Results 321 to 330 of about 135,752 (336)

Salvianolic Acid B Alleviates LPS-Induced Spleen Injury by Remodeling Redox Status and Suppressing NLRP3 Inflammasome. [PDF]

Antioxidants (Basel)
Wang H, Dou X, Wang R, Jiang Y, Zhang J, Qiao X, Liu Y, Zhang H, Lai C, Chen Y, Yong Q.   +10 more
europepmc   +1 more source

Interactions between particulate matter and bacteria during cowshed PM_2.5-induced respiratory injury initiates GBP2/Caspase-11/NLRP3-mediated intracellular bacterial defense and pyroptosis. [PDF]

Front Vet Sci
Du X, Ma Z, Sun Y, Jia Y, Zhang X, Zhao C, Liang X, Yu X, Gao Y.   +8 more
europepmc   +1 more source

NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy: Pathogenic Mechanisms and Therapeutic Targets. [PDF]

J Inflamm Res
Chen Y, Chen R, Ji X, Zeng Z, Guan C.
europepmc   +1 more source

Correction to “Gut–X axis”

iMeta, EarlyView.
wiley   +1 more source

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NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages

International Immunopharmacology, 2021
INF39 is a nontoxic, irreversible, acrylate-based NLRP3 inhibitor and a further optimization of ethyl 2-((2-chlorophenyl) hydroxyl) methyl) acrylate (INF4E). However, the detail mechanism and the direct target of its anti-inflammatory activity is not clear. Here, we show that INF39 is a specific inhibitor for NLRP3 inflammasome activation.
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi   +4 more
openaire   +3 more sources

Vasculitis and the NLRP3 inflammasome

Current Opinion in Rheumatology, 2023
Purpose of review Vasculitis are a group of heterogeneous conditions characterized by chronic inflammation of blood vessels, leading to tissue destruction and organ failure. Vasculitis is an inflammatory process in which immune effector cells infiltrate blood vessels and surrounding tissues.
Kamel, Hamzaoui, Agnès, Hamzaoui
openaire   +2 more sources

LMP7 inhibits the activation of NLRP3 inflammasome through interaction with NLRP3

Biochemical and Biophysical Research Communications, 2020
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by coding pattern recognition receptors (PRRs). As a well-known inflammasome, NLRP3 plays an essential role in helping the host immune response and driving antiviral processes.
Jing Jin, Aixin Li, Wenbiao Wang, Jianguo Wu, Jianguo Wu   +4 more
openaire   +3 more sources

Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases

Science Immunology, 2021
Thiolutin, an inhibitor of the BRISC deubiquitinating enzyme complex, specifically and potently inhibits NLRP3 inflammasome activation.
Ya-Ting Li, Ya-Ting Li, Wang Yu, Wang Yu, Guang-Ming Ren, Xuan-Yi Zhang, Miao Yu, Gui-Fang Dou, Rong-Hua Yin, Wen Zhang, Wen Zhang, Chang-Yan Li, Yang Xiao, Ting Wang, Ting Wang, Hui Chen, Xiao-Chun Zhang, Ge Changhui, Xian Liu, Liu Kai, Shou-Song Tao, Shou-Song Tao, Jie Zhang, Jie Zhang, Xiao-Ming Yang, Xiao-Ming Yang, Jian Li, Wen-Bing Ma, Bo-Xue Tian, Yi-Qun Zhan   +29 more
openaire   +3 more sources

Assessment of NLRP3 Inflammasome Activation and NLRP3-NEK7 Complex Assembly

2023
The NLRP3 inflammasome is a critical component of innate immunity that activates caspase-1 to induce inflammation in response to a wide spectrum of endogenous and exogenous stimuli. NLRP3 inflammasome activation has been shown by assays for the cleavage of caspase-1 and gasdermin D, the maturation of IL-1β and IL-18, and ASC speck formation in innate ...
Nathan, Kelley, Yuan, He
openaire   +2 more sources