Results 131 to 140 of about 8,284,629 (305)

Phage detection by a bacterial NLR-related protein is mediated by DnaJ

Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of the human innate immune system. Mammalian nucleotide-binding and leucine-rich repeat containing proteins (NLRs) and bacterial NLR-related proteins use a central NACHT domain to link detection of infection with initiation ...
Amy N. Conte, Madison E. Ruchel, Samantha M. Ridgeway, Emily M. Kibby, Toni A. Nagy, Aaron T. Whiteley   +5 more
openaire   +2 more sources

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu, Tsu‐Hsiang Lu, Yi‐Chan Wu, Chia‐Wei Lin, Chia‐Wen Tsai, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae

Bioinformatics and Biology Insights
Nucleotide-binding domain leucine-rich repeat (NLR) proteins are a key component of the plant innate immune system. In plant genomes, NLRs exhibit considerable presence/absence variation and sequence diversity.
Moray Smith, John T. Jones, Ingo Hein
semanticscholar   +1 more source

Corrosion resistance of Zn-Co-Fe alloy coatings on high strength steel [PDF]

, 2008
The corrosion properties of electrodeposited zinc-cobalt-iron (Zn-Co-Fe) alloys (up to 40 wt.% Co and 1 wt.% Fe) on steel were studied by using various electrochemical techniques and compared with zinc (Zn) and cadmium (Cd) coatings in 3.5% NaCl solution.
Mol, J.M.C., Lodhi, Z.F., Terryn, H., Hovestad, A., Hoen-Velterop, L. 't, Lohdi, Z.F., Wit, J.H.W. de, Wit, J.H.W.de   +7 more
core  

Development of a Nomogram‐Based Clinical Estimation Model for Pathological Upstaging in Patients With Preoperative Ductal Carcinoma In Situ

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Preoperative diagnosis of ductal carcinoma in situ (DCIS) may be followed by pathological upstaging to invasive ductal carcinoma (IDC) upon surgical excision, a discrepancy that significantly impacts surgical planning and decisions regarding sentinel lymph node biopsy (SLNB).
Yu‐Hua Chen, Chung‐Liang Li, Ping‐Fu Yang, Hui‐Hua Hsiao, Fang‐Ming Chen, Sin‐Hua Moi   +5 more
wiley   +1 more source

A CNL protein forms an NLR pair with NRCX to modulate plant immunity

Stress Biology
Abstract Nucleotide-binding leucine-rich repeat (NLR) proteins assemble into genetically linked pairs to mediate effector-triggered immunity (ETI) in plants. Here, we characterize the paired NLRs NRCX and NARY (NRCX adjacent resistance gene Y) in Nicotiana benthamiana.
Xiaohua Dong, Xiaoyan Zhang, Xu Lu, Yufeng Yang, Chuyan Xia, Weiye Pan, Zhiyuan Yin, Yaning Zhao, Gan Ai, Daolong Dou   +9 more
openaire   +2 more sources

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Toward Predicting Pandemic Potential: A Comparative Analysis of Virus‐Host Interactions Between Diverse Influenza A Viruses and the Human Innate Immune System

PROTEOMICS, EarlyView.
ABSTRACT Zoonotic infections caused by influenza A viruses (IAVs) of animal origin are a major public health concern, as they may represent the initial step toward the emergence of a pandemic strain. The host range of IAVs is shaped by species‐specific virus‐host interactions, and several host barriers have been identified that restrict the adaptation ...
Antoine Gerodez, Melanie Dos Santos, Mikaël Attia, Killian De Geest, Ibrahim Hamid, Rodrigue Tesse, Ilham Fdillate, Marc Boschmans, Steven Van Borm, Mieke Steensels, Benedicte Lambrecht, Lionel Tafforeau, Caroline Demeret, Cyril Barbezange   +13 more
wiley   +1 more source

Filamentation activates bacterial NLR-like antiviral protein

Abstract Bacterial antiviral STANDs (Avs) are evolutionarily related to the nucleotide-binding leucine-rich repeat containing receptors (NLRs) widely distributed in immune systems across animals and plants. Ef Avs5, an Avs type 5 protein from Escherichia fergusonii
Jianting Zheng, Yiqun Wang, Yuqing Tian, Xu Yang, Feng Yu   +4 more
openaire   +1 more source