Results 41 to 50 of about 113,543 (162)

Antibacterial and anticancer activity of two NK-lysin-derived peptides from the Antarctic teleost Trematomus bernacchii [PDF]

, 2023
: The NK-lysin antimicrobial peptide, first identified in mammals, possesses both antibacterial and cytotoxic activity against cancer cell lines.
A.R. Taddei, Gerdol, M., Porcelli, F., Buonocore, F., F. Porcelli, P.R. Saraceni, M. Sanguinetti, S. Picchietti, Fausto, A. M., Taddei, A. R., Borocci, S., A.M. Fausto, Scapigliati, G., M. Gerdol, G. Scapigliati, A. Miccoli, S. Borocci, Bugli, F., Sanguinetti, M., F. Bugli, Saraceni, P. R., Picchietti, S., Miccoli, A., F. Buonocore, Buonocore, Francesco, Borocci S, Fausto AM, Saraceni PR, Bugli F, Porcelli, Fernando, Picchietti S, Picchietti, Simona, Taddei AR, Borocci, Stefano, Miccoli Andrea, Fausto, Anna Maria, Buonocore F, Scapigliati, Giuseppe, Porcelli Fernando, Sanguinetti M, Taddei, Anna Rita, Gerdol M, Scapigliati G   +42 more
core   +1 more source

Comparative evaluation of antimicrobial activity of human granulysin, bovine and porcine NK-lysins against Shiga toxin-producing Escherichia coli O157:H7.

PLoS ONE, 2023
Shiga toxin-producing Escherichia coli (STEC) O157:H7 (O157) is a foodborne pathogen causing human disease ranging from hemorrhagic colitis and hemolytic uremic syndrome to kidney failure, while remaining harmless to cattle, its primary reservoir.
Erika N Biernbaum, Rohana P Dassanayake, Eric M Nicholson, Indira T Kudva   +3 more
doaj   +1 more source

Oral Delivery of Bacillus subtilis Expressing Chicken NK-2 Peptide Protects Against Eimeria acervulina Infection in Broiler Chickens

Frontiers in Veterinary Science, 2021
Chicken NK-lysin peptide 2 (cNK-2) is a natural lytic peptide with direct cytotoxicity against many apicomplexan parasites including Eimeria. Developing an effective oral delivery strategy to express cNK-2 in the intestine, where Eimeria parasites ...
Samiru S. Wickramasuriya, Inkyung Park, Youngsub Lee, Woo H. Kim, Woo H. Kim, Chris Przybyszewski, Cyril G. Gay, Jolieke G. van Oosterwijk, Hyun S. Lillehoj   +8 more
doaj   +1 more source

Genomic Structure and Tissue Expression of the NK-Lysin Gene Family in Bison [PDF]

Journal of Heredity, 2018
Antimicrobial peptides (AMPs) are a class of natural peptides with varying numbers of amino acids. They are principal components of innate immunity in vertebrates, encoding natural antibiotics and providing a protective response against a broad range of microbes including those responsible for tuberculosis, an important disease in bison.
Mi Ok, Lee, Lauren, Dobson, Brian W, Davis, Loren, Skow, James, Derr, James E, Womack   +5 more
openaire   +2 more sources

Costimulatory Molecules CD80/86 Trigger Non-Specific Cytotoxic Cell of Nile tilapia (Oreochromis niloticus) to Kill CIK Cells

Fishes, 2022
The teleost non-specific cytotoxic cell (NCC), as the evolutionary precursors of NK cells, is an important cytotoxic cell population in the innate immune system of teleost.
Yu Huang, Zhengsi Chen, Ruitao Xie, Kwaku Amoah, Bei Wang, Jia Cai, Yishan Lu, Jichang Jian   +7 more
doaj   +1 more source

Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells. [PDF]

Proc Natl Acad Sci U S A, 2012
NK-lysin is an effector protein of the innate immune system and an important component of host protection. We isolated a SNP in the NK-lysin coding sequence among different chicken breeds.
Lee MO, Kim EH, Jang HJ, Park MN, Woo HJ, Han JY, Womack JE.   +6 more
europepmc   +2 more sources

Effects of Newcastle Disease Virus Infection on Chicken Intestinal Intraepithelial Natural Killer Cells

Frontiers in Immunology, 2018
The intestinal intraepithelial natural killer cells (IEL-NK) are among the earliest effectors of antiviral immunity in chicken. Unfortunately, their role during Newcastle disease virus (NDV) infection remains obscure.
Mostafa Abdolmaleki, Swee Keong Yeap, Swee Keong Yeap, Sheau Wei Tan, Dilan Amila Satharasinghe, Muhammad Bashir Bello, Mohammad Zareian Jahromi, Mohd Hair Bejo, Mohd Hair Bejo, Abdul Rahman Omar, Abdul Rahman Omar, Aini Ideris, Aini Ideris   +12 more
doaj   +1 more source

Bacillus subtilis Expressing Chicken NK-2 Peptide Enhances the Efficacy of EF-1α Vaccination in Eimeria maxima-Challenged Broiler Chickens

Animals, 2023
This study was conducted to investigate the synergistic effects of orally delivered B. subtilis-cNK-2 on vaccination with rEF-1α against E. maxima infection in broiler chickens.
Youngsub Lee, Inkyung Park, Samiru S. Wickramasuriya, Hyun S. Lillehoj   +3 more
doaj   +1 more source

NK-lysin-induced damage to M. bovis plasma membrane.

, 2018
Mycoplasma bovis was incubated with PBS (A: control), 30 μM NK2A (B) or 30 μM NK2C (C) at 37°C for 60 min and processed for TEM. M. bovis incubated with NK-lysin peptides show damaged membranes as evidenced by ghost cells (triangles in panel B) and ...
Rohana P. Dassanayake (2802847), Karen B. Register (618336), Daniel Samorodnitsky (327419), Timothy A. Reinhardt (330115), Shollie M. Falkenberg (4379413), Eric M. Nicholson (159301)   +5 more
core   +1 more source

Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides. [PDF]

PLoS ONE, 2017
The methanogenic archaeon Methanomassiliicoccus luminyensis strain B10T was isolated from human feces just a few years ago. Due to its remarkable metabolic properties, particularly the degradation of trimethylamines, this strain was supposed to be used ...
Corinna Bang, Tim Vierbuchen, Thomas Gutsmann, Holger Heine, Ruth A Schmitz   +4 more
doaj   +1 more source