Inhibition of nm23-H1 gene expression in chronic myelogenous leukemia cells. [PDF]
Oncol Lett, 2013 For solid tumors of a malignant origin, the expression of the nm23-H1 gene is a positive prognostic factor. However, for chronic myeloid leukemia (CML), the prognostic role of nm23-H1 gene expression is unknown. The present study investigated the impact of nm23-H1 gene expression on the proliferation and migration of the CML K562 cell line to elucidate
Dai Z, Xiao W, Jin Y.
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Análise transcricional dos genes TIMP-1 e NM23-H1 na invasão celular em astrocitoma difuso e glioblastoma multiforme [PDF]
Arquivos de Neuro-Psiquiatria, 2006 PURPOSE: To evaluate using transcription analysis the presence and importance of two genes: NM23-H1 and TIMP-1 on control of tumor cell invasion in diffuse astrocytomas (WHO II) and glioblastoma multiforme (WHO IV). METHOD: Northern blot analysis of NM23-
Bruce, Jeffrey +4 more
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Mutation of the nm23-H1 gene has a non-dominant role in colorectal adenocarcinoma. [PDF]
Mol Clin Oncol, 2016 Nm23-H1 is a metastasis suppressor gene, which is has a reduced expression in patients with digestive system cancer. However, the mechanistic basis for the genetic instability remains unknown. To study the expression of the nm23-H1 gene in patients with colorectal cancer, polymerase chain reaction-single strand conformation polymorphism was used to ...
Jin Y, Dai Z.
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Role of the nm23-H1 gene in the metastasis of gastric cancer. [PDF]
J Korean Med Sci, 1997 The nm23 gene is now generally accepted as one of the suppressor genes for metastasis in many types of human cancer. To investigate the role of the nm23 gene in gastric cancer, we examined the expression of nm23-H1 mRNA, mutations, and loss of heterozygosity (LOH) of the nm23-H1 gene in gastric cancers.
Hwang BG +7 more
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[Comparative proteomics study on human high-metastatic large cell lung cancer cell lines before and after transfecting with nm23-H1 gene]. [PDF]
Zhongguo Fei Ai Za Zhi, 2010 Background and objective As a tumor metastasis suppressor gene, the functions of nm23-H1 gene are still unclear. The aim of this study is to better understand the mechanism of lung cancer metastasis and to find new biomarkers for early diagnosis and new ...
Gao L +6 more
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BglII and EcoRI polymorphism of the human nm23-H1 gene (NME1). [PDF]
Nucleic Acids Res, 1991 Yagüe J +7 more
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Down-regulation of thenm23.h1 gene inhibits cell proliferation [PDF]
International Journal of Cancer, 1997 nm23 gene expression is strictly related to the state of cell growth. The level of its expression parallels the fraction of thymidine-incorporating cells (S-phase cells) in neoplastic mammary tissues and in the synchronously cycling fraction of MCF 1OA cells.
CIPOLLINI G +7 more
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Negative Regulation of the Antimetastatic Gene Nm23-H1 by Thyroid Hormone Receptors* [PDF]
Endocrinology, 2000 Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The possible role of thyroid hormones in tumor metastasis has now been investigated by examining the effect of T3 on the expression of the Nm23-H1 gene.
K H, Lin, H Y, Shieh, H C, Hsu
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The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]
, 2020 International ...
Boissan, Mathieu +6 more
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Altered gene and protein expression by Nm23-H1 in metastasis suppression [PDF]
Molecular and Cellular Biochemistry, 2009 Metastasis suppressor genes (MSG) are characterized by their ability to inhibit the formation of metastasis, while not affecting the growth of the primary tumor in vivo. Nm23-H1, the first MSG to be characterized, has been shown to alter both gene and protein expression in cancer cells.
Jong Heun, Lee +3 more
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