Evaluation of the Immunomodulatory Activity of the Chicken NK-Lysin-Derived Peptide cNK-2. [PDF]
Sci Rep, 2017 AbstractChicken NK-lysin (cNK-lysin), the chicken homologue of human granulysin, is a cationic amphiphilic antimicrobial peptide (AMP) that is produced by cytotoxic T cells and natural killer cells. We previously demonstrated that cNK-lysin and cNK-2, a synthetic peptide incorporating the core α-helical region of cNK-lysin, have antimicrobial activity ...
Kim WH, Lillehoj HS, Min W.
europepmc +5 more sources
Saposin fold revealed by the NMR structure of NK-lysin
Natural Structural Biology, 1997 NK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a structure has been determined.
Liepinsh, E +3 more
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Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion [PDF]
Marine Drugs, 2019 Global health is under attack by increasingly-frequent pandemics of viral origin. Antimicrobial peptides are a valuable tool to combat pathogenic microorganisms.
Alberto Falco +5 more
doaj +2 more sources
Candidacidal activity of shortened synthetic analogs of amoebapores and NK-lysin
Medical Microbiology and Immunology, 1999 Natural antimicrobial peptides and synthetic analogs thereof have emerged as compounds with potentially significant therapeutical application against human pathogens. Amoebapores are 77-residue peptides with cytolytic and antibacterial activity considered to act by forming ion channels in cytoplasmic membranes of the victim cells.
J, Andrä, M, Leippe
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Effects of low-dose dietary antimicrobial peptide Scy-hepc on disease resistance in Larimichthys crocea under secondary infection [PDF]
BMC MicrobiologyBackgroud Secondary infection by Vibrio parahaemolyticus, triggered by Cryptocaryon irritans, has become one of the most difficult diseases to control in Larimichthys crocea aquaculture due to its complex pathogens and diverse infection mechanisms ...
Hang Sun +8 more
doaj +2 more sources
Journal of Biomolecular Structure and Dynamics, 2016 NK-lysins are antimicrobial peptides (AMPs) that participate in the innate immune response and also have several pivotal roles in various biological processes. Such multifunctionality is commonly found among intrinsically disordered proteins. However, NK-lysins have never been systematically analyzed for intrinsic disorder.
Yacoub, Haitham A. +3 more
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Applied Sciences, 2016 Antimicrobial peptides (AMPs) are small peptides and play important roles in host innate immune response against microbial invasion. Aquatic animals secrete different kinds of antimicrobial peptides which have antimicrobial activity towards ...
Shurui Cai +8 more
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Evaluating performance, intestinal lesions, and immunity related genes in heritage and modern broiler breeds during a necrotic enteritis challenge [PDF]
Poultry Science: In this comparative study, the differential responses of heritage (ACRB; Athens Canadian Random Bred) and modern (Cobb) broilers to a necrotic enteritis (NE) challenge were evaluated.
Laney E. Froebel +4 more
doaj +2 more sources
Effects of Bacillus coagulans on growth performance and intestinal mucosal barrier functions of juvenile channel catfish (Ictalurus punctatus) [PDF]
Frontiers in ImmunologyTo investigate the effects of Bacillus coagulans on growth performance and intestinal mucosal barrier functions of juvenile channel catfish (Ictalurus punctatus), this study formulated two experimental diets: a control diet (CN group, without B ...
Huige Ren +9 more
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Effect of orally administered B. subtilis-cNK-2 on growth performance, immunity, gut health, and gut microbiome in chickens infected with Eimeria acervulina and its potential as an alternative to antibiotics [PDF]
Poultry Science: This study investigated the best oral delivery strategy (gavage or feed) for the B. subtilis expressing the chicken anti-microbial peptide cNK-2 (B.
Samiru S. Wickramasuriya +7 more
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