Results 41 to 50 of about 18,203 (158)

[Nitrosamines].

Medycyna pracy, 1998
The paper reviews data on the property and mechanism of toxicologic effects of nitrosamines. Particular attention is turned to metabolism and carcinogenesis of these compounds in view of their concentration in human environment.
J, Jabłoński, J, Moniuszko-Jakoniuk, D, Sieńko   +2 more
openaire   +1 more source

Studies on the Formation of Nitrosamines (VII)

Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1974
The reaction products of glycocyamine, one of the naturally occurring guanidines, and nitrite under acidic conditions were explored. The main product was identified as carboxymethylnitrosourea, a derivative of hydantoic acid whose secondary amino group was nitrosated, by elemental analysis and NMR spectrum.
Takashi YAMADA, Miyako YAMAMOTO, Akio TANIMURA   +2 more
openaire   +8 more sources

Microbial degradation of nitrosamines. I. Inducible breakdown of nitrosamines.

NIPPON SUISAN GAKKAISHI, 1979
In order to investigate the microbial degradation of nitrosamines, the degrading activity of three strains of non-pathogenic microorganisms, i. e., Rhizopus oryzae, Streptococcus cremoris, and Sccaromyces rouxii was examined. These microorganism, were active in degrading NDMA, NDEA, NDPA, NPYR, and NPIP, NDPA bejng degraded more rapidly than the other ...
HARADA, Katsuhiko, YAMADA, Kinjiro
openaire   +3 more sources

XXIII.—On aromatic nitrosamines [PDF]

J. Chem. Soc., Trans., 1878
n ...
openaire   +1 more source

Using Celery Powder in a Semi-Dry Fermented Sausage ‘Heat-Treated Sucuk’: Nitrosamine Formation, Lipid Oxidation, and Volatile Compounds

Foods
This study investigated the effect of using celery powder (CP) as source of pre-converted nitrite (treatments: A: 150 mg/kg NaNO2, B: 100 mg/kg NaNO2 + CP as 50 mg/kg NaNO2 equivalent, C: 50 mg/kg NaNO2 + CP as 100 mg/kg NaNO2 equivalent, D: CP as 150 mg/
Zeynep Feyza Yılmaz Oral, Mükerrem Kaya, Güzin Kaban   +2 more
doaj   +1 more source

Nitrosamine contamination of pharmaceuticals: Cases in Japan, formation mechanisms, detection methods, regulatory perspectives, and insights

Journal of Pharmaceutical and Biomedical Analysis Open
In recent years, mutagenic nitrosamines, such as N-nitrosodimethylamine, have been detected in medicine. This has led to global product recalls and long-term supply suspensions by pharmaceutical companies and consequent clinical impacts.
Genichiro Tsuji, Hidetomo Yokoo, Yosuke Demizu, Yasuhiro Abe, Sayaka Masada, Nahoko Uchiyama, Tomoaki Tsutsumi, Eiichi Yamamoto   +7 more
doaj   +1 more source

N-nitrosamine risk assessment in pharmaceuticals: Where are we from a regulatory point of view in 2025?

Journal of Pharmaceutical and Biomedical Analysis Open
N-nitrosamines have been a concern for decades due to their potential mutagenicity and widespread occurrence across various matrices. While evidence suggests carcinogenicity in animals, their potential carcinogenicity in humans has prompted their initial
Yue Zhang, Joëlle Widart, Eric Ziemons, Philippe Hubert, Cédric Hubert   +4 more
doaj   +1 more source

Chemopreventive effect of omega-3 polyunsaturated fatty acids and atorvastatin in rats with bladder cancer

Tumor Biology, 2017
Bladder cancer remains a huge concern for the medical community because of its incidence and prevalence rates, as well as high percentage of recurrence and progression. Omega-3 polyunsaturated fatty acids and atorvastatin proved anti-inflammatory effects
Nahla E El-Ashmawy, Eman G Khedr, Hoda A El-Bahrawy, Samar M Al-Tantawy   +3 more
doaj   +1 more source

Development and Validation of N-nitrosamine Rejection Mathematical Model Using a Spiral-wound Reverse Osmosis Process

Chemical Engineering Transactions, 2016
In this paper, a one-dimensional mathematical model based on coupled differential and algebraic equations has been developed for analysing the separation mechanism of a N-nitrosamine in a spiral-wound reverse osmosis process.
M.A. Al-Obaidi, C. Kara-Zaïtri, I.M. Mujtaba   +2 more
doaj   +1 more source

Mitigating matrix effects for LC-MS/MS quantification of nitrosamine impurities in rifampin and rifapentine

Journal of Pharmaceutical and Biomedical Analysis Open
Since the discovery of potentially mutagenic nitrosamine impurities in pharmaceuticals in 2018, liquid chromatography-mass spectrometry (LC-MS) methods have been widely applied for the trace level quantification of nitrosamines.
Qiyao Li, Qun Xu, Nadine Lo, Allan T. Leeks, Jr., Mark Han, Marcela Nefliu, John T. Simpson, Jennifer L. Belsky   +7 more
doaj   +1 more source