A Robust and Universal LC-MS/MS Method for Determination of N-Nitrosodimethylamine in Pharmaceuticals Using a C30 Column. [PDF]
J Sep SciABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
An B +9 more
europepmc +2 more sources
Losartan API and Nitrosamines Impurities-Stability Profile Investigation Using HPLC, LC-MS, and In Silico Assessment. [PDF]
J Sep SciABSTRACT Nitrosamines are potent genotoxic impurities with well reported mutagenic and carcinogenic effects. Their presence has been detected in several pharmaceutical products among them losartan, an angiotensin II receptor blocker. Considering the risks already reported for these impurities, the present study aimed to investigate the influence of ...
Martini PRR +6 more
europepmc +2 more sources
Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N-Nitrosamines. [PDF]
Environ Mol MutagenABSTRACT Conducting S9‐mediated preincubations at slightly acid pHs (e.g., pH 5.0 to pH 6.5) has been reported to enhance the mutagenicity of small‐molecule nitrosamines in the Ames test. In this study, we have evaluated the effect of adjusting the preincubation mix used in the Enhanced Ames Test (EAT) from pH 7.4 to pH 6.0 and supplying the activation
Bishop ME +11 more
europepmc +2 more sources
Effect of celery powder as an alternative nitrite source on some quality properties and nitrosamine formation in sucuk [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 This study aimed to determine the effects of celery powder (nitrate converted to nitrite) and cooking time on the formation of nitrosamine in sucuk. The microbiological and physicochemical properties were also investigated.
Zeynep Feyza YILMAZ ORAL
doaj +1 more source
Distribution and health risk assessment of N-nitrosodimethylamine in urban drinking water in China
环境与职业医学, 2021 BackgroundNitrosamines, especially N-nitrosodimethylamine (NDMA), are highly carcinogenic and frequently detected in drinking water systems in China, indicating potential human health risk through drinking water.ObjectiveThis study aims to analyze the ...
Hongquan CAI +3 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2023 N-nitrosodimethylamine (NDMA) is an environmental and food contaminant, but limited data to concern whether NDMA has adverse effects on the brain. This study first determined the concentration of NDMA in foods from aquaculture markets in Shenzhen, then ...
Wei Liu +13 more
doaj +1 more source
Fate of Nitrosodimethylamine (NDMA) [PDF]
WIT Transactions on Ecology and the Environment, 2008 Nitrosodimethylamine (NDMA) is a known animal carcinogen and is noted as a probable human carcinogen by the USEPA with a lifetime risk of contracting cancer of 10 at 0.7 ng/L. This contaminant is of rising concern since its production is linked to disinfection processes at water and wastewater treatment plants.
K. Jahan +5 more
openaire +1 more source
The effect of the combination of rosemary extract and green tea extract on nitrosamine content, microbiological, physicochemical and sensorial properties of heat-treated sucuk [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 In this study, it was aimed to determine the effect of using rosemary extract together with green tea extract (RE/GTE) on nitrosamine content and quality characteristics of heat-treated sucuk.
Zeynep Feyza YILMAZ ORAL, Güzin KABAN
doaj +1 more source
The Occurrence of N -nitrosodimethylamine (NDMA) in Swimming Pools: An Overview [PDF]
Environmental Health Insights, 2021 The occurrence of several disinfectant byproducts has been investigated in swimming pools. Until now, there are only a few studies on nitrosamine, particularly N-nitrosodimethylamine in swimming pool water. This could be due to the lack of a suitable method that is sensitive enough for the measurement of N-nitrosodimethylamine in pool waters.
Saheed Mustapha +6 more
openaire +3 more sources
Factors affecting N-nitrosodimethylamine formation from poly(diallyldimethyl-ammonium chloride) degradation during chloramination [PDF]
Royal Society Open Science, 2018 Poly(diallyldimethylammonium chloride) (polyDADMAC) has been shown to be an important precursor of the probable human carcinogen N-nitrosodimethylamine (NDMA) when in contact with chloramine. In this study, we conducted an orthogonal experiment design to
Siying Tan +3 more
doaj +1 more source