Results 41 to 50 of about 86,244 (257)

Structures of plant resistosome reveal how NLR immune receptors are activated [PDF]

aBIOTECH, 2020
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins make up the largest immune receptor family in plants. Although many studies have put effort into revealing the working mechanism of NLRs, the activation details of plant NLRs still remain obscure.
Xuetao Shi, Suomeng Dong, Wende Liu
openaire   +2 more sources

Two unequally redundant "helper" immune receptor families mediate Arabidopsis thaliana intracellular "sensor" immune receptor functions.

PLoS Biology, 2020
Plant nucleotide-binding (NB) leucine-rich repeat (LRR) receptor (NLR) proteins function as intracellular immune receptors that perceive the presence of pathogen-derived virulence proteins (effectors) to induce immune responses.
Svenja C Saile, Pierre Jacob, Baptiste Castel, Lance M Jubic, Isai Salas-Gonzáles, Marcel Bäcker, Jonathan D G Jones, Jeffery L Dangl, Farid El Kasmi   +8 more
doaj   +1 more source

The correlation of the neutrophil–lymphocyte ratio to clinical and imaging parameters in patients with thyroid eye disease

Endocrine Connections, 2022
Thyroid eye disease (TED) is the major extrathyroidal manifesta tion of Graves’ disease (GD). Treatment choice is based on clinical activity and severi ty of TED, as evaluated with clinical activity score (CAS) and magnetic resonance (MR) imagi ng.
Xiaowen Zhang, Chen Han, Hongwei Wang, Xinghong Sun, Xin Dou, Xueying He, Di Wu, Shanmei Shen, Dalong Zhu, Xinlin Zhang, Yan Bi   +10 more
doaj   +1 more source

Baseline neutrophil-lymphocyte ratio (NLR) predicts toxicity and survival in HR+/HER-2 breast cancer patients treated with CDK4/6 inhibitors

Breast
The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been associated with prognosis in various malignancies. Its role in predicting toxicity and survival in patients with hormone receptor-positive, human epidermal growth
Omar Badran, Ali Darawshe, Sireen Sharif, Samih Yosef, Gil Bar-Sela   +4 more
doaj   +1 more source

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish

BMC Evolutionary Biology, 2008
Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa.
Winton James R, Purcell Maureen K, Laing Kerry J, Hansen John D   +3 more
doaj   +1 more source

Plant NLR-triggered immunity: from receptor activation to downstream signaling [PDF]

Current Opinion in Immunology, 2020
Innate immune perception is the first line of inducible defense against invading pathogens. Plants lack specialized circulating immune cells. Therefore, diverse cell types are able to recognize and respond to pathogens. Surface-localized and intracellular plant innate immune receptors are capable of recognizing diverse pathogen components ...
Signe Lolle, Danielle Stevens, Gitta Coaker   +2 more
openaire   +4 more sources

Low neutrophil-to-lymphocyte ratio and pan-immune-inflammation-value predict nodal pathologic complete response in 1274 breast cancer patients treated with neoadjuvant chemotherapy: a multicenter analysis

Therapeutic Advances in Medical Oncology, 2023
Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings. Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune ...
Maria Luisa Gasparri, Sara Albasini, Marta Truffi, Karin Favilla, Barbara Tagliaferri, Francesca Piccotti, Daniela Bossi, Giulia Armatura, Arianna Calcinotto, Corrado Chiappa, Francesca Combi, Annalisa Curcio, Angelica Della Valle, Guglielmo Ferrari, Secondo Folli, Matteo Ghilli, Chiara Listorti, Stefano Mancini, Peter Marinello, Simone Mele, Anna Pertusati, Manuela Roncella, Lorenzo Rossi, Francesca Rovera, Silvia Segattini, Adele Sgarella, Daniela Tognali, Fabio Corsi   +27 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells. [PDF]

PLoS ONE, 2012
Pattern recognition receptors (PRR), like Toll-like receptors (TLR) and NOD-like receptors (NLR), are involved in the detection of microbial infections and tissue damage by cells of the innate immune system. Recently, we and others have demonstrated that
Blandine C Mercier, Erwan Ventre, Marie-Laure Fogeron, Anne-Laure Debaud, Martine Tomkowiak, Jacqueline Marvel, Nathalie Bonnefoy   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source