Results 11 to 20 of about 2,849 (172)

NSUN6 Maintains BMPER Stability in an m5C-Dependent Manner to Suppress Cell Proliferation and Migration in Hepatocellular Carcinoma. [PDF]

Biol Cell
In hepatocellular carcinoma (HCC), the methyltransferase NSUN6 catalyzes m⁵C modification of BMPER mRNA, enhancing its stability and elevating BMPER protein expression. This NSUN6‐BMPER axis suppresses HCC progression by inhibiting tumor cell proliferation/migration while correlating with improved patient prognosis, establishing RNA epigenetic ...
Liu C, Wu Y, Wu Y, Luo W, Hong Y, Jiang L, Wang S, Du D.   +7 more
europepmc   +2 more sources

The emerging landscape of eukaryotic polyphosphatases

FEBS Letters, Volume 597, Issue 11, Page 1447-1461, June 2023., 2023
Polyphosphatase enzymes in eukaryotic cells degrade polyphosphate (polyP) chains starting at the end of the chain (exopolyphosphatases), or by cleaving the chain internally to generate two smaller chains (endopolyphosphatases). While there are similarities in proposed polyphosphatases in yeast and mammalian systems, the yeast enzymes are better ...
Liam McCarthy, Michael Downey
wiley   +1 more source

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS‐STING Activation

Advanced Science, Volume 10, Issue 12, April 26, 2023., 2023
Persistent chromatin bridges trapped in the spindle midzone can be broken by actomyosin forces during cytokinesis. This study shows that ANKLE1 is a midbody‐tethered endonuclease that acts directly on DNA bridges trapped in the midbody to prevent the extensive formation of micronuclei and cytosolic DNA. Therefore, ANKLE1 prevents genome instability and
Huadong Jiang, Nannan Kong, Zeyuan Liu, Stephen C. West, Ying Wai Chan   +4 more
wiley   +1 more source

Based on Network Pharmacology‐Quercetin, a Component of Fuzheng Yiliu Decoction Suppressed Prostate Cancer by Regulating PI3K/AKT Pathway

Andrologia, Volume 2023, Issue 1, 2023., 2023
Background. Fuzheng Yiliu decoction (FZYLD) was a traditional prescription with an antitumor effect. We aimed to explore the antitumor effect of FZYLD and its active ingredient, quercetin, on prostate cancer (PCa). Methods. The effective components and potential targets of FZYLD were obtained from the TCMSP, Herb, and Batman databases. The relationship
Wei Fu, Lei Xu, Yingwen Chen, Xuyao Lin, Gaoli Hao, Chenxi Li, Hongying Li, Zezheng Zhang, Shuchao Chen, Xujun You, Qixin Li, Shuiqiao Yuan   +11 more
wiley   +1 more source

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments

PPAR Research, Volume 2022, Issue 1, 2022., 2022
Peroxisome proliferator‐activated receptors (PPARs) are members of the ligand‐dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular ...
Ayesheh Enayati, Mobina Ghojoghnejad, Basil D. Roufogalis, Seyed Adel Maollem, Amirhossein Sahebkar, John P. Vanden Heuvel   +5 more
wiley   +1 more source

Potential Functional Food Products and Molecular Mechanisms of Portulaca Oleracea L. on Anticancer Activity: A Review

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Portulaca oleracea Linn. (P. oleracea L.) has recently gained attention as a functional food due to the chemical composition of this plant regarding bioactive compounds. The special attention to the use of P. oleracea as an ingredient in functional food products is also due to the promotion of sustainable food.
Pâmela Gomes de Souza, Amauri Rosenthal, Ellen Mayra Menezes Ayres, Anderson Junger Teodoro, Alexandros Georgakilas   +4 more
wiley   +1 more source

Necdin: A purposive integrator of molecular interaction networks for mammalian neuron vitality

Genes to Cells, Volume 26, Issue 9, Page 641-683, September 2021., 2021
Necdin interacts with major regulatory proteins such as E2F1, p53, neurotrophin receptors (TrkA, p75NTR), Sirt1 and PGC‐1α, which serve as highly connected hubs of protein–protein interaction networks for mitosis, apoptosis, differentiation, neuroprotection and energy homeostasis. By integrating these networks, necdin promotes the vitality of mammalian
Kazuaki Yoshikawa
wiley   +1 more source

Activation of Antimetastatic Nm23-H1 Gene Expression by Estrogen and Its α-Receptor [PDF]

Endocrinology, 2002
Abstract Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene.
Kwang-Huei, Lin, Won-Jing, Wang, Yi-Hsin, Wu, Sheue-Yann, Cheng   +3 more
openaire   +3 more sources