Results 11 to 20 of about 18,203 (158)
Saudi Pharmaceutical Journal, 2023 Over the last two years, global regulatory authorities have raised safety concerns on nitrosamine contamination in several drug classes, including angiotensin II receptor antagonists, histamine-2 receptor antagonists, antimicrobial agents, and ...
Wisut Wichitnithad +3 more
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Effect of Menthol on SFRP1 Expression Level and HIF-1α/VEGF Signaling in Diethylnitrosamine-induced Kidney Damage in Male Mice [PDF]
Journal of Ardabil University of Medical Sciences, 2023 Background: Many scientific Researches have shown that diethylnitrosamine, which is used to induce liver carcinoma, has destructive effects on the kidney. Menthol is a monoterpene type with antioxidant, anti-inflammatory, and anti-cancer effects.
Samaneh Alijanian +2 more
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Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation
Pharmaceutics, 2023 Risk control for nitrosamine impurities in drug products is currently a major challenge in the industry. Nitrosamines can form during drug product manufacturing and storage through the reaction of nitrites with amine-containing APIs or impurities.
Alberto Berardi +2 more
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Effect of celery powder as an alternative nitrite source on some quality properties and nitrosamine formation in sucuk [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023 This study aimed to determine the effects of celery powder (nitrate converted to nitrite) and cooking time on the formation of nitrosamine in sucuk. The microbiological and physicochemical properties were also investigated.
Zeynep Feyza YILMAZ ORAL
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Foods, 2022 In a rpsL gene mutation experiment, the mutagenicity of the nitrosamine compounds N-diethylnitrosamine (NDEA) and N-dipropylnitrosamine (NDPA) was investigated at the cellular level, as well as with PCR (polymerase chain reaction) and RCA (rolling-circle
Xueling Peng +2 more
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Applied Sciences, 2022 Nowadays, the use of tobacco biomass as an energy source is being valued. Therefore, it is important to know the processes that take place during combustion and pyrolysis, as well as the substances that are formed.
Javier Asensio +4 more
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Разработка и регистрация лекарственных средств, 2020 Introduction. N-nitrosamine compounds are potent genotoxic agents in animal species and some are classified as probable human carcinogens. This group of genotoxic impurities was found in drugs such as angiotensin II receptor blockers, histamine H1 ...
P. P. Shchetinin +2 more
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Molecules, 2022 The purpose of this research study was to develop an analytical method for the quantification of 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4] triazolo [4,3-a] pyrazine (7-nitroso impurity), which is a potential genotoxic impurity.
Hari Naga Prasada Reddy Chittireddy +7 more
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Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats
Research in Pharmaceutical Sciences, 2019 Nitrosamines are well-known carcinogenic agents. Humans are exposed to nitrosamines in various ways, the most important of which is the diet. Pentoxifylline is a xanthine derivative, which is used as a drug that inhibits inflammatory factors, reduces ...
Cyrus Jalili +3 more
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Nitrosodimethylamine impurities in metformin drug products: Physician insight
Journal of Diabetology, 2021 Metformin is a high-dose antidiabetic drug and most widely used first-line therapeutic agent for the management of type 2 diabetes mellitus (T2DM).
Chetan Doshi +4 more
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