Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues [PDF]
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia.
Keigo Endo +6 more
core +1 more source
An epigenetic role for maternally inherited piRNAs in transposon silencing [PDF]
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic information.
Aravin, A. A. +5 more
core +2 more sources
Inhibitory activities of monocyclic nitroimidazoles against Mycobacterium tuberculosis (Mtb) deazaflavin-dependent nitroreductase (DDN) were modeled by using docking, pharmacophore alignment and comparative molecular similarity indices analysis (CoMSIA ...
Pyung Keun Myung +3 more
doaj +1 more source
Antecedentes: La Tricomoniasis es una enfermedad de transmisión sexual, causada por un protozoo que recibe el nombre de Trichomonas vaginalis, que pertenece a la familia de Phylum Sarcomastigophora. T.
Zhon, Shuwen
core
Imaging tumour hypoxia with positron emission tomography. [PDF]
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance.
A L Harris +99 more
core +2 more sources
NITROIMIDAZOLES XI [I]. SYNTHESES OF DISUBSTITUTED NITROIMIDAZOLYLQUINOLINES [PDF]
Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-
doaj
QT-Interval Prolongation in the Treatment of Drug-Resistant Tuberculosis
The review analyzes the research articles, guidelines, and clinical trial results on the effect of fluoroquinolones, bedaquiline, nitroimidazoles, and clofazimine on QTc prolongation.
A. V. Kukurika
doaj +1 more source
The reverse protraction factor in the induction of bone sarcomas in radium-224 patients [PDF]
More than 50 bone sarcomas have occurred among a collective of about 800 patients who had been injected in Germany after World War II with large activities of radium-224 for the intended treatment of bone tuberculosis and ankylosing spondylitis.^In an ...
Chmelevsky, D. +3 more
core +1 more source
Synthesis and Biological Activity of Peptide Derivatives of Iodoquinazolinones/Nitroimidazoles
Two substituted quinazolinyl/imidazolyl-salicylic acids 5, 6 were synthesized bythe reaction of 6-iodo-2-methylbenzoxazin-4-one/5-nitroimidazole with 5-aminosalicylicacid (5-ASA).
Rakesh Yadav, Anil Kumar, Rajiv Dahiya
doaj +1 more source
Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity [PDF]
Twenty nine original 3-nitroimidazo[1,2-a]pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized.
Azas, Nadine +24 more
core +4 more sources

