Results 31 to 40 of about 86,244 (257)

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Association Between Neutrophil-Lymphocyte Ratio and Oncotype Dx Recurrence Score in Early-Stage Hormonal Receptor-Positive, HER2-Negative, Node-Negative Breast Cancer

Cancer Management and Research, 2021
Bader Alshamsan,1,2 Aisha Alshibany,1 Mahmoud A Elshenawy,1,3 Ahmed Badran,1,4 Tusneem Elhassan,1 Dahish Ajarim,1 Adher Alsayed,1 Kausar Suleman,1 Taher Al-Tweigeri1 1Medical Oncology, Oncology Center, King Faisal Specialist Hospital & Research Centre ...
Alshamsan B, Alshibany A, Elshenawy MA, Badran A, Elhassan T, Ajarim D, Alsayed A, Suleman K, Al-Tweigeri T   +8 more
doaj  

Uncovering the repertoire of legume NLR immune receptors

, 2022
The legume family (Fabaceae) is the third-largest angiosperm family and is considered one of the most important crop families. Biotic stress constrains legume yield, and resistance breeding is currently considered the most sustainable management method to deal with pathogen pressure in the field.
Marques, Rita Maravilha, Santos, Carmen, Patto, Carlota Vaz, Kamoun, Sophien, Kourelis, Jiorgos   +4 more
openaire   +2 more sources

The NLR-Annotator Tool Enables Annotation of the Intracellular Immune Receptor Repertoire [PDF]

Plant Physiology, 2020
Disease resistance genes encoding nucleotide-binding and leucine-rich repeat (NLR) intracellular immune receptor proteins detect pathogens by the presence of pathogen effectors. Plant genomes typically contain hundreds of NLR-encoding genes. The availability of the hexaploid wheat (Triticum aestivum) cultivar Chinese Spring reference genome allows a ...
Steuernagel, Burkhard, Witek, Kamil, Krattinger, Simon G, Ramirez-Gonzalez, Ricardo H, Schoonbeek, Henk-jan, Yu, Guotai, Baggs, Erin, Witek, Agnieszka I, Yadav, Inderjit, Krasileva, Ksenia V, Jones, Jonathan D G, Uauy, Cristobal, Keller, Beat, Ridout, Christopher J, Wulff, Brande B H   +14 more
openaire   +5 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Effects of Primary Tumor Resection on Metastatic Breast Cancer Survival and the Predictive Power of Neutrophil: Lymphocyte Ratio on Prognosis

European Journal of Breast Health, 2021
Objective:The aim was to investigate the effect of primary tumor resection (PTR) on survival in metastatic breast cancer patients and to assess the power of the neutrophil-to-lymphocyte ratio (NLR) regarding the prediction of prognosis in this patient ...
Yaşar Çöpelci, Umut Rıza Gündüz, Bülent Dinç, Nurhan Haluk Belen, Şeyda Gündüz   +4 more
doaj   +1 more source

The allelic rice immune receptor Pikh confers extended resistance to strains of the blast fungus through a single polymorphism in the effector binding interface.

PLoS Pathogens, 2021
Arms race co-evolution drives rapid adaptive changes in pathogens and in the immune systems of their hosts. Plant intracellular NLR immune receptors detect effectors delivered by pathogens to promote susceptibility, activating an immune response that ...
Juan Carlos De la Concepcion, Josephine H R Maidment, Apinya Longya, Gui Xiao, Marina Franceschetti, Mark J Banfield   +5 more
doaj   +1 more source

Physiological and pathophysiological functions of NLRP6: pro- and anti-inflammatory roles

Communications Biology, 2022
This review discusses emerging roles for the NLR family pyrin domain containing 6 receptor (NLRP6) in intestinal homeostasis, inflammation, cancer, the nervous system and liver disease.
Diego Angosto-Bazarra, Cristina Molina-López, Pablo Pelegrín   +2 more
doaj   +1 more source

Protein-protein interactions in the RPS4/RRS1 immune receptor complex.

PLoS Pathogens, 2017
Plant NLR (Nucleotide-binding domain and Leucine-rich Repeat) immune receptor proteins are encoded by Resistance (R) genes and confer specific resistance to pathogen races that carry the corresponding recognized effectors.
Sung Un Huh, Volkan Cevik, Pingtao Ding, Zane Duxbury, Yan Ma, Laurence Tomlinson, Panagiotis F Sarris, Jonathan D G Jones   +7 more
doaj   +1 more source

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

Nature Communications, 2019
CC and TIR-domain type NLR receptors trigger plant immunity in response to pathogen effectors. Here, Bhandari et al. show that the EP-domain surface of EDS1 heterodimers signals downstream of both receptor types and ensures a rapid transcriptional ...
Deepak D. Bhandari, Dmitry Lapin, Barbara Kracher, Patrick von Born, Jaqueline Bautor, Karsten Niefind, Jane E. Parker   +6 more
doaj   +1 more source