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N-Nitrosodimethylamine as an Emerging Environmental Contaminant: Sources, Analytical Advances, and Ecotoxicological and Human Health Risks [PDF]

International Journal of Analytical Chemistry
Over the last few years, N-nitrosodimethylamine (NDMA) has become a significant environmental contaminant with both anthropogenic and natural sources.
Besnaci Sana, Grara Nedjoud, Khadri Sihem, Hemmami Hadia, Ali Abbas Aslam, Mohammed H. AL Mughram, Khalid J. Alzahrani, Masooma Irfan, Mahmood Ahmed   +8 more
doaj   +3 more sources

The Occurrence of -nitrosodimethylamine (NDMA) in Swimming Pools: An Overview [PDF]

Environmental Health Insights, 2021
The occurrence of several disinfectant byproducts has been investigated in swimming pools. Until now, there are only a few studies on nitrosamine, particularly N -nitrosodimethylamine in swimming pool water.
Saheed Mustapha, Jimoh Oladejo Tijani, Muhammed Muhammed Ndamitso, Saka Ambali Abdulkareem, Shuaib Damola Taye, Abdul Kabir Mohammed, Azeezah Taiwo Amigun   +6 more
doaj   +2 more sources

Association of N-nitrosodimethylamine exposure with cognitive impairment based on the clues of mice and humans [PDF]

Frontiers in Aging Neuroscience, 2023
N-nitrosodimethylamine (NDMA) is an environmental and food contaminant, but limited data to concern whether NDMA has adverse effects on the brain. This study first determined the concentration of NDMA in foods from aquaculture markets in Shenzhen, then ...
Wei Liu, Wei Liu, Wei Liu, Jia Huang, Jia Huang, Zhi Yan, Yankui Lin, Guanqin Huang, Xiao Chen, Zhou Wang, Zhou Wang, Peter S. Spencer, Jianjun Liu, Jianjun Liu   +13 more
doaj   +2 more sources

N-Nitrosodimethylamine Contamination in the Metformin Finished Products [PDF]

Molecules, 2020
A GC–MS/MS method with EI ionization was developed and validated to detect and quantify N-nitrosodimethylamine (NDMA) and seven other nitrosamines in 105 samples of metformin tablets from 13 different manufactures.
Adam Zmysłowski, Iza Książek, Arkadiusz Szterk   +2 more
doaj   +2 more sources

The Finding of N-Nitrosodimethylamine in Common Medicines. [PDF]

Oncologist, 2020
The FDA has ordered the withdrawal of all ranitidine products from the marketplace based on recent findings of increased and unacceptable levels of N-nitrosodimethylamine (NDMA). This commentary reviews the sources and properties of NDMA, assesses the dangers it poses, and suggests measures to mitigate contamination.
Adamson RH, Chabner BA.
europepmc   +4 more sources

N ‐nitrosodimethylamine‐Contaminated Valsartan and Risk of Cancer: A Nationwide Study of 1.4 Million Valsartan Users

Journal of the American Heart Association, 2022
Background Since July 2018, numerous lots of valsartan have been found to be contaminated with N‐nitrosodimethylamine (NDMA). We aimed to assess the association between exposure to valsartan products contaminated with NDMA and the risk of cancer. Methods
Imène Mansouri, Jeremie Botton, Mahmoud Zureik   +2 more
exaly   +3 more sources

Metformin drugs under simulated gastric conditions can generate high nitrite-dependent levels of N-nitrosodimethylamine [PDF]

Scientific Reports
N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA), group 2A carcinogens, were detected in finished drug products, including metformin, ranitidine, sartans and other drugs which caused multiple recalls in the USA and Europe. Important studies
George Cristian Georgescu, Mircea Cretu-Stancu, Octavian Bucur   +2 more
doaj   +2 more sources

N-Nitrosodimethylamine-Contaminated Valsartan and the Risk of Cancer—A Longitudinal Cohort Study Based on German Health Insurance Data. [PDF]

Dtsch Arztebl Int, 2021
N-Nitrosodimethylamine (NDMA), classified as a probable human carcinogen, has been found as a contaminant in the antihypertensive drug valsartan. Potentially carcinogenic effects associated with the consumption of NDMAcontaminated valsartan have not yet been analyzed in large-scale cohort studies.
Gomm W, Röthlein C, Schüssel K, Brückner G, Schröder H, Heß S, Frötschl R, Broich K, Haenisch B.   +8 more
europepmc   +4 more sources

Factors affecting N-nitrosodimethylamine formation from poly(diallyldimethyl-ammonium chloride) degradation during chloramination [PDF]

Royal Society Open Science, 2018
Poly(diallyldimethylammonium chloride) (polyDADMAC) has been shown to be an important precursor of the probable human carcinogen N-nitrosodimethylamine (NDMA) when in contact with chloramine. In this study, we conducted an orthogonal experiment design to
Siying Tan, Shaojie Jiang, Xiaoyu Li, Qiuhong Yuan   +3 more
doaj   +2 more sources

Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis [PDF]

Discover Oncology
Background N-Nitrosodimethylamine (NDMA), classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC), is ubiquitous in drinking water, processed foods, and certain pharmaceuticals. Emerging epidemiological evidence links
Zhiyao Shi, Xiaokun Yang, Yichan Liu, Yu Gao, Jiajia Liu, Limin Wang, Xixing Wang   +6 more
doaj   +2 more sources