Results 1 to 10 of about 2,581 (174)

Early life exposure to N-nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice [PDF]

Nature Communications
N-Nitrosodimethylamine (NDMA) is a probable human carcinogen found in contaminated pharmaceuticals and drinking water, yet the impact of age on NDMA susceptibility remains poorly understood.
Lindsay B. Volk, Monét Norales, Callie Karjane, Joshua J. Corrigan, Alper J. Alcaraz, Lee J. Pribyl, Nicolette A. Bugher, Megan Blawas, Isabella Dulski, Einthavy Arunachalam, Nina Gubina, Emily Michelsen, Kannammai Pichappan, Natalya Yakimchuk, Matilda Swanson, Duanduan Ma, Stuart S. Levine, Desiree L. Plata, Robert G. Croy, Leona D. Samson, John M. Essigmann, Carole L. Yauk, Sebastian E. Carrasco, Bevin P. Engelward   +23 more
doaj   +2 more sources

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis [PDF]

Discover Oncology
Background N-Nitrosodimethylamine (NDMA), classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC), is ubiquitous in drinking water, processed foods, and certain pharmaceuticals. Emerging epidemiological evidence links
Zhiyao Shi, Xiaokun Yang, Yichan Liu, Yu Gao, Jiajia Liu, Limin Wang, Xixing Wang   +6 more
doaj   +2 more sources

N-nitrosodimethylamine (NDMA) and some prescribed medicines: A mini-review

International Journal of Medicine and Health Development, 2022
Recently, there have been notices of drug recalls by different pharmaceutical companies. This is based on the finding of high level of N-nitrosodimethylamine (NDMA) in such medications.
Chidiebere V Ugwueze, Chidiebele M Ezeude, Chinweuba M Abonyi, Chidimma B Nwatu, Kingsley N Ukwaja, Ekenechukwu E Young   +5 more
doaj   +2 more sources

Mechanistic Insights into NDMA Adsorption onto Selected Pollutants and Their Removal via Direct Rapid Sand Filtration and After Enhanced Coagulation [PDF]

Molecules
N-nitroso dimethylamine (NDMA), a common nitrogen disinfection by-product and carcinogen, can be removed using rapid sand filtration (RSF) after coagulation; however, its removal mechanism has not been extensively studied.
Olubunmi M. Olukowi, Tian Tian, Xie Yan, Yuejun Zhang   +3 more
doaj   +2 more sources

The role of chloramine species in NDMA formation

Water Research, 2018
N-nitrosodimethylamine (NDMA), a probable human carcinogen disinfection by-product, has been detected in chloraminated drinking water systems. Understanding its formation over time is important to control NDMA levels in distribution systems. The main objectives of this study were to investigate the role of chloramine species (i.e., monochloramine and ...
Daekyun Kim, Wilson Beita-Sandí, Tanju Karanfil   +2 more
exaly   +5 more sources

N-Nitrosodimethylamine as an Emerging Environmental Contaminant: Sources, Analytical Advances, and Ecotoxicological and Human Health Risks [PDF]

International Journal of Analytical Chemistry
Over the last few years, N-nitrosodimethylamine (NDMA) has become a significant environmental contaminant with both anthropogenic and natural sources.
Besnaci Sana, Grara Nedjoud, Khadri Sihem, Hemmami Hadia, Ali Abbas Aslam, Mohammed H. AL Mughram, Khalid J. Alzahrani, Masooma Irfan, Mahmood Ahmed   +8 more
doaj   +2 more sources

Enhancing Catalytic Removal of N-Nitrosodimethylamine from Drinking Water Matrices with One-Step-Carbonized Ferric Ammonium Citrate [PDF]

Nanomaterials
N-Nitrosodimethylamine (NDMA) is a widely recognized disinfection by-product that poses significant carcinogenic risks in drinking water. Conventional methods for NDMA removal, such as nanofiltration and reverse osmosis membranes, have limited efficacy ...
Jing Lv, Lingyue Zhang, Jialu Li, Yuting Zhang, Ruofan Wang, Rui Tang, Jianchao Wang, Mei Hong, Na Liu   +8 more
doaj   +2 more sources

A Comparative Study in Metformin Tablet Quality Assessment: LC-MS and LC-MS/MS Method Quantification of N-Nitroso-Dimethylamine in the Presence of Dimethyl Formamide [PDF]

International Journal of Analytical Chemistry
N-nitroso-dimethylamine (NDMA, acceptable daily intake limit 96 ng/day), a probable human carcinogenic impurity, has been reported in metformin formulations.
Gereziher Sibhat, Mariame A. Hassan, Indra K. Reddy, Mansoor A. Khan, Ziyaur Rahman   +4 more
doaj   +2 more sources

Influence of sheep tail fat and autochthonous starter culture on the formation of volatile nitrosamines in sucuk [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023
The study aimed to investigate the effect of sheep tail fat (STF) on the volatile nitrosamines in a dry fermented sausage (sucuk) with/without autochthonous starter culture (Lactiplantibacillus plantarum GM77 and Staphylococcus xylosus GM92).
Selen SALLAN
doaj   +1 more source

Selective and sensitive GC-MS analysis of carcinogenic N-nitrosodimethylamine in pharmaceuticals using a magnetic coconut carbon composite as a solid-phase extraction sorbent

Journal of Taibah University for Science, 2023
The aim of the present research was to develop a magnetic coconut carbon composite (Fe2O3/Fe3O4@CNC) as a solid-phase extraction (SPE) sorbent for the analysis of carcinogenic N-nitrosodimethylamine (NDMA) in pharmaceuticals.
Hazim M. Ali, Ibrahim Hotan Alsohaimi, Mohammad Rizwan Khan, Ibrahim A. Naguib, Rosa Busquets, Pravej Alam, Bayan E. Ainousah, Mohammed Gamal   +7 more
doaj   +1 more source