Results 21 to 30 of about 1,342,871 (301)
Structural insights into plant NLR immune receptor function [PDF]
Proceedings of the National Academy of Sciences, 2016 Plants and animals use intracellular innate immune receptors known as nucleotide-binding oligomerization domain-like receptors (NLRs) to detect the presence of pathogens and activate defense. Although genetic studies have defined an increasing number of receptors and the pathogen triggers that activate them, the structural and mechanistic underpinnings
Farid El Kasmi, Marc T. Nishimura
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Current Oncology, 2022 This study aimed to examine the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and other clinicopathological features in HER2+ MBC patients who received first-line anti-HER2 therapy.
Bin Shao +12 more
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A novel conserved mechanism for plant NLR protein pairs: the ‘integrated decoy’ hypothesis
Frontiers in Plant Science, 2014 Plant immunity is often triggered by the specific recognition of pathogen effectors by intracellular nucleotide-binding, leucine-rich repeat (NLR) receptors.
Stella ecesari +5 more
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Current Opinion in Plant Biology, 2021 Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance (R) genes and their corresponding avirulence (Avr) genes in wheat, barley, rye, and their wild relatives.
Sánchez-Martín, Javier, Keller, Beat
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PLoS Biology, 2021 In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can form receptor networks to confer hypersensitive cell death and innate immunity.
Lida Derevnina +15 more
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Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases [PDF]
International Journal of Molecular Sciences, 2021 The innate immune system plays a pivotal role in the first line of host defense against infections and is equipped with patterns recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Katarzyna Wicherska-Pawłowska +2 more
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PLoS ONE, 2020 Plant NLR immune receptors are multidomain proteins that can function as specialized sensor/helper pairs. Paired NLR immune receptors are generally thought to function via negative regulation, where one NLR represses the activity of the second and ...
Rafał Zdrzałek +5 more
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eLife, 2017 Plant immunity is tightly regulated to ensure proper defense against surrounding microbial pathogens without triggering autoimmunity, which negatively impacts plant growth and development.
Zhongshou Wu +5 more
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Frontiers in Cellular and Infection Microbiology, 2021 Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease in humans and in animals. In a mouse model, elimination of A. phagocytophilum required CD4+ T cells,
Beate J. Müller +7 more
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Development of a Nomogram-Based Clinical Estimation Model for Pathological Upstaging in Patients With Preoperative Ductal Carcinoma In Situ. [PDF]
Kaohsiung J Med SciABSTRACT Preoperative diagnosis of ductal carcinoma in situ (DCIS) may be followed by pathological upstaging to invasive ductal carcinoma (IDC) upon surgical excision, a discrepancy that significantly impacts surgical planning and decisions regarding sentinel lymph node biopsy (SLNB).
Chen YH +5 more
europepmc +2 more sources