Results 71 to 80 of about 1,342,871 (301)

Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR)

International Journal of Biological Macromolecules, 2020
Innate immunity driven by pattern recognition receptor (PRR) protects the host from invading pathogens. Aquatic animals like fish where the adaptive immunity is poorly developed majorly rely on their innate immunity modulated by PRRs like toll-like receptors (TLR) and NOD-like receptors (NLR).
openaire   +3 more sources

Innate immune receptors for cross-presentation: The expanding role of NLRs

Molecular Immunology, 2019
A critical role of pattern recognition receptors (PRRs) is to influence adaptive immune responses by regulating antigen presentation. Engagement of PRRs in dendritic cells (DCs) increases MHC class I antigen presentation and CD8+ T-cell activation by cross-presented peptides but the molecular mechanisms underlying these effects are not completely ...
Corridoni, D, Simmons, A
openaire   +3 more sources

Absolute lymphocyte count and neutrophil-to-lymphocyte ratio as predictors of CDK 4/6 inhibitor efficacy in advanced breast cancer

Scientific Reports
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are the standard agents for treating patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer (ER + HER2 − ABC). However, markers predicting
Shogo Nakamoto, Tadahiko Shien, Takayuki Iwamoto, Shinichiro Kubo, Mari Yamamoto, Tetsumasa Yamashita, Chihiro Kuwahara, Masahiko Ikeda   +7 more
doaj   +1 more source

Impact of Neoadjuvant Chemotherapy on Hormone Receptor Status and Systemic Inflammatory Markers in Breast Cancer Patients: A Retrospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Breast Cancer (BC) remains the leading cause of cancer-related morbidity and mortality among women worldwide. Neoadjuvant Chemotherapy (NACT) is important in treating both locally advanced and early-stage BCs, as it helps make breast ...
K Hari Krishna, MS Supreetha, PN Sreeramalu   +2 more
doaj   +1 more source

Magnetic Water Cleaning of Estrogens via Tight yet Dynamic Binding to Nanoparticles

Advanced Science, EarlyView.
Micropollution is one of the big challenges humanity faces with estrogen hormones being emerging pollutants of concern. Here, a supramolecular design strategy is presented that generates a simple nano‐adsorbent material to magnetically remove low‐concentrated estrogens from water.
Lukas Müller, Philip Maier, Dustin Vivod, Wenke Müller, Nikolaj Lopatik, Theresa Maria Schichtl, Julia Fröhlich, Irene Kraus, Marten Huck, Wieland Corts, Clodomiro Cafolla, Lukas Ruhm, Henrik Gaß, Johannes Voß, Jiwon Byun, Linda Rockmann, Guido Grundmeier, Kislon Voïtchovsky, Hans‐Georg Steinrück, Erdmann Spiecker, Sevim Dalabasmaz, Monika Pischetsrieder, Eike Brunner, Ralf Schweins, Dirk Zahn, Marcus Halik   +25 more
wiley   +1 more source

Recent advances in plant NLR structure, function, localization and signaling

Frontiers in Immunology, 2013
Nucleotide-binding domain leucine-rich repeat (NLR) proteins play a central role in the innate immune systems of plants and vertebrates. In plants, NLR proteins function as intracellular receptors that detect pathogen effector proteins directly, or ...
Dong eQi, Roger W Innes
doaj   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

NOD-like receptors (NLRs): bona fide intracellular microbial sensors [PDF]

Current Opinion in Immunology, 2008
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) (nucleotide-binding domain leucine-rich repeat containing) family of proteins has been demonstrated to function as regulators of innate immune response against microbial pathogens.
Michael H, Shaw, Thornik, Reimer, Yun-Gi, Kim, Gabriel, Nuñez   +3 more
openaire   +2 more sources

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

The value of NLR in predicting the efficacy of preoperative nimotuzumab combined with neoadjuvant chemotherapy for local advanced oral squamous cell carcinoma [PDF]

口腔疾病防治
Objective To investigate the value of the peripheral blood neutrophil to lymphocyte ratio (NLR) before nimotuzumab combined with neoadjuvant chemotherapy in predicting the short-term efficacy of neoadjuvant therapy for advanced oral squamous cell ...
TIAN Liangliang, NAN Xinrong
doaj   +3 more sources