Results 211 to 220 of about 131,202 (338)

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

687 Loss of the NOD2-Related Molecule NLRP3 Results in Broad Changes in the Innate Immune Response and Intestinal Microbiota Resulting in an Increased Susceptibility to Intestinal Inflammation

, 2010
Simon A. Hirota, Jeff Ng, Maitham A. Khajah, Yan Li, Victor L. Lam, Kevin P. Rioux, Jürg Tschopp, Donna‐Marie McCafferty, Daniel A. Muruve, Justin A. MacDonald, Paul L. Beck   +10 more
openalex   +1 more source

NOD2-NLRP3 Axis and Asthma. [PDF]

J Asthma Allergy
Cai X.
europepmc   +1 more source

Role of Macrophage TLR4 Expression in the Immunopathogenesis of Severe Aplastic Anemia

Journal of Clinical Laboratory Analysis, EarlyView.
This study found that the high expression of TLR4 in macrophages of SAA patients was positively correlated with the sepsis level, and inhibition of TLR4 expression could reduce the macrophage sepsis level and the killing effect of CD8+ T cells, thus alleviating the over‐activated cellular immune response in SAA patients.
Mengran Gao, Xiaorui Meng, Yi Cui, Ling Deng, Xinrui Zhang, Chunyan Liu, Rong Fu   +6 more
wiley   +1 more source

Traditional Chinese Medicine Properties and Microcalorimetry: BioScience Evaluation

Med Research, EarlyView.
ABSTRACT The properties theory of traditional Chinese medicine (TCM), characterized by cold, hot, warm, and cool four properties, is fundamental to its development, distinguishing it from natural, botanical, and chemical medicines. However, despite its significance, there is no unified theoretical definition, bioscientific characterization, or ...
Qiang Li, Hengrui Liu, Jiayan Jin, Yixin Zhang, Shuyi Li, Lin Wang, Shirong Zhao, Chutse Wu, Zhie Fang, Jide Jin   +9 more
wiley   +1 more source

Faculty Opinions recommendation of Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes.

, 2010
Steve Ward
openalex   +2 more sources

NLRP3 inflammasome: structure, mechanism, drug-induced organ toxicity, therapeutic strategies, and future perspectives. [PDF]

RSC Med Chem
Singh DD.
europepmc   +1 more source

Inflammatory osteolysis: A conspiracy against bone [PDF]

, 2017
Abu-Amer, Abu-Amer, Anton, Bardin, Beranger, Chen, Christo, Claro, Cobelli, Coll, Dapunt, Deborah V. Novack, Dewhirst, Gabriel Mbalaviele, Georg Schett, Gravallese, Harre, Josse, Jovanovic, Kollias, Lukens, Maitra, McCall, Mukai, Negishi-Koga, Osta, Ozen, Pasco, Robaszkiewicz, Rubbert-Roth, Sanchez, Scianaro, Sharma, Steven L. Teitelbaum, Van Hauwermeiren, Wang, Zaki   +36 more
core   +2 more sources

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, EarlyView.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

, 2010
Denis Gris, Zhengmao Ye, Heather A. Iocca, Haitao Wen, Robin R. Craven, Pavel Gris, Max T. Huang, Monika Schneider, Stephen D. Miller, Jenny P.‐Y. Ting   +9 more
openalex   +2 more sources