Results 151 to 160 of about 8,284,629 (305)

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li   +12 more
wiley   +1 more source

Lesion Diameter Versus Inflammatory Biomarkers and Clinical Severity in Predicting Treatment Selection in Idiopathic Granulomatous Mastitis

open access: yesWorld Journal of Surgery, EarlyView.
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory breast disease with no established predictor to guide medical versus surgical treatment. Neutrophil‐to‐lymphocyte ratio (NLR) and C‐reactive protein (CRP) have been proposed, but prior reports rarely adjusted for lesion morphology or other markers of disease severity.
Muhammet Fatih Keyif, Sabahattin Destek
wiley   +1 more source

A viral effector blocks the turnover of a plant NLR receptor to trigger a robust immune response

open access: yesThe EMBO Journal
Plant intracellular nucleotide-binding and leucine-rich repeat immune receptors (NLRs) play a key role in activating a strong pathogen defense response. Plant NLR proteins are tightly regulated and accumulate at very low levels in the absence of pathogen
Chunli Wang   +15 more
doaj   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

open access: yesInsect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn   +8 more
wiley   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

open access: yesAllergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri   +11 more
wiley   +1 more source

Advanced Lung Cancer Inflammation Index as a Prognostic Inflammation–Nutrition Marker in Appendiceal High‐Grade Pseudomyxoma Peritonei: A 10‐Year Single‐Center Study

open access: yesANZ Journal of Surgery, EarlyView.
Among 223 patients with appendiceal high‐grade pseudomyxoma peritonei, a high advanced lung cancer inflammation index (ALI) was independently associated with improved overall survival. A nomogram integrating ALI with clinicopathological and surgical factors showed good discrimination, calibration, and clinical utility for predicting 1‐, 2‐, and 3‐year ...
Yun Gao   +4 more
wiley   +1 more source

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