Results 131 to 140 of about 4,252 (181)
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1982
The development in recent years of nitroimidazoles as chemotherapeutic agents has been extensive. The interest in this class of compounds apparently was raised in 1955 by the elucidation of the structure of the antibiotic Azomycin by Nakamura(l) and the discovery of the in vivo activity of 5-nitro-imidazoles against Trichomonas vaginalis(2). Since then
D. E. Schwartz, W. Hofheinz
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The development in recent years of nitroimidazoles as chemotherapeutic agents has been extensive. The interest in this class of compounds apparently was raised in 1955 by the elucidation of the structure of the antibiotic Azomycin by Nakamura(l) and the discovery of the in vivo activity of 5-nitro-imidazoles against Trichomonas vaginalis(2). Since then
D. E. Schwartz, W. Hofheinz
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Electrochemical behaviour of 4-nitroimidazole and 2-methyl-5-nitroimidazole
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1982Abstract The electrochemical behaviour of the title imidazoles (HRNO 2 ) has been investigated in dimethylformamide and acetonitrile by polarography, cyclic voltammetry and controlled-potential electrolysis and coulometry. The above nitroimidazoles present similar behaviour, displaying two reduction waves paralleled by two reduction peaks in linear ...
S. Roffia, C. Gottardi, E. Vianello
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Pharmacokinetics and Pharmacodynamics of the Nitroimidazole Antimicrobials
Clinical Pharmacokinetics, 1999Metronidazole, the prototype nitroimidazole antimicrobial, was originally introduced to treat Trichomonas vaginalis, but is now used for the treatment of anaerobic and protozoal infections. The nitroimidazoles are bactericidal through toxic metabolites which cause DNA strand breakage.
K C, Lamp +3 more
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Tinidazole: A nitroimidazole antiprotozoal agent
Clinical Therapeutics, 2005Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
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Clinical experience with nitroimidazoles as radiosensitizers
International Journal of Radiation Oncology*Biology*Physics, 1982Abstract Clinical experience at Mount Vernon now includes 248 patients who have been given misonidazole (Ro 07–0582) and 57 patients who have been given desmethylmisonidazole (Ro 05–9963). Work with Ro 03–8799 is now beginning. The promise of chemical agents to improve the results of the radiotherapy is dependent upon effective levels of ...
S, Dische +4 more
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The synthesis of azomycin (2-Nitroimidazole)
Experientia, 1965La sintesi del 2-nitroimidazolo e del 1-metil-2-nitroimidazolo per diazotasione e reasione di Gattermann a partire dai corrispondenti 2-aminoimidasoli dimostra che, in determinate condizioni, questi ultimi si comportano come composti a carattere aromatico.
G C, LANCINI, E, LAZZARI
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Radiosensitization of solid tumors by nitroimidazoles
International Journal of Radiation Oncology*Biology*Physics, 1978Abstract Recently a new class of drugs has been identified by Adams et al. at the Gray Laboratory, which act as specific radiosensitizers of hypoxic cells. This sensitization results from their high electron affinity, and their presence at the time of irradiation abolishes the protection afforded by hypoxia.
J, Denekamp, J F, Fowler
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Studies on the action of nitroimidazole drugs. The products of nitroimidazole reduction.
Biochemical pharmacology, 1983The electron requirements for the electrolytic reduction of misonidazole, metronidazole and 4(5)-nitroimidazole have been measured using high-resolution coulometry. Eleven of the labelled final reduction products of metronidazole (a 5-nitroimidazole) have been separated by high-performance liquid chromatography and identified. These appear to be formed
R J, Knox, R C, Knight, D I, Edwards
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Nitroimidazoles as modifiers of nitrosourea pharmacokinetics
International Journal of Radiation Oncology*Biology*Physics, 1984We have studied the effect of a number of nitroimidazole sensitizers of varying lipophilicity on the pharmacokinetics of CCNU in mice. It was found that the effectiveness of these compounds in producing pharmacokinetic effects correlated directly with their lipophilicity, viz.
F Y, Lee, P, Workman
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Acta Crystallographica Section C Crystal Structure Communications, 1996
X-ray analysis confirmed the configuration of the title N1-alkylated C4-nitroimidazole inhibitor. The plane of the imidazole ring, sitting on an axis of the trityl propeller, bisects the angle between two phenyl rings, while the nitro group extends over the third.
E, Skrzypczak-Jankun, R G, Kurumbail
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X-ray analysis confirmed the configuration of the title N1-alkylated C4-nitroimidazole inhibitor. The plane of the imidazole ring, sitting on an axis of the trityl propeller, bisects the angle between two phenyl rings, while the nitro group extends over the third.
E, Skrzypczak-Jankun, R G, Kurumbail
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