Results 131 to 140 of about 2,849 (172)
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Tumor suppressor gene nm23-H1 in sporadic colon adenocarcinoma
European Journal of Cancer, 2001The discovery of genetic alterations in oncogenes and tumor-suppressor genes, which accompany tumor formation in a wide variety of human tumor types, has encouraged the search for genes that may promote or suppress tumor spread and metastasis. Nm23 gene was originally identified by differential hybridisation of K-1735 melanoma cell line clones of ...
Radošević, Senka +4 more
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Mutational Analysis of the NM23.H1 Gene in Human Breast Cancer
Cancer Genetics and Cytogenetics, 2000NM23.H1 is a protein connected with tumor progression. Loss of heterozygosity and reduced expression of the gene have been associated with poor prognosis and increased incidence of metastases in many epithelial tumors. The aim of this study was to detect the presence of NM23.H1 point mutations or small deletions in human breast carcinomas by using the ...
G, Cipollini +5 more
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Expression of nm23-H1 gene product in thyroid, ovary, and breast cancers
Cell Biophysics, 1995The nm23 gene product is one of several possible mediators of cancer invasion and metastasis. As the amounts of nm23-H1 mRNA and gene product are reduced in metastatic lymph nodes from patients with papillary carcinoma of the thyroid, we examined the expression of nm23 gene product in 115 thyroid cancers, 78 ovarian cancers, 63 breast cancers, and ...
T, Okubo +5 more
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nm23-H1 gene expression in ovarian tumors--a potential tumor marker.
Anticancer research, 1995Ovarian carcinomas that have a distinctive natural history with early dissemination are particularly problematic. The aim of this immunohistochemical study was to assess whether the nm23-H1 gene product, which in some tumors shows inverse association with metastatic potential, could serve as a prognostic marker for ovarian carcinomas.
Kapitanović, Sanja +8 more
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Expression of nm23-H1 Gene and Sialyl Lewis X Antigen in Breast Cancer
Oncology, 1998The nm23 gene has been proposed as a candidate tumor metastasis suppressor in some human cancers. Sialyl Lewis X (sLex) has been demonstrated to play an important role in the adhesion of human cancer cells to human vascular endothelium, inducing metastasis.
A, Yamaguchi +4 more
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p53 is a regulator of the metastasis suppressor gene Nm23‐H1
Molecular Carcinogenesis, 2003Abstractp53, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene Nm23‐H1, which encodes an 18‐kDa nucleoside diphosphate kinase, was previously identified in cells with low ...
Shen-Liang, Chen +5 more
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Downstream targets of Nm23‐H1: Gene expression profiling of CAL 27 cells using DNA microarray
Molecular Carcinogenesis, 2006AbstractThe human nm23‐H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside‐diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23 plays a key role in different cellular ...
Herak Bosnar, Maja +4 more
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Nm23-H1 gene silencing in CAL 27 cells
2008The metastatic process is a major characteristic of cancer invasion. There is a huge amount of evidence showing that metastatic potential is greatly influenced by expression of nm23-H1 gene in some cancer types. The product of nm23-H1 gene is a subunit of nucleosid-diphosphate kinase (NDPK), which also exhibits protein kinase and nuclease activity.
Herak Bosnar, Maja, Deželjin, Martina
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NM23-H1 and NM23-H2 gene expression in human renal tumors.
Anticancer research, 1998The two nm23 genes, nm23-H1 and nm23-H2, are implicated in the metastatic process and tumor progression in some human tumors. Until now no data exist about nm23 expression in the different types of human renal tumors. To investigate if the nm23 genes play a central role in the progression of renal tumors, we have examined nm23-H1 and nm23-H2 gene ...
B, Theisinger +4 more
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[Study on expression of nm23-H1 gene in laryngeal cancer tissues].
Zhonghua er bi yan hou ke za zhi, 1998The nm23 gene is a metastasis suppressor gene. There are now two known isotypes of human nm23, namely nm23-H1 and nm23-H2. Several investigators have reported that reduced expression of nm23-H1 is associated with metastasis or disease progression in some of the tumor cases.
Q, Wang, M, Guo, L, Sun
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