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A Genetic Analysis of Nitrosative Stress
Biochemistry, 2009Nitrosative stress is induced by pathophysiological levels of nitric oxide (NO) and S-nitrosothiols (e.g., S-nitrosoglutathione, GSNO) and arises, at least in significant part, from the nitrosylation of critical protein Cys thiols (S-nitrosylation) and metallocofactors.
Matthew W, Foster +4 more
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An Apoptotic Model for Nitrosative Stress
Biochemistry, 2000Nitric oxide overproduction has been implicated in the pathogenesis of many disorders, including artherosclerosis, neurodegenerative diseases, inflammatory and autoimmune diseases, and cancer. The common view holds that nitric oxide-induced cellular injury is caused by oxidative stress.
J P, Eu, L, Liu, M, Zeng, J S, Stamler
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Oxidative Stress and Nitrosative Stress
2016Cardiomyocytes generate multiple forms of short half-life molecules known as reactive oxygen and reactive nitrogen species (ROS) and acting as signaling molecules (RNS). However, under certain conditions the balance between formation of oxygen radicals and degradation of them is severely affected resulting in oxidative stress that significantly ...
Rainer Schulz, Fabio Di Lisa
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Current Medicinal Chemistry, 2020
Dysfunction of the endocannabinoid system ( ES ) has been identified in nonalcoholic fatty liver disease (NAFLD) and associated metabolic disorders. Cannabinoid receptor 1 (CB1) expression is largely dependent on nutritional status.
Bojan Jorgačević +7 more
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Dysfunction of the endocannabinoid system ( ES ) has been identified in nonalcoholic fatty liver disease (NAFLD) and associated metabolic disorders. Cannabinoid receptor 1 (CB1) expression is largely dependent on nutritional status.
Bojan Jorgačević +7 more
semanticscholar +1 more source
Oxidative and Nitrosative Stress
2017Oxidative stress plays a critical role in the pathophysiology of stroke and results when there is a disruption of the homeostatic balance between cellular oxidants and antioxidants. Reactive oxygen species (ROS), although critical for normal physiologic processes, are detrimental if produced in excess.
J.M. Modak, L.D. McCullough
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Oxidative modifications in nitrosative stress
Nature Structural Biology, 1998The molecular basis of redox sensitivity in proteins is not well understood. Here we consider a continuum of NO- and O2-related modifications of cysteine residues that constitute biological signaling events on the one hand and hallmarks of nitrosative and oxidative stresses on the other.
Jonathan S. Stamler, Alfred Hausladen
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Oxidative and nitrosative stress in ammonia neurotoxicity
Neurochemistry International, 2013Increased ammonia accumulation in the brain due to liver dysfunction is a major contributor to the pathogenesis of hepatic encephalopathy (HE). Fatal outcome of rapidly progressing (acute) HE is mainly related to cytotoxic brain edema associated with astrocytic swelling.
Marta, Skowrońska, Jan, Albrecht
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Acta Psychiatrica Scandinavica, 2019
Obsessive–compulsive disorder (OCD) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS) have been implicated.
A. Maia +6 more
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Obsessive–compulsive disorder (OCD) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS) have been implicated.
A. Maia +6 more
semanticscholar +1 more source
Oxidative & nitrosative stress in depression: Why so much stress?
Neuroscience & Biobehavioral Reviews, 2014Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the pathophysiology of unipolar and bipolar depression. These disorders are characterized inter alia by lowered antioxidant defenses, including: lower levels of zinc, coenzyme Q10, vitamin E and glutathione; increased lipid peroxidation; damage to proteins, DNA and ...
Steven Moylan +10 more
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Nitrosative Stress and Pathogenesis of Insulin Resistance
Antioxidants & Redox Signaling, 2006Insulin resistance is a major causative factor for type 2 diabetes and is associated with increased risk of cardiovascular disease. Despite intense investigation for a number of years, molecular mechanisms underlying insulin resistance remain to be determined.
Masao, Kaneki +3 more
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