New Insight Into the Biological Activity of Salmo salar NK-Lysin Antimicrobial Peptides [PDF]
Frontiers in ImmunologyNK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like proteins family first isolated from a pig’s small intestine.
Natacha Santibáñez +2 more
exaly +8 more sources
Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis. [PDF]
PLoS ONE, 2018 Antimicrobial peptides (AMPs) are a diverse group of molecules which play an important role in the innate immune response. Bovine NK-lysins, a type of AMP, have been predominantly found in the granules of cytotoxic T-lymphocytes and NK-cells.
Rohana P Dassanayake +5 more
doaj +6 more sources
Characterization of transcription profile and structural properties of avian NK-lysin [PDF]
Poultry Science, 2020 This study aimed to determine the transcription profile of NK-lysin gene in native chickens. Moreover, it was targeted toward determining the primary, three-dimensional, and molecular dynamic structures of NK-lysin and granulysin peptides to understand ...
Maged M. Mahmoud, Haitham A. Yacoub
doaj +4 more sources
Bovine NK-lysin-derived peptides have bactericidal effects against Mycobacterium avium subspecies paratuberculosis [PDF]
Veterinary Research, 2021 Infection with Mycobacterium avium subspecies paratuberculosis (MAP) is complex, but little is known about the role that natural killer (NK) cells play.
Rohana P. Dassanayake +5 more
doaj +3 more sources
Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. [PDF]
PLoS ONE, 2017 Bovine NK-lysins, which are functionally and structurally similar to human granulysin and porcine NK-lysin, are predominantly found in the granules of cytotoxic T-lymphocytes and NK-cells.
Rohana P Dassanayake +4 more
doaj +3 more sources
Effect of Nk-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities [PDF]
Animal Biotechnology, 2023 NK-lysins from chicken, bovine and human are used as antiviral and antibacterial agents. Gram-negative and gram-positive microorganisms, including Streptococcus pyogenes, Streptococcus mutans, Escherichia coli, Pseudomonas aeruginosa, Klebsiella oxytoca,
Haitham A. Yacoub +5 more
doaj +4 more sources
Bovine NK-lysin peptides exert potent antimicrobial activity against multidrug-resistant Salmonella outbreak isolates [PDF]
Scientific Reports, 2021 Multidrug-resistant (MDR) Salmonella is a threat to public health. Non-antibiotic therapies could serve as important countermeasures to control MDR Salmonella outbreaks.
Rohana P. Dassanayake +7 more
doaj +3 more sources
Functional Characterization of Porcine NK-Lysin: A Novel Immunomodulator That Regulates Intestinal Inflammatory Response [PDF]
Molecules, 2021 Porcine NK-Lysine (PNKL) is a new antimicrobial peptide (AMP) identified in the small intestine. In this study, PNKL protein was obtained through heterologous expression in Escherichia coli and was estimated by SDS-PAGE at 33 kDa.
Qian Lin +11 more
doaj +2 more sources
Oral administration of chicken NK-lysin or recombinant chicken IL-7 improves vaccine efficacy of Eimeria tenella elongation factor-1α (EF-1α) against coccidiosis in commercial broiler chickens [PDF]
Poultry Science, 2023 : The synergistic effects of orally-delivered chicken NK-lysin peptide 2 (cNK-2) or recombinant chicken IL-7 (rchIL-7) on vaccination with recombinant Eimeria elongation factor-1α (rEF-1α) against Eimeria maxima (E.
Youngsub Lee +2 more
doaj +2 more sources
Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1α vaccination against Eimeria maxima infection in broiler chickens [PDF]
Poultry Science, 2022 : This study was conducted to develop a recombinant Eimeria elongation factor-1α (EF-1α)-vaccination strategy against Eimeria maxima (E. maxima) infection by co-administering with chicken IL-7 (chIL-7) or chicken NK-lysin peptide 2 (cNK-2) in commercial ...
Youngsub Lee +5 more
doaj +2 more sources