Results 81 to 90 of about 25,127 (201)

Linking dynamic cerebral autoregulation and inhibitory executive function: Role of modifiable behaviours

Experimental Physiology, EarlyView.
Abstract Dynamic cerebral autoregulation (dCA) stabilises cerebral blood flow (CBF) against rapid fluctuations in perfusion pressure and may serve as a key physiological mediator of cognitive function. Inhibitory executive function, a core domain essential for goal‐directed behaviour, is influenced by modifiable lifestyle factors such as physical ...
Hayato Tsukamoto, Damian M. Bailey
wiley   +1 more source

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome

JACC: Basic to Translational Science, 2018
Summary: Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress.
Sven Y. Surikow, BHlthSc (Hons), Thanh H. Nguyen, MD, MMedSci, PhD, Irene Stafford, BSc, Matthew Chapman, BSc, MClinSci, DMU, CEPIA, Sujith Chacko, MBBS, Kuljit Singh, MBBS, PhD, Giovanni Licari, BSc, PhD, Betty Raman, MBBS, Darren J. Kelly, PhD, Yuan Zhang, MBBS, PhD, Mark T. Waddingham, BSc (Hons), PhD, Doan T. Ngo, BPharm, PhD, Alexander P. Bate, Su Jen Chua, MBBS, Michael P. Frenneaux, MD, John D. Horowitz, MBBS, BMedSci(Hons), PhD   +15 more
doaj   +1 more source

Carotid artery dissection linked to intermittent apnoeic swimming: A case–control study

Experimental Physiology, EarlyView.
Abstract Internal carotid artery (ICA) dissection is a rare and potentially devastating cause of cerebral ischaemia, initiated by an intimal tear or rupture of the vasa vasorum, that can lead to an intraluminal thrombus, vascular stenosis, occlusion, or dissecting aneurysm formation.
Damian M. Bailey, Richard G. Davies, Brenig L. Gwilym, Benjamin S. Stacey, Danny Walmsley, Michael H. Lewis, Josip Butkovic, Ivan Mumlek, Brad Perry, Zvonomir Vrselja, Shigehiko Ogoh, James A. Pawelczyk, Mohamad Bashir, Richard D. White, Ian M. Williams   +14 more
wiley   +1 more source

PLIN2 Mediates Neuroinflammation and Oxidative/Nitrosative Stress via Downregulating Phosphatidylethanolamine in the Rostral Ventrolateral Medulla of Stressed Hypertensive Rats

Journal of Inflammation Research, 2021
Shutian Zhang,1,* Li Hu,2,* Chengzhi Han,1 Renhui Huang,1 Kokwin Ooi,1 Xinyi Qian,1 Xiaorong Ren,1 Dechang Chu,3 Haili Zhang,3 Dongshu Du,4 Chunmei Xia1 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan ...
Zhang S, Hu L, Han C, Huang R, Ooi K, Qian X, Ren X, Chu D, Zhang H, Du D, Xia C   +10 more
doaj  

A comparison of normobaric and hypobaric hypoxia effects on cerebrovascular response pre and post maximal exercise

Experimental Physiology, EarlyView.
Abstract A lack of consensus remains on whether normobaric hypoxia (NH) and hypobaric hypoxia (HH) may differentially impact physiological factors affecting cerebrovascular regulation, particularly with an additional strenuous exercise component. We sought to compare the acute effects of NH and HH on global cerebral blood flow (gCBF) at an altitude ...
Rachel Turner, Giovanni Vinetti, Giacomo Strapazzon, Hannes Gatterer   +3 more
wiley   +1 more source

VEGF inhibitor‐induced vascular dysfunction involves redox‐sensitive PARP activation and SIRT1 disruption

Experimental Physiology, EarlyView.
Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves, Rheure Alves‐Lopes, Augusto C. Montezano, Rhian M. Touyz   +3 more
wiley   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

The Neuroprotective Role of Indole-3-Propionic Acid in Migraine Pathophysiology

Medicina
Background and Objectives: Migraine is a leading cause of disability worldwide, with complex pathophysiological mechanisms involving oxidative and nitrosative stress.
Dilek Agircan, Seyhan Taskin, Murat Cekic, Hakim Celik   +3 more
doaj   +1 more source

Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to pollutant nanoparticles has been increasingly investigated due to concerns about their potential effects on placental function and pregnancy outcomes. Maternal inhalation of pollutant nanoparticles can result in a pro‐inflammatory response; particles can also translocate across the alveolus epithelial barrier
Katherine L. Bethell, Andrew C. Povey, Edward D. Johnstone, Peter T. Ruane   +3 more
wiley   +1 more source

Gold Nanoparticles Coated With the Antimicrobial Peptide Os‐C(W5): Anticandidal and Biological Activity

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Gold nanoparticles conjugated with a tick‐derived antimicrobial peptide, Os‐C(W5), demonstrate enhanced proteolytic stability and potent antifungal activity against Candida albicans biofilms and planktonic cells. These non‐cytotoxic nanoconjugates represent a promising biocompatible strategy for combating resistant fungal infections while maintaining ...
P. J. Palm, R. R. Chirombo, C. K. Chiramba, J. C. Serem, H. Taute, M. van der Walt, A. R. M. Gaspar, M. J. Bester   +7 more
wiley   +1 more source