Results 141 to 150 of about 157,319 (379)
Biotechnology and Bioengineering, EarlyView.A novel strategy for nuclear gene delivery in microalgae using a cell‐penetrating peptide (CPP) and nuclear localization signal (NLS) is described. The authors developed a triple nanocomplex of CPP, plasmid DNA, and SV40 NLS to enhance nuclear delivery in Chlamydomonas reinhardtii.
Eun Jeong Sim +10 more
wiley +1 more source
Symmetry broken and unbroken solutions of nonlocal NLS equation in 2+1 dimensions
Results in Physics, 2020 In this paper, we study a general nonlinear Schrödinger (NLS) equation in 2+1 dimensions which under appropriate nonlocal symmetry reduction leads to reverse space nonlocal NLS equation. We apply Darboux transformation and construct multiple solutions of
H. Sarfraz, U. Saleem
doaj
Normalized ground states for the NLS equation with combined nonlinearities [PDF]
Journal of Differential Equations, 2018 Nicola Soave
semanticscholar +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies
Chemistry &Biodiversity, EarlyView.Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang +8 more
wiley +1 more source
Scattering for NLS with a potential on the line
Asymptotic Analysis, 2016 We show the $H^{1}$ scattering for a one dimensional nonlinear Schr dinger equation with a non-negative, repulsive potential $V$ such that $V,xV\in W^{1,1}$, and a mass-supercritical non-linearity. We follow the approach of concentration-compacity/rigidity first introduced by Kenig and Merle.
openaire +4 more sources
ChemBioChem, Accepted Article.Nucleophosmin 1(NPM1) is an abundant human protein endowed with many functions whose dysregulation leads to various cancers and mutations are relevant in Acute Myeloid Leukemia (AML). In the wild type form, pentameric NPM1 resides mainly in the nucleolus even if it shuttles toward the cytosol exerting its chaperon function, conversely in AML‐mutated ...
Daniele Florio +7 more
wiley +1 more source
A peptide derived from the N‐terminal region of HIV‐1 Vpr promotes nuclear import in permeabilized cells: elucidation of the NLS region of the Vpr [PDF]
, 1998 Orit Karni +4 more
openalex +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, EarlyView.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
Karyopherin α7 (KPNA7), a divergent member of the importin α family of nuclear import receptors
BMC Cell Biology, 2010 Background Classical nuclear localization signal (NLS) dependent nuclear import is carried out by a heterodimer of importin α and importin β. NLS cargo is recognized by importin α, which is bound by importin β.
Kelley Joshua B +4 more
doaj +1 more source