Results 301 to 310 of about 98,851 (337)

Advances in Nod-like receptors (NLR) biology

Cytokine & Growth Factor Reviews, 2014
The innate immune system is composed of a wide repertoire of conserved pattern recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in response to endogenous or exogenous pathogenic insults. Among these, nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular sentinels of cytosolic ...
François, Barbé, Todd, Douglas, Maya, Saleh   +2 more
openaire   +2 more sources

A nucleocytoplasmic-localized E3 ligase affects the NLR receptor stability

Biochemical and Biophysical Research Communications, 2021
Ubiquitination is a pivotal post-translational modification that regulates turnover of nucleotide-binding site and leucine-rich repeat receptors (NLRs). As a RING-type E3 ligase, BOI (Botrytis susceptible1 interactor) has been reported to interact with different proteins, and function in the nucleus.
Jianzhong Huang, Xiaoqiu Wu, Zhiyong Gao
openaire   +2 more sources

NLR surveillance of pathogen interference with hormone receptors induces immunity

Nature, 2022
Phytohormone signalling pathways have an important role in defence against pathogens mediated by cell-surface pattern recognition receptors and intracellular nucleotide-binding leucine-rich repeat class immune receptors1,2 (NLR). Pathogens have evolved counter-defence strategies to manipulate phytohormone signalling pathways to dampen immunity and ...
Jing Chen, Yanxiao Zhao, Xuanjie Luo, Hao Hong, Tongqing Yang, Shen Huang, Chunli Wang, Hongyu Chen, Xin Qian, Mingfeng Feng, Zhengqiang Chen, Yongxin Dong, Zhenchuan Ma, Jia Li, Min Zhu, Sheng Yang He, Savithramma P. Dinesh-Kumar, Xiaorong Tao   +17 more
openaire   +2 more sources

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

Seminars in Immunology, 2009
Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are two major forms of innate immune sensors, which provide immediate responses against pathogenic invasion or tissue injury. Activation of these sensors induces the recruitment of innate immune cells such as macrophages and neutrophils, initiates tissue repair processes, and results in adaptive ...
Masayuki, Fukata, Arunan S, Vamadevan, Maria T, Abreu   +2 more
openaire   +2 more sources

Molecular actions of NLR immune receptors in plants and animals

Science China Life Sciences, 2020
NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis
Wang, J., Chai, J.
openaire   +3 more sources

The evolution of plant NLR immune receptors and downstream signal components

Current Opinion in Plant Biology, 2023
Along with the emergence of green plants on this planet one billion years ago, the nucleotide binding site leucine-rich repeat (NLR) gene family originated and diverged into at least three subclasses. Two of them, with either characterized N-terminal toll/interleukin-1 receptor (TIR) or coiled-coil (CC) domain, serve as major types of immune receptor ...
Yang Liu, Yan-Mei Zhang, Yao Tang, Jian-Qun Chen, Zhu-Qing Shao   +4 more
openaire   +2 more sources

Engineering NLR immune receptors for broad-spectrum disease resistance

Trends in Plant Science, 2013
Two recent reports by Maekawa et al. and Narusaka et al. demonstrated the transfer of a nucleotide-binding domain and leucine-rich repeat (NLR) family of immune receptors into evolutionarily diverged plants without causing adverse fitness consequences.
openaire   +2 more sources

Recent advances of NLR receptors in vegetable disease resistance

Plant Science
Plants mainly depend on both cell-surface and intracellular receptors to defend against various pathogens. The nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular receptors that recognize pathogen effectors. The first NLR was cloned thirty years ago. Genomic sequencing and biotechnologies accelerated NLR gene isolation.
Qing, Wen, Shaoyun, Wang, Xiaolan, Zhang, Zhaoyang, Zhou   +3 more
openaire   +2 more sources

Molecular studies on plant NLR immune receptors

2020
In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) receptors play crucial roles in the recognition of pathogen-derived molecules and the activation of defense. Sensor NLRs (sNLRs) are polymorphic with the ability to recognize relatively diverse pathogenic effectors.
openaire   +1 more source