Results 21 to 30 of about 98,851 (337)

Diverse NLR immune receptors activate defence via the RPW8‐NLR NRG1 [PDF]

New Phytologist, 2019
Summary Most land plant genomes carry genes that encode RPW8‐NLR Resistance (R) proteins. Angiosperms carry two RPW8‐NLR subclasses: ADR1 and NRG1. ADR1s act as ‘helper’ NLRs for multiple TIR‐ and CC‐NLR R proteins in Arabidopsis. In angiosperm families, NRG1 co‐occurs with TIR‐NLR Resistance (R) genes.
Castel, Baptiste, Ngou, Pok‐Man, Cevik, Volkan, Redkar, Amey, Kim, Dae‐Sung, Yang, Ying, Ding, Pingtao, Jones, Jonathan D. G.   +7 more
openaire   +4 more sources

Pathways to engineering plant intracellular NLR immune receptors

Current Opinion in Plant Biology, 2023
Factors including climate change and increased global exchange are set to escalate the prevalence of plant diseases, posing an unprecedented threat to global food security and making it more challenging to meet the demands of an ever-growing population.
Rafał Zdrzałek, Caroline Stone, Juan Carlos De la Concepcion, Mark J. Banfield, Adam R. Bentham   +4 more
openaire   +2 more sources

Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles [PDF]

Cell Host & Microbe, 2017
To establish infection, pathogens deploy effectors to modify or remove host proteins. Plant immune receptors with nucleotide-binding, leucine-rich repeat domains (NLRs) detect these modifications and trigger immunity. Plant NLRs thus guard host "guardees." A corollary is that autoimmunity may result from inappropriate NLR activation because mutations ...
Lolle, Signe, Greeff, Michael Christiaan, Petersen, Klaus, Roux, Milena Edna, Jensen, Michael Krogh, Bressendorff, Simon, Rodriguez Gomes, Eleazar José, Sømark, Kenneth, Mundy, John, Petersen, Morten   +9 more
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Plant TRAF Proteins Regulate NLR Immune Receptor Turnover [PDF]

Cell Host & Microbe, 2016
In animals, Tumor necrosis factor receptor-associated factor (TRAF) proteins are molecular adaptors that regulate innate and adaptive immunity, development, and abiotic stress responses. Although gene families encoding TRAF domain-containing proteins exhibit enriched diversity in higher plants, their biological roles are poorly defined. Here, we report
Huang, Shuai, Chen, Xuejin, Zhong, Xionghui, Li, Meng, Ao, Kevin, Huang, Jianhua, Li, Xin   +6 more
openaire   +3 more sources

Structural insights into plant NLR immune receptor function [PDF]

Proceedings of the National Academy of Sciences, 2016
Plants and animals use intracellular innate immune receptors known as nucleotide-binding oligomerization domain-like receptors (NLRs) to detect the presence of pathogens and activate defense. Although genetic studies have defined an increasing number of receptors and the pathogen triggers that activate them, the structural and mechanistic underpinnings
Farid El Kasmi, Marc T. Nishimura
openaire   +2 more sources

Pattern-recognition receptors are required for NLR-mediated plant immunity [PDF]

Nature, 2021
The plant immune system is fundamental for plant survival in natural ecosystems and for productivity in crop fields. Substantial evidence supports the prevailing notion that plants possess a two-tiered innate immune system, called pattern-triggered immunity (PTI) and effector-triggered immunity (ETI).
Minhang Yuan, Zeyu Jiang, Guozhi Bi, Kinya Nomura, Menghui Liu, Yiping Wang, Boying Cai, Jian-Min Zhou, Sheng Yang He, Xiu-Fang Xin   +9 more
openaire   +2 more sources

NOD‐like receptor (NLR) signaling beyond the inflammasome [PDF]

European Journal of Immunology, 2010
AbstractRecent years have witnessed a marked progress in our knowledge of NOD‐like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase‐1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome ...
Patrick J, Shaw, Mohamed, Lamkanfi, Thirumala-Devi, Kanneganti   +2 more
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Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. [PDF]

PLoS Pathogens, 2012
NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms.
Jonathan L Levinsohn, Zachary L Newman, Kristina A Hellmich, Rasem Fattah, Matthew A Getz, Shihui Liu, Inka Sastalla, Stephen H Leppla, Mahtab Moayeri   +8 more
doaj   +1 more source

Prognostic Value of Pretreatment Neutrophil-to-Lymphocyte Ratio in HER2-Positive Metastatic Breast Cancer

Current Oncology, 2022
This study aimed to examine the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and other clinicopathological features in HER2+ MBC patients who received first-line anti-HER2 therapy.
Bin Shao, Xiaoran Liu, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Ruyan Zhang, Ran Ran, Jiayang Zhang, Yaxin Liu, Huan Wang, Jing Wang   +12 more
doaj   +1 more source

NLR immune receptors: structure and function in plant disease resistance

Biochemical Society Transactions, 2023
Nucleotide-binding and leucine-rich repeat receptors (NLRs) are a diverse family of intracellular immune receptors that play crucial roles in recognizing and responding to pathogen invasion in plants. This review discusses the overall model of NLR activation and provides an in-depth analysis of the different NLR domains, including N-terminal ...
Alexander Förderer, Jiorgos Kourelis
openaire   +6 more sources