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Science Immunology, 2021
Thiolutin, an inhibitor of the BRISC deubiquitinating enzyme complex, specifically and potently inhibits NLRP3 inflammasome activation.
Ya-Ting Li +29 more
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Thiolutin, an inhibitor of the BRISC deubiquitinating enzyme complex, specifically and potently inhibits NLRP3 inflammasome activation.
Ya-Ting Li +29 more
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Assessment of NLRP3 Inflammasome Activation and NLRP3-NEK7 Complex Assembly
2023The NLRP3 inflammasome is a critical component of innate immunity that activates caspase-1 to induce inflammation in response to a wide spectrum of endogenous and exogenous stimuli. NLRP3 inflammasome activation has been shown by assays for the cleavage of caspase-1 and gasdermin D, the maturation of IL-1β and IL-18, and ASC speck formation in innate ...
Nathan, Kelley, Yuan, He
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IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene
Cytokine, 2020Inflammasome activation induces the maturation and secretion of interleukin (IL)-1β and -18, and is dependent on NF-κB signaling to induce the transcription of the inflammasome components, called the priming step. This study elucidated the role of IκBζ, an atypical IκBs (inhibitor of κB) and a coactivator of NF-κB target genes, on the activation of ...
Geun-Shik Lee +9 more
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NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
Science SignalingInflammasomes are multiprotein complexes that drive inflammation and contribute to protective immunity against pathogens and immune pathology in autoinflammatory diseases. Inflammasomes assemble when an inflammasome scaffold protein senses an activating signal and forms a signaling platform with the inflammasome adaptor protein ASC.
Jared R. Coombs +16 more
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USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3
Autophagy, 20213-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A1; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1β: interleukin 1 beta; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MARCHF7/MARCH7: membrane associated ...
Baoshan Cai +11 more
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NLRP3 at the interface of metabolism and inflammation
Immunological Reviews, 2015SummaryThe discovery of the NLRP3 (NLR family, pyrin domain containing 3) inflammasome provided an important molecular mechanism in the induction of the central pro‐inflammatory cytokine interleukin‐1β (IL‐1β), via activation of caspase‐1, which processes pro‐IL‐1β into its mature active form.
Moritz Haneklaus, Luke A. J. O'Neill
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NLRP3 inflammasome activation in inflammaging
Seminars in Immunology, 2018The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic
Latz, Eicke, Duewell, Peter
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