Results 321 to 330 of about 653,368 (363)
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Cytokine & Growth Factor Reviews, 2015
The role of Natural Killer cells in host defense against infections as well as in tumour surveillance has been widely appreciated for a number of years. Upon recognition of "altered" cells, NK cells release the content of cytolytic granules, leading to the death of target cells.
PAOLINI, Rossella +3 more
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The role of Natural Killer cells in host defense against infections as well as in tumour surveillance has been widely appreciated for a number of years. Upon recognition of "altered" cells, NK cells release the content of cytolytic granules, leading to the death of target cells.
PAOLINI, Rossella +3 more
openaire +3 more sources
Immunology & Cell Biology, 1999
Natural killer (NK) cells are a cell of the innate immune system that play an important role in the early response to viral infections and tumours. Natural killer cells are cytolytic, and secrete cytokines that influence the developing antigen‐specific immune response.
H S, Warren, M J, Smyth
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Natural killer (NK) cells are a cell of the innate immune system that play an important role in the early response to viral infections and tumours. Natural killer cells are cytolytic, and secrete cytokines that influence the developing antigen‐specific immune response.
H S, Warren, M J, Smyth
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Transplant Immunology, 2002
The requirement for cytotoxic T lymphocytes during allograft rejection is controversial. We have demonstrated that CD8+ T cells are not essential for allograft rejection or for the induction of apoptosis in two experimental models of transplantation. To determine candidate cells types which may play a role in the events leading to graft rejection, the ...
Christine L, Hsieh +4 more
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The requirement for cytotoxic T lymphocytes during allograft rejection is controversial. We have demonstrated that CD8+ T cells are not essential for allograft rejection or for the induction of apoptosis in two experimental models of transplantation. To determine candidate cells types which may play a role in the events leading to graft rejection, the ...
Christine L, Hsieh +4 more
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Reproductive BioMedicine Online, 2008
Despite early reports that natural killer (NK) cells are non-specific or have non-major histocompatibility complex (MHC)- restricted killing, it is now clear that NK cells express a panoply of receptors with defined specificity for ligands expressed on their cellular targets.
Wayne M, Yokoyama, Joan K, Riley
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Despite early reports that natural killer (NK) cells are non-specific or have non-major histocompatibility complex (MHC)- restricted killing, it is now clear that NK cells express a panoply of receptors with defined specificity for ligands expressed on their cellular targets.
Wayne M, Yokoyama, Joan K, Riley
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Annual Review of Immunology, 1998
▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of co-stimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I.
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▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of co-stimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I.
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Blood, 2010
In this issue of Blood , Baessler and colleagues find that the engagement of CD137 on mouse and human NK cells had opposite effects in that CD137 functioned as an inhibitory receptor in human NK cells and as a stimulatory receptor in mice.[1][1] As NK cells emerge as potential therapeutic ...
Jacqueline, Marvel, Thierry, Walzer
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In this issue of Blood , Baessler and colleagues find that the engagement of CD137 on mouse and human NK cells had opposite effects in that CD137 functioned as an inhibitory receptor in human NK cells and as a stimulatory receptor in mice.[1][1] As NK cells emerge as potential therapeutic ...
Jacqueline, Marvel, Thierry, Walzer
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2018
NK-cell malignancies are rare aggressive diseases associated with poor clinical outcome. There is a significant geographic variation in their incidence. At least a part of the reason for that is the fact that Epstein-Barr virus plays an important role in pathogenesis, and importantly, the plasma viral titer reflects disease burden and response to ...
Dai, Chihara, Yasuhiro, Oki
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NK-cell malignancies are rare aggressive diseases associated with poor clinical outcome. There is a significant geographic variation in their incidence. At least a part of the reason for that is the fact that Epstein-Barr virus plays an important role in pathogenesis, and importantly, the plasma viral titer reflects disease burden and response to ...
Dai, Chihara, Yasuhiro, Oki
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NK and NK/T cells in human senescence
Vaccine, 2000Natural killer (NK) cells are cytotoxic cells that play a critical role in the innate immune response against infections and tumors. Recent studies on NK cell biology have demonstrated that besides their cytotoxic function, NK cells express cytokine and chemokine receptors and also that they secrete other immunoregulatory cytokines and chemokines ...
R, Solana, E, Mariani
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Current Pharmaceutical Design, 2002
NK cells have been associated with immune surveillance of tumor cells and defense mechanisms against various pathogens. However, by their capacity for immunoregulation NK cells may also play a role in determining the response to allergens. The novel possibility that NK cell activity may in part decide development of allergic airway inflammation and ...
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NK cells have been associated with immune surveillance of tumor cells and defense mechanisms against various pathogens. However, by their capacity for immunoregulation NK cells may also play a role in determining the response to allergens. The novel possibility that NK cell activity may in part decide development of allergic airway inflammation and ...
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International Journal of Hematology, 2002
Natural killer (NK) cells are lymphocytes with large granular lymphocyte morphology, CD3-CD56+ phenotype, non-MHC-restricted cytotoxicity, and germ-line configuration T-cell receptor genes. Two types of lymphomas originating from NK cells have been described; blastic NK-cell lymphoma, and nasal-type NK-cell lymphoma.
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Natural killer (NK) cells are lymphocytes with large granular lymphocyte morphology, CD3-CD56+ phenotype, non-MHC-restricted cytotoxicity, and germ-line configuration T-cell receptor genes. Two types of lymphomas originating from NK cells have been described; blastic NK-cell lymphoma, and nasal-type NK-cell lymphoma.
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