Results 141 to 150 of about 122,087 (266)

Phage detection by a bacterial NLR-related protein is mediated by DnaJ

Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of the human innate immune system. Mammalian nucleotide-binding and leucine-rich repeat containing proteins (NLRs) and bacterial NLR-related proteins use a central NACHT domain to link detection of infection with initiation ...
Amy N. Conte, Madison E. Ruchel, Samantha M. Ridgeway, Emily M. Kibby, Toni A. Nagy, Aaron T. Whiteley   +5 more
openaire   +2 more sources

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source

Inflammatory Markers‐Based Surgical Pathological Complete Response Prediction After Neoadjuvant Immunotherapy Combined With Chemotherapy in Head and Neck Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the predictive value of blood routine parameters for surgical pathological complete response (PCR) following neoadjuvant immunotherapy combined with chemotherapy (NICC) in patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC).
Yu‐Dong Ning, Yi‐Xuan Song, Han Li, Yu‐Qin He, Shao‐Yan Liu   +4 more
wiley   +1 more source

Comparative analysis of machine learning based methods for the prediction of NLR protein

, 2022
In intestinal tissue repair and innate immunity, the nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins play a fundamental role. The NLR protein family is a recent addition to the members of innate immunity effector molecules.
Gandotra, Ekta, Kumar, Narendra, Nadia, Nadia   +2 more
core  

Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease

Plants
In rice, leucine-rich repeat nucleotide-binding site (NLR) proteins are pivotal immune receptors in combating Magnaporthe oryzae-triggered rice blast.
Dewei Yang, Niqing He, Fenghuang Huang, Jialin Chen, Minxiang Yu, Yidan Jin, Shaojun Lin, Shengping Li   +7 more
doaj   +1 more source

Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang, Man‐Hou Chao, Xin Luo, Feng‐Wen Shan, Zi‐Xuan Hua, Ze‐Zhi Guo, Hua‐Mei Yan, He Zhang, Tong Wu, Min Zhou, Rui Zheng, Shuo Wu, Xue‐Kun Huang, Zhao‐Hui Shi, Ya‐Na Zhang, Ji Yang, Qin‐Tai Yang   +16 more
wiley   +1 more source

Structure and evolutionary history of a large family of NLR proteins in the zebrafish

Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Laird, Gavin K., Zielinski, Julia, Marioni, John C., Söylemez, Onuralp, 1985-, Schiffer, Philipp H., Wiehe, Thomas, Leptin, Maria, Howe, Kerstin, Kondrashov, Fyodor A., 1979-   +8 more
core  

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Filamentation activates bacterial NLR-like antiviral protein

Abstract Bacterial antiviral STANDs (Avs) are evolutionarily related to the nucleotide-binding leucine-rich repeat containing receptors (NLRs) widely distributed in immune systems across animals and plants. Ef Avs5, an Avs type 5 protein from Escherichia fergusonii
Jianting Zheng, Yiqun Wang, Yuqing Tian, Xu Yang, Feng Yu   +4 more
openaire   +1 more source

A CNL protein forms an NLR pair with NRCX to modulate plant immunity

Stress Biology
Abstract Nucleotide-binding leucine-rich repeat (NLR) proteins assemble into genetically linked pairs to mediate effector-triggered immunity (ETI) in plants. Here, we characterize the paired NLRs NRCX and NARY (NRCX adjacent resistance gene Y) in Nicotiana benthamiana.
Xiaohua Dong, Xiaoyan Zhang, Xu Lu, Yufeng Yang, Chuyan Xia, Weiye Pan, Zhiyuan Yin, Yaning Zhao, Gan Ai, Daolong Dou   +9 more
openaire   +2 more sources