Results 31 to 40 of about 30,782 (258)

Design, synthesis and in vitro cytotoxicity study of benzodiazepine-mustard conjugates as potential brain anticancer agents

Journal of Saudi Chemical Society, 2017
The combination of two pharmacological entities in a single compound has been utilized as a promising drug design strategy for site-specificity. So two nitrogen mustard agents were synthesized by conjugating mustard with the benzodiazepine nucleus in the
Rajesh K. Singh, D.N. Prasad, T.R. Bhardwaj   +2 more
doaj   +1 more source

Analysis of Volatile Components in Fuling Pickled Mustard Tuber during Spontaneous Fermentation by Non-targeted Metabolomics Based on HS-SPME-GC-MS/MS [PDF]

Shipin Kexue
To investigate the differences in volatile components during the processing of Fuling Zhacai, or pickled mustard tuber, with three stacked layers of mustard tuber and salt, gas chromatography-tandem mass spectrometry (GC-MS/MS)-based non-targeted ...
LU Chunxia, XU Junhao, YU Jie, YOU Xiaohui, CHEN Ya, LI Chaosheng, LI Hongmin, JI Yong, TANG Zonggui, LUO Luyun
doaj   +1 more source

The Role of Organic Peroxides in the Induction of Mutations [PDF]

, 1949
The discovery by Wyss, Stone, and Clark' that bacteria grown on a substrate recently exposed to ultra-violet light are subject to high mutation rates shows clearly that some meta-stable chemical substance, probably of no great complexity, is an ...
Cleland, George H., Dickey, Frank H., Lotz, Carol   +2 more
core   +1 more source

Nitrate-Dependent Iron Oxidation: A Potential Mars Metabolism [PDF]

, 2018
This work considers the hypothetical viability of microbial nitrate-dependent Fe2+ oxidation (NDFO) for supporting simple life in the context of the early Mars environment.
Abramov, Amils, Anand, Arevalo, Arnold, Arvidson, Bauermeister, Benz, Bibring, Bridges, Bridges, Bruce, Busigny, Byrne-Bailey, Cabrol, Canfield, Carlson, Carlson, Carr, Chakraborty, Chakraborty, Changela, Charlou, Chassefière, Chastain, Chaudhuri, Chevrier, Cockell, Cockell, Cockell, Comeau, Czaja, Dartnell, Edwards, Edwards, Edwards, Ehlmann, Ehlmann, Ehlmann, Ehrenreich, Emerson, Emerson, Emerson, Etique, Ettwig, Fassett, Filiberto, Fisk, Formisano, Fowler, Fox, Fox, Fox-Powell, Frydenvang, Gauger, Gendrin, Glavin, Grady, Gronstal, Grotzinger, Grotzinger, Hafenbradl, Hecht, Hedrich, Hicks, Hoefen, Hoehler, Hoppert, Hurowitz, Ilbert, Ionescu, Irwin, Jakosky, Jepsen, Johnson, Kappler, Kappler, Kappler, King, Kish, Klueglein, Klueglein, Konhauser, Konn, Kounaves, Kumaraswamy, Lack, Lalonde, Lanza, Laufer, Lopez-Reyes, Lovley, Lovley, Madigan, Mahaffy, Malin, Mangold, Manning, Martin, Martín-Torres, Marzo, McSween, McSween, Michalski, Millero, Ming, Ming, Miot, Miot, Miot, Miot, Miot, Miot, Miot, Miot, Mirvaux, Montoya, Morgan, Morris, Morris, Morris, Muehe, Myers, Nachon, Navarro-González, Nealson, Nie, Nixon, Nixon, Nixon, Oren, Osinski, Palucis, Pantke, Parnell, Pirajno, Popa, Raghoebarsing, Raiswell, Ramirez, Rampe, Rampe, Reimers, Revsbech, Roden, Santelli, Schieber, Schuerger, Schwenzer, Schwenzer, Schädler, Sephton, Sholes, Smith, Smith, Squyres, Squyres, Squyres, Steele, Stern, Stern, Stevens, Straub, Straub, Straub, Strohm, Summers, Summers, Summers, Sutter, Toporski, Tosca, Tosca, Tuff, Vaniman, Visscher, Wacey, Weber, Weber, Weber, Webster, Welhan, Wheat, Williams, Yen, Yen   +185 more
core   +4 more sources

ESTUDOS BIOFÍSICOS ENTRE BENDAMUSTINA, UM AGENTE ANTITUMORAL ALQUILANTE, E O DNA: CONTRIBUIÇÕES PARA O ENTENDIMENTO DO PROCESSO DE INTERAÇÃO [PDF]

Química Nova
Understanding the interactions between small ligands and (bio)macromolecules is essential for the development of bioactive compounds. This study investigated the interaction between CT-DNA (calf thymus-deoxyribonucleic acid) and bendamustine (BE), a ...
Victorya G. Silva Medeiros, Carla de A. Vital, Ari S. Guimarães, Isis M. Figueiredo, Josué Carinhanha C. Santos   +4 more
doaj   +1 more source

Effect of cytostatic drugs on microbial behaviour in membrane bioreactor system [PDF]

, 2010
The aim of this work is to evaluate the influence of cyclophosphamide and its principal metabolites (CPs) on microbial behaviour in a membrane bioreactor system. Two laboratory-scale membrane bioreactors (MBR) were run in parallel with a sludge retention
Albasi, Claire, Delgado, Luis Fernando, Gonzalez, Carlos, Schetrite, Sylvie   +3 more
core   +3 more sources

DNA crosslinking and biological activity of a hairpin polyamide–chlorambucil conjugate [PDF]

, 2003
A prototype of a novel class of DNA alkylating agents, which combines the DNA crosslinking moiety chlorambucil (Chl) with a sequence-selective hairpin pyrrole-imidazole polyamide ImPy-beta-ImPy-gamma-ImPy-beta-Dp (polyamide 1), was evaluated for its ...
Beerman, Terry A., Dervan, Peter B., Dziegielewska, Barbara, Dziegielewski, Jaroslaw, Wang, Yong-Dong, Wurtz, Nicholas R.   +5 more
core   +2 more sources

Glutathione S-conjugates as prodrugs to target drug-resistant tumors

Frontiers in Pharmacology, 2014
Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic detoxification in many species is the conjugation of activated xenobiotics to reduced glutathione (GSH) catalyzed by the glutathione-S-transferase (GST).
Emma E. Ramsay, Pierre J. Dilda
doaj   +1 more source

Cytotoxicity micropollutant removal in a crossflow membrane bioreactor [PDF]

, 2011
The application of membrane bioreactor (MBR) technology was investigated with the aim of evaluating its potential for cytostatic drug and cytotoxicity bioremoval. The toxicity removal was assessed from biomarker test. CP removal of up to 80% was achieved
Albasi, Claire, Delgado, Luis Fernando, Dorandeu, Christophe, Faucet-Marquis, Virginie, Marion, Bénédicte, Pfohl-Leszkowicz, Annie, Schetrite, Sylvie   +6 more
core   +2 more sources

Shifts in Soil Bacterial Communities as a Function of Carbon Source Used During Anaerobic Soil Disinfestation

Frontiers in Environmental Science, 2019
Anaerobic soil disinfestation (ASD) is an organic amendment-based management practice for controlling soil-borne plant pathogens. Pathogen suppression appears to be carbon source-dependent and mediated by bacteria that proliferate and produce volatile ...
Amisha T. Poret-Peterson, Sebastian Albu, Ali E. McClean, Daniel A. Kluepfel   +3 more
doaj   +1 more source