogen mustards (ICR compounds) in cultured mammalian cells.
Cancer research, 1978The mutagenicity of six heterocylic nitrogen mustards (ICR compounds) has been determined in a cultured mammalian cell system by use of resistance to the purine analog 6-thioguanine to select for mutation induction at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster ovary cells. The six compounds tested are ICR 191, 170, 292,
J P, O'Neill, J C, Fuscoe, A W, Hsie
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Journal of Pharmaceutical Sciences, 1961
The rates of formation of ethyleneimonium ion resulting only from the initial cyclization of a β-chloroethyl group of various nitrogen mustard compounds are reported. A polarographic technique was used for the quantitative determination of the ethyleneimonium ions.
H, ZALLEN, J E, CHRISTIAN, A M, KNEVEL
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The rates of formation of ethyleneimonium ion resulting only from the initial cyclization of a β-chloroethyl group of various nitrogen mustard compounds are reported. A polarographic technique was used for the quantitative determination of the ethyleneimonium ions.
H, ZALLEN, J E, CHRISTIAN, A M, KNEVEL
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Mutation Research/Genetic Toxicology, 1984
16 heterocyclic nitrogen mustards (ICR compounds), which were synthesized for use as possible antitumor agents by Creech and coworkers, were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1536, TA1537, TA1538, TA98 and TA100. The compounds were incorporated into the top agar at 5 doses: 0.5, 1, 2.5, 5 and 10 micrograms/plate.
D M, DeMarini +3 more
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16 heterocyclic nitrogen mustards (ICR compounds), which were synthesized for use as possible antitumor agents by Creech and coworkers, were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1536, TA1537, TA1538, TA98 and TA100. The compounds were incorporated into the top agar at 5 doses: 0.5, 1, 2.5, 5 and 10 micrograms/plate.
D M, DeMarini +3 more
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CLINICAL TRIAL OF A NEW NITROGEN-MUSTARD COMPOUND
The Lancet, 1956C, SELLEI +3 more
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The Synthesis Of Nitrogen Mustard Derivatives Of Some Steroids And Related Compounds.
1952PhD ; Chemistry ; University of Michigan, Horace H. Rackham School of Graduate Studies ; http://deepblue.lib.umich.edu/bitstream/2027.42/179112/2/0003761 ...
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