Results 41 to 50 of about 117,489 (150)

Metal‐Catalyzed Cross‐Coupling for the Synthesis of β‐Lactam Drugs and Related Chemical Probes

ChemMedChem, EarlyView.
This review focus on the use of transition metal cross‐coupling strategies for the synthesis of beta‐lactam derivatives. This manuscript encompasses the seminal studies for the synthesis of antibiotics up to the current need of accessing specific probes that are crucial for the detection of resistances.
Jules Bresson, Katie Burke, Mélanie Ethève‐Quelquejeu, Laura Iannazzo, Kevin Cariou   +4 more
wiley   +1 more source

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

ChemSusChem, Accepted Article.
This review critically examines the dual nature of chlorine as both an indispensable base chemical and a potential risk. Chlorine and its by‐product hydrogen chloride play essential roles in the production of pharmaceuticals, plastics, agrochemicals, and disinfectants.
Johannes Schwan, Merlin Kleoff, Gesa H. Dreyhsig, Patrick Voßnacker, Traute Fiedler, Marian Rosental, Sebastian Riedel   +6 more
wiley   +1 more source

Covalent Protein Adduction of Nitrogen Mustards and Related Compounds

, 2017
Chemical warfare agents continue to pose a global threat despite the efforts of the international community to prohibit their use in warfare. For this reason, improvement in the detection of these compounds remains of forensic interest. Protein adducts formed by the covalent modification of an electrophilic xenobiotic and a nucleophilic amino acid may ...
openaire   +3 more sources

Mercaptans in malodorants break disulfide bridges in human serum albumin and form adducts suitable as biomarkers of exposure in vitro

Drug Testing and Analysis, EarlyView.
Disulfide adducts of mercaptans with cysteine residues in human serum albumin were detected as tripeptides and dipeptides after proteolysis with proteinase K. All peptide adducts were detected simultaneously with a mass spectrometry‐based method working in the scheduled multiple reaction monitoring (sMRM) mode.
Paula Helena Sieber, Dirk Steinritz, Franz Worek, Harald John   +3 more
wiley   +1 more source

Genome Editing Technologies to Improve Health‐Related Phytocompounds in Crops

Food Frontiers, EarlyView.
ABSTRACT Due to rapid global population growth and the resulting significant increase in food demand, the world is facing an epidemic of malnutrition. Although yield improvement remains one of the main targets of breeding programs, much attention is being paid to the nutritional aspects of crops, including nutrients and bioactive compounds that are ...
Maria Dellino, Claudio de Giovanni, Monica Marilena Miazzi, Cinzia Montemurro, Domenica Nigro   +4 more
wiley   +1 more source

Harnessing Jasminum Bioactive Compounds: Updated Insights for Therapeutic and Food Preservation Innovations

Food Frontiers, EarlyView.
Jasminum bioactives improve food preservation by providing antimicrobial and antioxidant effects, especially when incorporated into active packaging, edible films, and nanoformulations that enhance stability and controlled release. They also offer many pharmacological benefits, including anti‐inflammatory, neuroprotective, and wound‐healing properties.
Antonio Rescigno, Paolo Zucca, Stefania Peddio, Sriranjani Srikanth, Niharika Prakash Kaushik, Nanjangud Venkatesh Anil Kumar, Gerardo Leyva‐Gómez, Dorota Kregiel, Ibrahim M. Abu‐Reidah, Surjit Sen, Krishnendu Acharya, William N. Setzer, Marta Palma‐Morales, Miquel Martorell, Daniela Calina, Celia Rodríguez‐Pérez, Javad Sharifi‐Rad, William C. Cho   +17 more
wiley   +1 more source

Mechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be ...
Madison Owens, Anita Thyagarajan, Jeffrey B. Travers, Ravi P. Sahu   +3 more
wiley   +1 more source

Valorizing sunflower processing byproducts for a sustainable bioeconomy: Fungal fermentation and characterization of hulls and screens

JSFA reports, EarlyView.
Abstract Background Sunflower hulls (SFH) and screens (SFS) are byproducts of sunflower seed processing with limited alternative applications. This study investigates the submerged fermentation of SFH and SFS by Aureobasidium pullulans‐(Ap), Trichoderma reesei‐(Tr), Aspergillus oryzae‐(Ao), Neurospora crassa‐(Nc), and Aspergillus niger‐(An) to alter ...
Santosh Thapa, William R. Gibbons, Bishnu Karki   +2 more
wiley   +1 more source

Eco‐Friendly Synthesis of Selenium Nanoparticles via Sternbergia candida: Enhancing Antioxidant Defense and Mitigating Salt Stress in Pepper (Capsicum annuum L.) Plants

ChemistryOpen, EarlyView.
Sternbergia candida serves as a flexible reducing agent for the synthesis of SeNPs utilizing an economical and ecologically safe extract. Applications of selenium have demonstrated that plants cultivated in salinity preserve proper osmotic conditions and minimize cellular damage, as evidenced by photosynthetic pigments, proline, and MDA data.
Senem Kanber, Mahmut Yildiztekin, Mehmet Firat Baran   +2 more
wiley   +1 more source

Development of G–Ag and C–Ag Nanoparticle‐Based Biosensor for Benzoic Acid Detection

ChemistryOpen, EarlyView.
This study investigates an electrochemical sensor for the highly sensitive detection of benzoic acid on a glassy carbon electrode using silver nanoparticles produced by green synthesis (G–Ag) and chemical synthesis (C–Ag) methods. This study shows that the nanoparticles obtained through biological synthesis are as effective as those synthesized by the ...
Mehmet Selcuk Erdogan, Muhammed Bekmezci, Nihal Yigit Ertas, Ramazan Bayat, Fatih Sen   +4 more
wiley   +1 more source