Results 241 to 250 of about 157,319 (379)
Regulation of physiological and pathological condensates by molecular chaperones
The FEBS Journal, EarlyView.Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree +5 more
wiley +1 more source
The FEBS Journal, EarlyView.TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler +20 more
wiley +1 more source
Solitary Waves in a Madelung Fluid Description of Derivative NLS Equations [PDF]
, 2008 D. Grecu +4 more
openalex +1 more source
Versatile roles of disordered transcription factor effector domains in transcriptional regulation
The FEBS Journal, EarlyView.Disordered effector domains (EDs) of transcription factors (TFs) play versatile roles in transcriptional regulation. These include mediating protein–protein interactions with protein complexes like, facilitating condensate formation to enhance transcriptional efficiency, modulating DNA‐binding specificity through genome scanning, and serving as hubs ...
Rhea R. Datta +3 more
wiley +1 more source
Cas9-mediated gene-editing frequency in microalgae is doubled by harnessing the interaction between importin α and phytopathogenic NLSs. [PDF]
Proc Natl Acad Sci U S ALe TT +14 more
europepmc +1 more source
On the number of positive solutions of singularly perturbed 1D NLS
, 2006 Patricio A. Felmer +2 more
openalex +2 more sources
Unraveling the functional dynamics of Caenorhabditis elegans stress‐responsive omega class GST‐44
The FEBS Journal, EarlyView.Omega‐class glutathione S‐transferases (GSTs) are integral to redox regulation and cellular stress responses. This study characterized GST‐44 in Caenorhabditis elegans, revealing its predominant expression in the intestine and excretory H‐cell, with significant upregulation under various stress conditions.
Charlotte Sophia Kaiser +9 more
wiley +1 more source
Controllability of NLS in the vicinity of solitary wave solutions
, 2006 Horst Lange, Holger Teismann
openalex +2 more sources
ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma
The FEBS Journal, EarlyView.KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe +12 more
wiley +1 more source