Results 11 to 20 of about 113,543 (162)

Expression of the Bovine NK-Lysin Gene Family and Activity against Respiratory Pathogens. [PDF]

PLoS ONE, 2016
Unlike the genomes of many mammals that have a single NK-lysin gene, the cattle genome contains a family of four genes, one of which is expressed preferentially in the lung.
Junfeng Chen, Chingyuan Yang, Polyana C Tizioto, Huan Huang, Mi O K Lee, Harold R Payne, Sara D Lawhon, Friedhelm Schroeder, Jeremy F Taylor, James E Womack   +9 more
doaj   +7 more sources

Porcine Recombinant NK-Lysin Inhibits the Growth and Metastasis of Murine Hepatocellular Carcinoma In Vivo [PDF]

Molecules
Porcine recombinant NK-lysin (prNK-lysin) has been shown to inhibit the proliferation and metastasis of hepatocellular carcinoma (HCC) cells in vitro. However, its effects on the proliferation and metastasis of HCC cells in vivo remain unclear.
Kuohai Fan, Zhiwei Feng, Dahai Zhao, Xiaozhong Zheng, Wei Yin, Na Sun, Panpan Sun, Hongquan Li   +7 more
doaj   +5 more sources

NKLP27: a teleost NK-lysin peptide that modulates immune response, induces degradation of bacterial DNA, and inhibits bacterial and viral infection. [PDF]

PLoS ONE, 2014
NK-lysin is an antimicrobial protein produced by cytotoxic T lymphocytes and natural killer cells. In this study, we examined the biological property of a peptide, NKLP27, derived from tongue sole (Cynoglossus semilaevis) NK-lysin.
Min Zhang, Mo-fei Li, Li Sun
doaj   +3 more sources

Nucleated Teleost Erythrocytes Play an Nk-Lysin- and Autophagy-Dependent Role in Antiviral Immunity [PDF]

Frontiers in Immunology, 2017
With the exception of mammals, vertebrate erythrocytes are nucleated. Nevertheless, these cells are usually considered as mere carriers of hemoglobin. In this work, however, we describe for the first time an unrecognized role of teleost red blood cells ...
Patricia Pereiro, Alejandro Romero, Patricia Díaz-Rosales, Amparo Estepa, Antonio Figueras, Beatriz Novoa   +5 more
doaj   +6 more sources

Mapping and genotypic analysis of the NK-lysin gene in chicken. [PDF]

Genet Sel Evol, 2014
Antimicrobial peptides (AMP) are important elements of the first line of defence against pathogens in animals. NK-lysin is a cationic AMP that plays a critical role in innate immunity. The chicken NK-lysin gene has been cloned and its antimicrobial and anticancer activity has been described but its location in the chicken genome remains unknown.
Lee MO, Yang E, Morisson M, Vignal A, Huang YZ, Cheng HH, Muir WM, Lamont SJ, Lillehoj HS, Lee SH, Womack JE.   +10 more
europepmc   +9 more sources

Bovine NK-lysin: Copy number variation and functional diversification. [PDF]

Proc Natl Acad Sci U S A, 2015
Significance The cattle genome contains expanded families of several genes involved in innate immunity. A single copy of the NK-lysin gene is annotated in the genomes of most mammals, including humans, but this study identified a family of NK-lysin
Chen J, Huddleston J, Buckley RM, Malig M, Lawhon SD, Skow LC, Lee MO, Eichler EE, Andersson L, Womack JE.   +9 more
europepmc   +8 more sources

Characterization and Functional Evaluation of NK-lysin from Clownfish (Amphiprion ocellaris)

Fishes, 2023
In previous studies, natural killer lysin (NK-lysin) emerged as a crucial antimicrobial peptide (AMP) discharged by NK cells and CTLs. The sequence of NK-lysin was cloned and discovered in some fishes, but its function remains unclear.
Dapeng Yu, Haohang Zhao, Yiming Wen, Tao Li, Hongli Xia, Zhiwen Wang, Zhen Gan, Liqun Xia, Jianlin Chen, Yishan Lu   +9 more
doaj   +2 more sources

Lipid membrane binding of NK‐lysin [PDF]

FEBS Letters, 1998
The membrane‐binding properties and pore‐forming potential of the tumor‐lysing and antibacterial polypeptide NK‐lysin were investigated. Fluorescence quenching experiments show a drastic change of accessibility to Trp58 in solution and in association with a lipid membrane.
Ruysschaert, Jean Marie, Goormaghtigh, Erik, Homblé, Fabrice, Andersson, M, Liepinsh, E, Otting, G   +5 more
openaire   +3 more sources

Identification of an anti-mycobacterial domain in NK-lysin and granulysin. [PDF]

Biochem J, 1999
NK-lysin and granulysin are homologous cationic anti-bacterial peptides produced by pig and human cytolytic lymphocytes, respectively. The solution structure of NK-lysin comprises five amphipathic α-helices. To investigate the properties of a helix-loop-helix region postulated to be a membrane-docking part of NK-lysin, we synthesized 22- and 29-residue
Andreu D, Carreño C, Linde C, Boman HG, Andersson M.   +4 more
europepmc   +5 more sources

Synthetic bovine NK-lysin-derived peptide (bNK2A) does not require intra-chain disulfide bonds for bactericidal activity. [PDF]

PLoS ONE, 2019
Bovine NK-lysins are cationic antimicrobial proteins found predominantly in the cytosolic granules of T lymphocytes and NK-cells. NK-lysin-derived peptides show antimicrobial activity against both Gram positive and Gram negative bacteria. Mature NK-lysin
Rohana P Dassanayake, Shollie M Falkenberg, Eric M Nicholson, Robert E Briggs, Fred M Tatum, Vijay K Sharma, Timothy A Reinhardt   +6 more
doaj   +2 more sources