Results 201 to 210 of about 134,694 (275)

TREM‐1 Blockade Inhibits Inflammasome Activation and Pyroptosis: Novel Insights on the Role of TREM‐1 and Syk in Monosodium Urate Crystal‐Induced Inflammation

Immunology, Volume 178, Issue 2, Page 249-260, June 2026.
Schematic overview of the roles triggering receptor expressed on myeloid cells‐1 (TREM‐1) plays in monosodium urate (MSU) crystal‐induced inflammasome activation and IL‐1β secretion in gout arthritis. The present study provides novel data suggesting that blockade of TREM‐1 by LP17 attenuates MSU‐crystal‐induced inflammation through inhibition of ...
Yair Molad, Irina Lagovsky, Vitaly Kliminski   +2 more
wiley   +1 more source

Functional Dissection of a Wheat NLR Protein Reveals a Minimal Active Region and Key Regulatory Sites for Immune Signalling. [PDF]

Mol Plant Pathol
Zhu X, Jiang S, Zhao J, Peng F, Zhao R, Li X, Luo Y, Xiong Z, Li Q, Rolland F, Kang Z, Wang X, Liu Y, Huang L, Wang X.   +14 more
europepmc   +1 more source

Neutrophil‐to‐Lymphocyte Ratio as a Predictor of Cardiovascular Events in Psoriatic Disease: A Retrospective Cohort Study

ACR Open Rheumatology, Volume 8, Issue 5, May 2026.
Objective The aim of this study was to evaluate the neutrophil‐to‐lymphocyte ratio (NLR) as an independent predictor of major adverse cardiovascular events (MACEs) and all‐cause mortality in patients with psoriasis (PsO) or psoriatic arthritis (PsA). Methods We conducted a retrospective cohort study of 967 patients (825 with PsO and 142 with PsA) at a ...
Mauro Martini, Luciano Logiudice, Luis D. Mazzuoccolo, Nicolas Alvarado, Alfredo Vargas Caselles, Paola De La Torre, Valentina Torres Londono, Maria Laura Acosta Felquer, Javier Rosa, Enrique R. Soriano   +9 more
wiley   +1 more source

NOD-like receptor repertoire in the chromosome-level genome of the demosponge <i>Dysidea avara</i> (Schmidt, 1862). [PDF]

Front Immunol
Koutsouveli V, Torres-Oliva M, Marulanda-Gomez AM, Franke A, Fuß J, Schmitz RA, Hentschel U, Reusch TBH, Pita L.   +8 more
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Precision targeting: The dawn of artificially customized disease resistance. [PDF]

PLoS Pathog
Fan X, Lyu S, Fan W, Shu J, Cheng X.
europepmc   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1124-1133, May 2026.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

Functional characterization of HbRAR1 in <i>Hevea brasiliensis</i> reveals its role in the HSP90-SGT1-RAR1 complex during hypersensitive response. [PDF]

Front Plant Sci
Liu Q, Wang J, Yu F, Lu Y, Zhang Y, Wang M, Liang X.   +6 more
europepmc   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source

Interleukin-18: A Critical Culprit in Inflammatory Renal Disease. [PDF]

Kidney Int Rep
Sergi CM.
europepmc   +1 more source