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The Systemic Evaluation and Clinical Significance of Immunological Function for Advanced Lung Cancer Patients [PDF]
, 2010 Background and objective The actual evaluation of immunological function is significant for studing the tumor development and devising a treatment in time.
Hui ZHANG +12 more
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Veterinary Dermatology, Volume 36, Issue 3, Page 234-282, June 2025.Background – Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives – To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler +9 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2023 目的 研究再生障碍性贫血(AA)病人外周血NK细胞及其受体表达的变化，探讨NK细胞在AA发病机制中的作用。方法 利用流式细胞术检测28例AA病人(其中SAA 9例，NSAA 19例)外周血NK细胞功能，包括NK细胞数量，活化性受体NKG2D,抑制性受体NKG2A,穿孔素，颗粒酶β的表达，T淋巴细胞亚群及与造血指标的相关性分析，另有18例健康志愿者为对照组。结果 AA病人外周血NK细胞数，NKG2D,颗粒酶表达减少，与对照组比较差异有统计学意义 ...
孔令环 +6 more
doaj
The effect and mechanism of IL-1 R II / IL-1 RAcp in Autoimmune Myocarditis [PDF]
, 2016 【目的】白介素-1（IL-1）是一种T淋巴细胞激活因子，大量研究报道，在心肌炎急性期表达量明显升高。白介素1受体II型（IL-1RII）可以招募白介素1受体辅助蛋白（IL-1RAcp），从而拮抗IL-1β的作用。本课题目的为评估IL-1RII和IL-1RAcp的重组质粒对大鼠自身免疫性心肌炎（EAM）的作用，并进一步探讨其机制，为心肌炎的临床治疗提供理论基础。 【方法】首先在临床实验中，我们选取厦门市心血管病医院诊断明确的心肌炎住院患者28例，应用bio ...
宋颖
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Veterinary Dermatology, Volume 35, Issue 6, Page 595-604, December 2024.Background – Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode‐of‐action requires further research. Objective – To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme‐linked ...
Robert Ward +9 more
wiley +1 more source
, 2018 妊娠第37周前分娩的现象被称为早产。目前,全球每年约有1500万早产儿出生,其中100万早产儿在出生后的1个月内死亡。因此,早产作为一个全球性的问题,为社会带来了严重的负担。探索早产发生的机制,寻找有效的预防方法,是目前亟待解决的科学问题。文章围绕影响母胎界面微环境的3个主要因素即胎儿滋养层细胞、子宫蜕膜和母胎界面免疫细胞,详细阐述母胎界面微环境改变在早产发生中的作用机制。国家重点研发计划 ...
孟楠, 张思亚, 王海滨, 黄琳
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Veterinary Dermatology, Volume 35, Issue 5, Page 524-535, October 2024.Background – Cytological detection of acantholytic keratinocytes (acantholytic cells [AC]) helps to identify canine pemphigus foliaceus (cPF) yet AC also occurs in superficial pyoderma (SP), the main differential diagnosis. Hypothesis/Objectives – To compare selected cytomorphological features of cPF and SP and to establish cytological diagnostic ...
Tyler S. Spriggs +3 more
wiley +1 more source
Mechanistic Analysis of Immunomodulation by Human Induced Pluripotent Stem Cells Derived Mesenchymal Stem Cells in Mice [PDF]
, 2015 背景：间充质干细胞是具有自我更新能力和分化能力的组织细胞前体细胞，能够分化为一系列的间质细胞，包括成骨细胞、成软骨细胞、脂肪细胞、肌细胞和内皮细胞等。细胞治疗是再生医学发展的一个重要分支。越来越多的研究发现，间充质干细胞能够修复组织损伤，达到一定治疗效果。因此，间充质干细胞被视为天然组织工程材料的重要种子细胞，具有广阔的应用前景。此外，间充质干细胞具有负性免疫调节能力。在体外共培养条件下，间充质干细胞能够抑制免疫细胞功能，包括抑制T细胞反应，抑制树突状细胞的成熟和抗原提成，抑制B细胞激活和增殖 ...
李成林
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Amplification of Ovis aries papillomavirus type 2 DNA from an ovine cutaneous fibropapilloma
Veterinary Dermatology, Volume 35, Issue 2, Page 226-229, April 2024.Seven of 60 Perendale sheep within a flock developed single or multiple exophytic masses on their distal hind limbs. A mass was excised from one sheep and histological evaluation revealed epidermal and mesenchymal proliferation, papillomavirus‐induced keratinocyte changes and marked keratohyalin clumping.
John S. Munday +2 more
wiley +1 more source
HUVECs Promote the Proliferation of iPS-MSCs by FAM3B [PDF]
, 2016 间充质干细胞（mesenchymalstemcells，MSCs）存在于一个血管周微环境中，在这个微环境内，内皮细胞（endothelialcells，ECs）与MSCs互相作用，调控MSCs的表型和增殖，从而在MSCs的血管生成作用和治疗应用方面起重要作用。然而，MSCs受到来源、年龄、健康等多方面的影响，不能满足大规模的使用需求。诱导多能干细胞来源的间充质干细胞（inducedpluripotentstemcell-derivedMSCs，iPS-MSCs）可能会是一个有前景的替代性干细胞来源。但是，
冷云
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