Results 251 to 260 of about 157,319 (379)

Extreme multivalency and a composite short linear motif facilitate PCNA‐binding, localisation and abundance of p21 (CDKN1A)

open access: yesThe FEBS Journal, EarlyView.
Regions flanking the PCNA‐binding motif in p21 contribute to high‐affinity binding through complementary charges without specific contacts. These regions affect p21 abundance, but their exact Lys/Arg composition is unimportant for PCNA binding. Conversely, both context and Lys/Arg composition of the N‐terminal flanking region are crucial for p21 ...
Signe Simonsen   +8 more
wiley   +1 more source

Spin Transition of Iron in Deep‐Mantle Ferromagnesite

open access: yesGeophysical Monograph Series, Page 115-125., 2020

This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.

Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions

Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Jiachao Liu, Suyu Fu, Jung‐Fu Lin
wiley  

+1 more source

Correlating p53 immunostaining patterns with somatic TP53 mutation and functional properties of mutant p53 in triple‐negative breast cancer

open access: yesHistopathology, EarlyView.
This study introduces newly defined criteria for interpreting p53 IHC expression in triple‐negative breast cancer. These criteria could enable the prediction of TP53 mutation types and their functional implications, providing valuable insights for future clinical research and potentially improving stratification of treatment options for patients.
Meejeong Kim   +7 more
wiley   +1 more source

Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence. [PDF]

open access: yesActa Neuropathol Commun
Mitra J   +6 more
europepmc   +1 more source

Antiretroviral therapy use, self‐reported adherence, and viral suppression among women living with HIV in Canada

open access: yesHIV Medicine, EarlyView.
Abstract Background Traditionally, ≥95% adherence was recommended for viral suppression (VS). Newer antiretroviral therapy (ART) is now being increasingly prescribed and may be more forgiving of lower adherence. The lifelong nature of ART presents adherence challenges, particularly for women living with HIV. We aimed to describe ART use and examine the
Maysaloun Mokaddam   +125 more
wiley   +1 more source

Characterization of a Novel <i>GATA4</i> Missense Variant p.Gly303Trp in a Family with Septal Heart Defects and Pulmonary Stenosis. [PDF]

open access: yesInt J Mol Sci
Fabiani M   +9 more
europepmc   +1 more source

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