Results 111 to 120 of about 10,770 (170)
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International Journal of Radiation Oncology Biology Physics, 1986
Fifteen sulfur-containing compounds were examined for their ability to both protect normal hematopoietic stem cells (NCFU) from the cytotoxic effect of nitrogen mustard (HN2), and potentiate the cytotoxicity of HN2 to AKR leukemia cells (LCFU). All except four agents demonstrated some protection of NCFU with WR-2721 being most active.
Fred Valeriote
exaly +3 more sources
Fifteen sulfur-containing compounds were examined for their ability to both protect normal hematopoietic stem cells (NCFU) from the cytotoxic effect of nitrogen mustard (HN2), and potentiate the cytotoxicity of HN2 to AKR leukemia cells (LCFU). All except four agents demonstrated some protection of NCFU with WR-2721 being most active.
Fred Valeriote
exaly +3 more sources
New compounds: N-arylglyoxylohydroxamyl derivatives of nitrogen mustard
Journal of Pharmaceutical Sciences, 1967The synthesis and physical properties of some N,N - bis (2 - chloroethyl)arylglyoxylohy-droxamamides are described.
J P, Larocca, C A, Gibson
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Phosphorus-nitrogen compounds. 24. Phosphoramide mustard carrier derivatives
Journal of Medicinal Chemistry, 1984Diethylstilbestrol, psoralen, and propranolol were used as potential carrier molecules for selective concentrations of a nitrogen mustard moiety in breast, skin, and lung tissues, respectively. The propranolol derivative gave two racemic mixtures, which were tested to ascertain any differences in anticancer activity.
L A, Cates +3 more
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The influence of some sulfur-containing compounds on the toxicity of nitrogen mustards
Toxicology and Applied Pharmacology, 1963Abstract Measurements of the effect of nitrogen mustards on the cholinesterase activity of the small intestine of rats indicated that HN1 and HN2 cause a decrease in enzyme activity of the intestine that is maximal at 2–4 days after administration and is reversible after sublethal doses of the nitrogen mustards.
B E, HIETBRINK, A B, RAYMUND
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Carbohydrates and nitrogenous compounds in the honeydew of the mustard aphid, Lipaphis erysimi
Journal of Insect Physiology, 1970Abstract The chemical composition of the leaf sap of the radish, a host plant for the mustard aphid, Lipaphis erysimi , is compared with the composition of the honeydew that is excreted. The results indicate that the aphid utilizes sugars in a descending order of glucose, pentose sugars, fructose, and dextrins.
Harcharn Singh Sidhu, R.L. Patton
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Journal of Pharmaceutical Sciences, 1961
The rates of formation of ethyleneimonium ion resulting only from the initial cyclization of a β-chloroethyl group of various nitrogen mustard compounds are reported. A polarographic technique was used for the quantitative determination of the ethyleneimonium ions.
H, ZALLEN, J E, CHRISTIAN, A M, KNEVEL
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The rates of formation of ethyleneimonium ion resulting only from the initial cyclization of a β-chloroethyl group of various nitrogen mustard compounds are reported. A polarographic technique was used for the quantitative determination of the ethyleneimonium ions.
H, ZALLEN, J E, CHRISTIAN, A M, KNEVEL
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A chlorine-35 nuclear quadrupole resonance study of some nitrogen mustard compounds
Journal of Magnetic Resonance (1969), 1977Abstract A linear relationship has been established between the 35Cl nuclear quadrupole resonance frequency and the sum of the Hammet δ parameters for several aromatic nitrogen mustard compounds. This relationship is given by f q =1.024 ∑ i=1 n where fq is the quadrupole resonance frequency in megahertz, δ1 is the Hammett δ ...
David W Sheppard, Philip J Bray
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Biochemical Pharmacology, 1960
Abstract The azo-mustard 4-di-2″-chloroethylaminoazobenzene-2′-carboxylic acid was found to be mutagenic in Drosophila melanogaster males. The mutagenic effect was found only in pre-meiotic germ cell stages and, of these, late spermatids were the most sensitive. Sterility or egg unhatchability was found to be due to aspermia.
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Abstract The azo-mustard 4-di-2″-chloroethylaminoazobenzene-2′-carboxylic acid was found to be mutagenic in Drosophila melanogaster males. The mutagenic effect was found only in pre-meiotic germ cell stages and, of these, late spermatids were the most sensitive. Sterility or egg unhatchability was found to be due to aspermia.
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ChemInform Abstract: PHOSPHORUS‐NITROGEN COMPOUNDS. 24. PHOSPHORAMIDE MUSTARD CARRIER DERIVATIVES
Chemischer Informationsdienst, 1984AbstractDargestellt und auf Antitumor‐Aktivität untersucht werden die Verbindungen (I)‐(III).
L. A. CATES +3 more
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