Results 241 to 250 of about 149,179 (263)

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

BioEssays, Volume 48, Issue 1, January 2026.
TDP‐43 hyperphosphorylation occurs in neurodegenerative diseases, however, it is not a driver of TDP‐43 aggregation, but enhances TDP‐43 solubility, suggesting that TDP‐43 hyperphosphorylation is protective. Toxicity may arise from a broader phosphorylation‐driven cellular pathway disruption.
Simone Mosna, Dorothee Dormann
wiley   +1 more source

Development and evaluation of soy lecithin-derived nanoliposomes as a plant-based alternative to egg-yolk extender for Ongole-grade bull semen cryopreservation. [PDF]

Vet World
Gunawan M, Karja NWK, Setiadi MA, Kaiin EM, Said S, Arifiantini RI, Iskandar H.   +6 more
europepmc   +1 more source

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
wiley   +1 more source

Spatiotemporal regulation of endoplasmic reticulum stress visualized by live imaging of bipA mRNA in Aspergillus oryzae. [PDF]

Sci Rep
Sathongdejwisit P, Morita Y, Katakura Y, Takegawa K, Berepiki A, Higuchi Y.   +5 more
europepmc   +1 more source

Advances and Applications of Spatial Proteomics: From Organellar Maps to Clinical Translation

ChemBioChem, Volume 27, Issue 1, January 2026.
Spatial proteomics provides high‐resolution maps of protein localization and trafficking by combining advanced mass spectrometry with complementary imaging and computational tools. Emerging low‐input and automated workflows are expanding its applicability to challenging clinical samples, supporting mechanistic disease research and biomarker discovery ...
Chiara Bernardini, Maike Däther, Franziska R. Traube   +2 more
wiley   +1 more source

Biometric analysis of Oncorhynchus mykiss (Walbaum, 1792) and Salmo trutta, Linnaeus, 1758 from the different habitat in Himachal Pradesh. [PDF]

Sci Rep
Kumari H, Mahajan D, Thakur K, Brar B, Sharma AK, Kumar S, Das BK, Kumar R.   +7 more
europepmc   +1 more source

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts

Cytoskeleton, Volume 83, Issue 1, Page 29-39, January 2026.
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena, Xiao Zhou, Lauren Slevin, Christopher Brownlee, Rebecca Heald   +4 more
wiley   +1 more source

TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation. [PDF]

Mol Med Rep
Guo P, Sun M, Zhang J, Yuan Q, Cui H, Huang J, Luo J, Zhu Q, Zhang B, Hu L.   +9 more
europepmc   +1 more source

A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

Anna Demarinis, Sara Esmaeili, Crystall M. D. Swarbrick, Simone Ranno, Silvia Pavan, Jade K. Forwood, Brian P. McSharry, Martin Pál, Enzo Di Iorio, Gualtiero Alvisi   +9 more
openalex   +1 more source

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Cytoskeleton, Volume 83, Issue 1, Page 40-52, January 2026.
ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley, Taylor Mahoney, Christian Pagán Medina, Parsa Zareiesfandabadi, Matthew B. Rapp, Mastawal Tirfe, Sharonda J. LeBlanc, Meredith D. Betterton, Mary Williard Elting   +8 more
wiley   +1 more source