Results 21 to 30 of about 82,639 (162)
NLR immune receptor–nanobody fusions confer plant disease resistance
Science, 2023 Plant pathogens cause recurrent epidemics, threatening crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen strains. Made-to-order synthetic plant immune receptors provide an opportunity to tailor resistance to pathogen ...
Jiorgos Kourelis +4 more
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NLR immune receptors: structure and function in plant disease resistance
Biochemical Society Transactions, 2023 Nucleotide-binding and leucine-rich repeat receptors (NLRs) are a diverse family of intracellular immune receptors that play crucial roles in recognizing and responding to pathogen invasion in plants. This review discusses the overall model of NLR activation and provides an in-depth analysis of the different NLR domains, including N-terminal ...
Alexander Förderer, Jiorgos Kourelis
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Plant NLR-triggered immunity: from receptor activation to downstream signaling [PDF]
Current Opinion in Immunology, 2020 Innate immune perception is the first line of inducible defense against invading pathogens. Plants lack specialized circulating immune cells. Therefore, diverse cell types are able to recognize and respond to pathogens. Surface-localized and intracellular plant innate immune receptors are capable of recognizing diverse pathogen components ...
Signe Lolle +2 more
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NLR immune receptor-nanobody fusions confer plant disease resistance [PDF]
, 2021 ABSTRACTPlant pathogens cause recurrent epidemics that threaten crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen races. Therefore, there is a need to develop made-to-order synthetic plant immune receptors with resistance
Jiorgos Kourelis +2 more
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NOD-like receptors (NLRs): bona fide intracellular microbial sensors [PDF]
Current Opinion in Immunology, 2008 The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) (nucleotide-binding domain leucine-rich repeat containing) family of proteins has been demonstrated to function as regulators of innate immune response against microbial pathogens.
Michael H, Shaw +3 more
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Current Opinion in Plant Biology, 2021 Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild relatives.
Sánchez-Martín, Javier, Keller, Beat
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Structural Insights into the Plant Immune Receptors PRRs and NLRs [PDF]
Plant Physiology, 2020 Les progrès récents réalisés dans l'analyse structurelle des PRR et des NLR des plantes montrent les progrès de la biologie structurelle cryo-EM.
Jizong Wang, Jijie Chai
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Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases [PDF]
International Journal of Molecular Sciences, 2021 The innate immune system plays a pivotal role in the first line of host defense against infections and is equipped with patterns recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Katarzyna Wicherska-Pawłowska +2 more
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PLoS ONE, 2020 Plant NLR immune receptors are multidomain proteins that can function as specialized sensor/helper pairs. Paired NLR immune receptors are generally thought to function via negative regulation, where one NLR represses the activity of the second and ...
Rafał Zdrzałek +4 more
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Frontiers in Cellular and Infection Microbiology, 2021 Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease in humans and in animals. In a mouse model, elimination of A. phagocytophilum required CD4+ T cells,
Beate J. Müller +7 more
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