Results 141 to 150 of about 8,284,629 (305)

Synergistic effects and clinical utilization of radioimmunotherapy for brain metastases from driver mutation‐negative non‐small cell lung cancer

Precision Radiation Oncology, EarlyView.
This review summarizes how combining radiotherapy with immune checkpoint inhibitors overcomes the immunosuppressive brain microenvironment in non‐small cell lung cancer (NSCLC) brain metastases. The synergy enhances immune cell infiltration and systemic anti‐tumor activity, improving survival outcomes for patients.
Silai Yu, Jianjiao Ni, Hongru Chen, Nuan Weng, Xi Yang, Xiao Chu, Li Chu, Zhengfei Zhu   +7 more
wiley   +1 more source

Two complementary NLRs from wild emmer wheat confer powdery mildew resistance

Nature Communications
Powdery mildew is a devastating disease that affects wheat yield and quality globally. Here, we identify a powdery mildew resistance locus MlIW39 from wild emmer wheat through map-based cloning, mutagenesis, and stable genetic transformation. Unlike many
Zuhuan Yang, Nannan Liu, Xiaoming Xie, Wenxin Wei, Yuhan Bai, Junna Sun, Wei Pan, Jiatian Yang, Weidong Wang, Xiaodong Xie, Muhammad Saqlain, Houyang Kang, Baoyun Li, Zhaorong Hu, Jinying Gou, Weilong Guo, Susheng Song, Jun Ma, Tzion Fahima, Qixin Sun, Lina Qiu, Yinghui Li, Chaojie Xie   +22 more
doaj   +1 more source

Oligomerization-mediated autoinhibition and cofactor binding of a plant NLR

Nature
Nucleotide-binding leucine-rich repeat (NLR) proteins play a pivotal role in plant immunity by recognizing pathogen effectors1,2. Maintaining a balanced immune response is crucial, as excessive NLR expression can lead to unintended autoimmunity3,4 ...
Shoucai Ma, Chunpeng An, Aaron W. Lawson, Yu Cao, Yue Sun, E. Tan, Jin-Heng Pan, J. Jirschitzka, Florian Kümmel, N. Mukhi, Zhifu Han, Shan Feng, Bin Wu, P. Schulze-Lefert, Ji-Jie Chai   +14 more
semanticscholar   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Pan-NLRome of Spinacia facilitates the rapid discovery of downy mildew resistance genes

Frontiers in Plant Science
Plant disease resistance is typically conferred by nucleotide-binding site leucine-rich repeats (NLR) proteins; however, the diversity of NLR genes in spinach has remained largely unexplored. We identified 2,549 NLR genes across 19 Spinacia assemblies of
Hongbing She, Hongbing She, Huiyu Wang, Zhaosheng Xu, Helong Zhang, Zhiyuan Liu, Zhiyuan Liu   +6 more
doaj   +1 more source

Inflammatory Markers‐Based Surgical Pathological Complete Response Prediction After Neoadjuvant Immunotherapy Combined With Chemotherapy in Head and Neck Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the predictive value of blood routine parameters for surgical pathological complete response (PCR) following neoadjuvant immunotherapy combined with chemotherapy (NICC) in patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC).
Yu‐Dong Ning, Yi‐Xuan Song, Han Li, Yu‐Qin He, Shao‐Yan Liu   +4 more
wiley   +1 more source

Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang, Man‐Hou Chao, Xin Luo, Feng‐Wen Shan, Zi‐Xuan Hua, Ze‐Zhi Guo, Hua‐Mei Yan, He Zhang, Tong Wu, Min Zhou, Rui Zheng, Shuo Wu, Xue‐Kun Huang, Zhao‐Hui Shi, Ya‐Na Zhang, Ji Yang, Qin‐Tai Yang   +16 more
wiley   +1 more source

A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity

bioRxiv
NRCs are essential helper NLR (nucleotide-binding domain and leucine-rich repeat) proteins that execute the immune response triggered by disease resistance proteins, also known as sensor NLRs.
J. Madhuprakash, AmirAli Toghani, Mauricio P. Contreras, Andrés Posbeyikian, Jake Richardson, Jiorgos Kourelis, T. Bozkurt, Michael W. Webster, S. Kamoun   +8 more
semanticscholar   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Immune Clues to Sinus Blues: Linking Biomarkers to Radiologic Score of Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a prolonged inflammatory condition of the nasal and paranasal sinuses that significantly affects quality of life. This study examines the relationship between CRS severity (based on Lund‐Mackay [LM] scores), osteitis, and systemic inflammatory markers, including neutrophil‐to‐lymphocyte ratio (NLR ...
Lubna Khreesha, Amer Sawalha, Mohammad Darweesh, Qusai Elfadel, Mohammad Alzoubi, Saif Alhawadi, Faris Alsawair, Fares Habboub, Bashar Alsmady, Mohammad Aljarboa, Hashim Alhammouri   +10 more
wiley   +1 more source