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On the mutagenicity of nitroimidazoles
Mutation Research/Reviews in Genetic Toxicology, 1981Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
Voogd, CE
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Obstetrical & Gynecological Survey, 1982
Nitroimidazoles, including metronidazole, tinidazole and ornidazole, are low molecular weight antimicrobial compounds with excellent activity against anaerobic microorganisms. These compounds are usually bactericidal at low concentrations and their spectrum of activity encompasses almost all the anaerobic bacteria and some capnophylic organisms.
F P, Tally, B, Goldin, N E, Sullivan
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Nitroimidazoles, including metronidazole, tinidazole and ornidazole, are low molecular weight antimicrobial compounds with excellent activity against anaerobic microorganisms. These compounds are usually bactericidal at low concentrations and their spectrum of activity encompasses almost all the anaerobic bacteria and some capnophylic organisms.
F P, Tally, B, Goldin, N E, Sullivan
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The mutagenic action of nitroimidazoles II. Effects of 2-nitroimidazoles
Mutation Research/Environmental Mutagenesis and Related Subjects, 1975The 2-nitroimidazoles Ro-71051 (N-benzyl-2-nitro-1-imidazole-acetamide) and Ro-5-9963 (3(2-nitro-1-imidazolyl)-1,2-propanediol) increased the mutation rate of a Klebsiella pneumoniae mutant to streptomycin-resistance including streptomycin-dependence in Luria and Delbruck's fluctuation test in concentrations of 0.05-1 mM and 0.02-0.2 mM respectively ...
C E, Voogd +2 more
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Nitroimidazoles and imaging hypoxia
European Journal of Nuclear Medicine, 1995Decreased tissue oxygen tension is a component of many diseases. Although hypoxia can be secondary to a low inspired pO2 or a variety of lung disorders, the commonest cause is ischemia due to an oxygen demand greater than the local oxygen supply. In tumors, low tissue pO2 is often observed, most often due to a blood supply inadequate to meet the tumor ...
A, Nunn, K, Linder, H W, Strauss
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Modification of chemotherapy by nitroimidazoles
International Journal of Radiation Oncology*Biology*Physics, 1984The potentiation of chemotherapeutic agents by radiation sensitizers has been extensively studied for several years. There is little doubt that the effectiveness of certain anti-cancer drugs, primarily alkylating agents, can readily be enhanced both in vitro and in vivo through the addition of a sensitizer.
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Nitroimidazoles as chemotherapeutic agents
1983During the last two decades, or, more precisely, ever since the introduction of metronidazole into therapy, nitroimidazoles as a class of compounds have attracted much attention. Nevertheless, no adequate review of this chemical class has appeared in literature, even though a large number of reviews on the chemotherapy of protozoal diseases refer to ...
M D, Nair, K, Nagarajan
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Chemistry & Biodiversity, 2006
AbstractA series of 5‐alkylamino and 5‐alkylsulfanyl derivatives of 1‐aryl‐2‐alkyl‐4‐nitro‐1H‐imidazoles 12–21, 31, and 34 were synthesized by a simple method with the aim to develop novel HIV non‐nucleoside reverse transcriptase inhibitors (NNRTIs). All the new compounds were tested against HIV‐1 and HIV‐2 in MT‐4 cells.
Najim A, Al-Masoudi +4 more
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AbstractA series of 5‐alkylamino and 5‐alkylsulfanyl derivatives of 1‐aryl‐2‐alkyl‐4‐nitro‐1H‐imidazoles 12–21, 31, and 34 were synthesized by a simple method with the aim to develop novel HIV non‐nucleoside reverse transcriptase inhibitors (NNRTIs). All the new compounds were tested against HIV‐1 and HIV‐2 in MT‐4 cells.
Najim A, Al-Masoudi +4 more
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Permeability of Nitroimidazoles in Rat Cortex
Chemotherapy, 2009The right cerebral hemisphere of the rat was perfused in situ by retrograde bolus infusion of some nitroimidazole drugs into the external carotid artery. The right jugular vein served to collect blood samples. Drugs were continuously measured in the right cortex by microvoltametric electrodes and in blood samples by high-performance liquid ...
A, Meulemans +4 more
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