Results 61 to 70 of about 1,342,871 (301)

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Simulation Framework Development for Helicopter Mission Analysis [PDF]

, 2010
Helicopter mission performance analysis has always been an important topic for the helicopter industry. This topic is now raising even more interest as aspects related to emissions and noise gain more importance for environmental and social impact ...
Mohseni, Martina, Pachidis, Vassilios, Vassilios Pachidis, Goulos, Ioannis, Stevens, J.M.G.F., Martina Mohseni, Roberto D’Ippolito, Ioannis Goulos, Jos Stevens, Mohseni, M., D’Ippolito, Roberto, Pachidis, V., Stevens, Jos, Goulos, I., d'Ippolito, R.   +14 more
core   +1 more source

Trions as Fundamental Species in Chemically Doped Polymer Semiconductors

Advanced Materials, EarlyView.
This work shows that exciton–charge carrier coupling in doped polymer semiconductors gives rise to multi‐particle states, including trions—quasiparticles consisting of two holes and one electron under p‐doping—and bound exciton‐hole pairs, as identified through spectroscopic and theoretical analysis.
Hongmo Li, Henry J. Kantrow, David A. Valverde‐Chávez, Meghan McNeil, Arianna Magni, Mohammad Balooch Qarai, Jude Kpare, Jaden Cramlet, Qiao He, Félix Thouin, Zhihao Feng, Yadong Zhang, Andrew Comstock, Stephen Barlow, Jason Azoulay, Seung Soon Jang, Renaud Demadrille, Martin Heeney, Seth Marder, Nicholas J. Hestand, Alberto Salleo, Frank C. Spano, Carlos Silva‐Acuña, Natalie Stingelin   +23 more
wiley   +1 more source

An E3 Ligase Affects the NLR Receptor Stability and Immunity to Powdery Mildew [PDF]

Plant Physiology, 2016
Following the detection of pathogen cognate effectors, plant Nod-like receptors (NLRs) trigger isolate-specific immunity that is generally associated with cell death. The regulation of NLR stability is important to ensure effective immunity. In barley (Hordeum vulgare), the allelic Mildew locus A (MLA) receptors mediate isolate-specific disease ...
Tao Wang, Cheng Chang, Cheng Gu, Sanyuan Tang, Qi Xie, Qian-Hua Shen   +5 more
openaire   +2 more sources

Prognostic value of neutrophil‐to‐lymphocyte ratio in gastric cancer patients treated with immune checkpoint inhibitors: A meta‐analysis

Kaohsiung Journal of Medical Sciences, 2023
The neutrophil‐to‐lymphocyte ratio (NLR) has been extensively studied in patients with gastric cancer (GC) treated with immune checkpoint inhibitors (ICIs), although the results are controversial.
Li‐Li Li, Li‐Sha Pan
doaj   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Effector Recognition and Activation of the Arabidopsis thaliana NLR Innate Immune Receptors [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2012
Plant immunity to coevolved pathogens relies on the perception of pathogenic effectors by nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins-sophisticated intracellular receptors that have both perception and signaling roles in activating defenses.
A D, Steinbrenner, S, Goritschnig, K V, Krasileva, K J, Schreiber, B J, Staskawicz   +4 more
openaire   +2 more sources

Plant NLR immunity activation and execution: a biochemical perspective

Open Biology
Plants deploy cell-surface and intracellular receptors to detect pathogen attack and trigger innate immune responses. Inside host cells, families of nucleotide-binding/leucine-rich repeat (NLR) proteins serve as pathogen sensors or downstream mediators ...
Federica Locci, Jane E. Parker
doaj   +1 more source

Genome-Wide Analysis of NLR Disease Resistance Genes in an Updated Reference Genome of Barley

Frontiers in Genetics, 2021
Barley is one of the top 10 crop plants in the world. During its whole lifespan, barley is frequently infected by various pathogens. In this study, we performed genome-wide analysis of the largest group of plant disease resistance (R) genes, the ...
Qian Li, Xing-Mei Jiang, Zhu-Qing Shao
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source