Results 21 to 30 of about 18,203 (158)

A Review on the Role of Lactic Acid Bacteria in the Formation and Reduction of Volatile Nitrosamines in Fermented Sausages

Foods, 2023
Nitrosamines are N-nitroso compounds with carcinogenic, mutagenic and teratogenic properties. These compounds could be found at certain levels in fermented sausages. Fermented sausages are considered to be a suitable environment for nitrosamine formation
Selen Sallan, Zeynep Feyza Yılmaz Oral, Mükerrem Kaya   +2 more
doaj   +1 more source

Defensive Role of Vitamin E Against Nitrosamine-Induced Harm to Testicular Tissues in Male BALB/C Albino Mice

مجلة الانبار للعلوم البيطرية, 2023
Nitrosamines are toxic substances that induce oxidative stress. Oxidative stress results from an imbalance between the formation of free radicals (ROS) and their removal from the body and is a direct or indirect cause of a variety of diseases ...
Atyaf Shakir Ahmed, Nedhal ibrahime lateff   +1 more
doaj   +1 more source

Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters

Pharmaceutics
The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug ...
Chetan P. Kulkarni, Jia Yang, Megan L. Koleske, Giovanni Lara, Khondoker Alam, Andre Raw, Bhagwant Rege, Liang Zhao, Dongmei Lu, Lei Zhang, Lawrence X. Yu, Robert A. Lionberger, Kathleen M. Giacomini, Deanna L. Kroetz, Sook Wah Yee   +14 more
doaj   +1 more source

Risk of cervical cancer among female autoworkers exposed to metalworking fluids

Scandinavian Journal of Work, Environment & Health, 2012
OBJECTIVES: Cervical cancer is caused by human papilloma virus (HPV). However, only a small proportion of women infected with HPV, progress to cervical cancer. Other co-factors must therefore be necessary to cause cervical cancer.
Nicole Betenia, Sadie Costello, Ellen A Eisen   +2 more
doaj   +1 more source

Pentoxifylline modulation hepatotoxicity and apoptosis induced by nitrosamine in rats

Biomedical and Biotechnology Research Journal, 2020
Background: Pentoxifylline (PEN) is a xanthine derivative with different functional characteristics including dilution of blood and increase in tissue oxygenation rate. Nitrosamines (NITs) are well known as strong carcinogenic agents. This study attempts
Mohammad Reza Salahshoor, Cyrus Jalili, Amir Abdolmaleki, Shiva Roshankhah   +3 more
doaj   +1 more source

NMR Assignments of Six Asymmetrical N-Nitrosamine Isomers Determined in an Active Pharmaceutical Ingredient by DFT Calculations

Molecules, 2022
N-nitrosamines, which are well-known pro-mutagens, are found in drugs, pickled food and tobacco. Therefore, controlling their concentrations is very important.
Hao-Yue Guan, Yu-Fei Feng, Bai-Hao Sun, Jian-Zhao Niu, Qing-Sheng Zhang   +4 more
doaj   +1 more source

Analysis of nine nitrosamines relevant to occupational safety by ion mobility spectroscopy and preliminary gas chromatographic separation

Journal of Chromatography Open, 2023
Nitrosamines have been identified as a probable human carcinogen and thus are of high concern in many manufacturing industries and various matrices (for example pharmaceutical, cosmetic and food products, workplace air or potable- and wastewater).
Jana Hinz, Tessema F. Mekonnen, Jonas Bergrath, Savanna Sewell, Yannic Schneck, Michaela Wirtz, Ursula Telgheder   +6 more
doaj   +1 more source

Evaluation of Microbial and Sensory Properties of Red Meat Sausage Formulated with Carmine Dye and Cumin Essential Oil as Nitrate Substitute [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Nitrate and nitrite have a long history of use in processed meat products and several studies have been done about their replacement with healthier alternatives.
Leila Nateghi, Masoumeh Moslemi, Nader Karimian Khosroshahi   +2 more
doaj   +1 more source

Quantitative Analysis of NDMA in Drug Products: A Proposed High-Throughput Approach Using Headspace–SIFT-MS

AppliedChem
Since the initial 2018 recall of angiotensin receptor blockers due to unacceptable levels of mutagenic N-nitrosodimethylamine (NDMA) impurity, numerous drug products delivering diverse active pharmaceutical ingredients (APIs) have been recalled ...
Mark J. Perkins, Colin J. Hastie, Vaughan S. Langford   +2 more
doaj   +1 more source

A genome-wide portrait of pervasive drug contaminants

Scientific Reports, 2021
Using a validated yeast chemogenomic platform, we characterized the genome-wide effects of several pharmaceutical contaminants, including three N-nitrosamines (NDMA, NDEA and NMBA), two related compounds (DMF and 4NQO) and several of their metabolites. A
Joseph Uche Ogbede, Guri Giaever, Corey Nislow   +2 more
doaj   +1 more source