Results 91 to 100 of about 26,472 (210)

Modulation of Wnt/β‐Catenin Pathway by Aesculus hippocastanum Extract Enhances Temozolomide Sensitivity in Glioblastoma Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Glioblastoma (GB) is a highly aggressive brain tumour with a poor prognosis and limited responsiveness to standard chemotherapy, particularly temozolomide (TMZ), due to intrinsic resistance mechanisms. This study investigates the potential of Aesculus hippocastanum, known as horse chestnut extract (HCE), to enhance the therapeutic efficacy of ...
Sarah Adriana Scuderi, Alessio Ardizzone, Deborah Mannino, Nicoletta Palermo, Fabiola De Luca, Antonio Catalfamo, Michela Campolo, Emanuela Esposito, Irene Paterniti   +8 more
wiley   +1 more source

Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis [PDF]

, 2003
Peer ...
Hamalainen, M, Hukkanen, M, Kankuri, E, Kivilaakso, E, Moilanen, E, Salmenpera, P, Vapaatalo, H   +6 more
core   +1 more source

Environmental modulators of vascular physiology and inflammation

Experimental Physiology, Volume 111, Issue 2, Page 321-334, 1 February 2026.
Abstract Environmental factors play a crucial role in modulating vascular inflammation, contributing significantly to the development of atherosclerosis and cardiovascular disease. This review synthesizes current evidence on how various environmental exposures influence vascular function and inflammation, with a focus on pollutants such as particulate ...
Anusha N. Seneviratne, Anne Majumdar, Kalpana Surendranath, Mark R. Miller   +3 more
wiley   +1 more source

A rapid and selective mass spectrometric method for the identification of nitrated proteins. [PDF]

, 2008
The nitration of protein tyrosine residues represents an important posttranslational modification during development, oxidative stress, and biological aging.
AMORESANO, ANGELA, Chiappetta G, MARINO, GENNARO, PUCCI, PIETRO   +3 more
core   +1 more source

Palmitoylethanolamide (PEA) regulates cell cycle progression and promotes an anti‐inflammatory transcriptomic signature in C2C12 skeletal muscle cells

Physiological Reports, Volume 14, Issue 4, February 2026.
Abstract Palmitoylethanolamide (PEA) is an endogenous lipid mediator with immunomodulatory actions, yet its effects in skeletal muscle remain poorly defined. We examined whether PEA influences myogenesis and profiled the acute transcriptomic response of differentiated C2C12 myotubes to 10 μM PEA. PEA decreased myotube number (90.3 ± 10.6 vs. 112.6 ± 10.
Paige L. Cole, Scott H. Gillham, Mark R. Viggars, Graeme L. Close, Daniel J. Owens   +4 more
wiley   +1 more source

Pterin-6-aldehyde, Xanthine Oxidase Inhibitor and Superoxide Scavenger, Directly React with Peroxynitrite

Pteridines, 1999
The effect of pterin-6-aldehyde (P6A), xanthine oxidase inhibitor and superoxide scavenger, on the production of nitrotyrosine as a footprint of tyrosine nitration by peroxynitrite, was compared with that of uric acid, a peroxynitrite scavenger.
Mori Hiroko, Arai Toshiyuki, Ishii Hisanari, Endo Nobuyuki, Suzuki Toshinori, Fukudal Kazuhiko   +5 more
doaj   +1 more source

Putative 3-nitrotyrosine detoxifying genes identified in the yeast Debaryomyces hansenii: In silico search of regulatory sequences responsive to salt and nitrogen stress

Electronic Journal of Biotechnology, 2017
Background: During salt stress, the yeast Debaryomyces hansenii synthesizes tyrosine as a strategy to avoid the oxidation of proteins. Tyrosine reacts with nitrogen radicals to form 3-nitrotyrosine.
Daniela E. Castro, Miguel Murguía-Romero, Patricia E. Thomé, Antonio Peña, Marissa Calderón-Torres   +4 more
doaj   +1 more source

Atmospheric chemistry of bioaerosols: heterogeneous and multiphase reactions with atmospheric oxidants and other trace gases. [PDF]

, 2016
Advances in analytical techniques and instrumentation have now established methods for detecting, quantifying, and identifying the chemical and microbial constituents of particulate matter in the atmosphere.
Estillore, Armando D, Grassian, Vicki H, Trueblood, Jonathan V   +2 more
core   +2 more sources

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

Clinical-pathogenetic and prognostic value of the nitrotyrosine level in the blood serum of patients with coronavirus disease (COVID-19) with pneumonia

Patologìâ
The aim of the research is to determine the clinical-pathogenetic and prognostic value of nitrotyrosine levels in the blood serum of patients with COVID-19 with pneumonia in the development of oxygen dependence and the risk of fatal outcome. Materials
O. V. Riabokon, I. O. Kuliesh, I. F. Bielenichev, Yu. Yu. Riabokon   +3 more
doaj   +1 more source