Results 181 to 190 of about 8,284,629 (305)

Multi‐omics analyses reveal host–microbe interactions in atopic dermatitis and psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Atopic dermatitis (AD) and psoriasis (PSO) are chronic inflammatory skin diseases with complex host–microbe interactions. This study analysed skin samples from patients and healthy individuals using integrated microbial and transcriptomic profiling. Both diseases showed disrupted fungal–bacterial interactions and alterations in host immune responses ...
Ying Yang, Peter Olah, Alexander Salava, Jonathan Barker, Antti Lauerma, Björn Andersson, Nanna Fyhrquist, Bernhard Homey, Harri Alenius   +8 more
wiley   +1 more source

Disabling a conserved module confers broad‐spectrum resistance

Journal of Integrative Plant Biology, EarlyView.
This commentary reviews the discovery by Yuan et al. of a conserved susceptibility module where fungal Gas2 stabilizes host SnRK1β1A to suppress nuclear immunity in rice. It discusses the mechanism for broad‐spectrum resistance via genome editing and considers the essential balance between enhanced defense and associated agronomic trade‐offs.
Zhen Zeng, Yachun Su, Hui Ling, Youxiong Que   +3 more
wiley   +1 more source

Experimental pressure wave research at NLR for high-speed rail tunnels [PDF]

, 1998
Demmenie, E.A., Klaver, E., Bruin, A.C. de   +2 more
core  

Activated CCG10‐NLR: Octameric resistosome driving sustained calcium influx

Journal of Integrative Plant Biology, EarlyView.
This commentary spotlights landmark work from Guo et al. resolving the structure of the octameric resistosome formed by the active CCG10‐nucleotide‐binding leucine‐rich repeat (NLR) immune receptor WAI3, which triggers sustained, multi‐phasic Ca2+ influx.
Huayue Sun, Xiaohuan Jin, Mengchen Hu, Daowen Wang, Zheng Qing Fu   +4 more
wiley   +1 more source

Some notable aircraft service failures investigated by the National Aerospace Laboratory NLR [PDF]

, 2009
Wanhill, R.J.H.
core  

RING E3 ligase SNIPER8 functions redundantly with three close homologs to regulate the turnover of transcriptional co‐repressor TPR1

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis E3 ligase SNIPER8 negatively regulates immunity by promoting ubiquitination and proteasomal degradation of the transcriptional corepressor TOPLESS‐RELATED1, limiting excessive immune responses, maintaining immune homeostasis, and balancing defense activation and normal plant growth.
Xueru Liu, Paul Kapos, Zhongshou Wu, Yujun Peng, Meixuezi Tong, Asana Khajavi, Yan Huang, Yuelin Zhang, Xin Li   +8 more
wiley   +1 more source

The phase 2 up-grade of the NLR high speed tunnel HST [PDF]

, 1997
Jaarsma, F., Elsenaar, A.
core  

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Evaluation of windshear hazard displays and go-around procedures using piloted simulations at NLR [PDF]

, 1999
Haverdings, H., Rouwhorst, W.F.J.A.
core  

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source