Results 331 to 336 of about 135,752 (336)

IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene

Cytokine, 2020
Inflammasome activation induces the maturation and secretion of interleukin (IL)-1β and -18, and is dependent on NF-κB signaling to induce the transcription of the inflammasome components, called the priming step. This study elucidated the role of IκBζ, an atypical IκBs (inhibitor of κB) and a coactivator of NF-κB target genes, on the activation of ...
Geun-Shik Lee, Jae-Hee Ahn, Jeongeun Kim, Hyun-Jeong Ko, Huijeong Ahn, Eui-Ju Hong, Beum-Soo An, Sangjung Yu, Eunsong Lee, Mi-Na Kweon   +9 more
openaire   +3 more sources

USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3

Autophagy, 2021
3-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A1; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1β: interleukin 1 beta; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MARCHF7/MARCH7: membrane associated ...
Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu, Chengjiang Gao   +11 more
openaire   +3 more sources

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

Science Signaling
Inflammasomes are multiprotein complexes that drive inflammation and contribute to protective immunity against pathogens and immune pathology in autoinflammatory diseases. Inflammasomes assemble when an inflammasome scaffold protein senses an activating signal and forms a signaling platform with the inflammasome adaptor protein ASC.
Coombs, Jared, Zamoshnikova, Alina, Holley, Caroline, Maddugoda, Madhavi, Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel Franz, Vitak, Nazarii, Ross, Connie, Mellacheruvu, Manasa, Coll, Rebecca, Heinz, Leonhard, Burgener, Sabrina, Emming, Stefan, Chamaillard, Mathias, Boucher, Dave, Schroder, Kate   +16 more
openaire   +2 more sources

NLRP3 at the interface of metabolism and inflammation

Immunological Reviews, 2015
SummaryThe discovery of the NLRP3 (NLR family, pyrin domain containing 3) inflammasome provided an important molecular mechanism in the induction of the central pro‐inflammatory cytokine interleukin‐1β (IL‐1β), via activation of caspase‐1, which processes pro‐IL‐1β into its mature active form.
Moritz Haneklaus, Luke A. J. O'Neill
openaire   +3 more sources

The Nlrp3 inflammasome admits defeat

Trends in Immunology, 2015
The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory ...
Christina J. Groß, Olaf Groß
openaire   +3 more sources

The NLRP3 Conundrum

Arthritis & Rheumatology, 2023
James T. Rosenbaum, Tejpal Gill, Tammy M. Martin   +2 more
openaire   +2 more sources